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SGLT2 INHIBITOR DOSING



Drug Dosage form Typical dosage range Maximum Dose Food Generic/Price Other
Canagliflozin

(Invokana®)
Tablet
  • 100 mg
  • 300 mg
Type 2 diabetes
  • Starting: 100 mg once daily
  • Maintenance: 100 - 300 mg once daily
  • See precautions for dosing in kidney and liver disease
300 mg a day Take before first meal of the day NO/$$$$
  • Manufacturer recommends 300 mg dose with UGT inducers. See drug interactions for more details.
  • CrCl 45 - 59ml/min - dose should not exceed 100 mg a day
  • CrCl < 45ml/min - DO NOT USE
Drug Dosage form Typical dosage range Maximum Dose Food Generic/Price Other
Dapagliflozin

(Farxiga®)
Tablet
  • 5 mg
  • 10 mg
Type 2 diabetes
  • Starting: 5 mg once daily
  • Maintenance: 5 - 10 mg once daily
  • See precautions for dosing in kidney and liver disease

10 mg a day Take in morning with or without food NO/$$$$
  • DO NOT USE in patients with GFR < 60 ml/min. See precautions for details.
Drug Dosage form Typical dosage range Maximum Dose Food Generic/Price Other
Empagliflozin

(Jardiance®)
Tablet
  • 10 mg
  • 25 mg
Type 2 diabetes
  • Starting: 10 mg once daily
  • Maintenance: 10 - 25 mg once daily
  • See precautions for dosing in kidney and liver disease

25 mg a day Take in morning with or without food NO/$$$$
  • DO NOT USE in patients with GFR < 45 ml/min. See precautions for details.



  • COMBINATION PRODUCTS WITH METFORMIN

Drug Dosage form Generic/Price
Invokamet®

(canagliflozin + metformin)
Canagliflozin - Metformin
  • 50 mg - 500 mg
  • 50 mg - 1000 mg
  • 150 mg - 500 mg
  • 150 mg - 1000 mg
NO/$$$$
Drug Dosage form Generic/Price
Synjardy®

(empagliflozin + metformin)
Empagliflozin - Metformin
  • 5 mg - 500 mg
  • 5 mg - 1000 mg
  • 12.5 mg - 500 mg
  • 12.5 mg - 1000 mg
NO/$$$$
Drug Dosage form Generic/Price
Xigduo™ XR

(dapagliflozin + extended-release
metformin
)
Dapagliflozin - Metformin ER
  • 5 mg - 500 mg
  • 5 mg - 1000 mg
  • 10 mg - 500 mg
  • 10 mg - 1000 mg
NO/$$$$



  • COMBINATION PRODUCTS WITH DPP-4 INHIBITORS

Drug Dosage form Generic/Price
Glyxambi®

(empagliflozin + linagliptin)
Empagliflozin - Linagliptin
  • 10 mg - 5 mg
  • 25 mg - 5 mg
NO/$$$$



  • PRICING

    • $ = 0 - $50
    • $$ = $51 - $100
    • $$$ = $101 - $150
    • $$$$ = > $151

    • Pricing based on one month of therapy at typical doses
    • Pricing based on survey of GoodRX.com®, HEB®, and Costco®, [accessed 9/2014]
    • Pricing may vary by region and availability



  • References:
  • 1 - Manufacturer's Package Insert for each drug listed