SGLT2 INHIBITOR DOSING

PRICING INFO


Drug Dosage form Dosing Generic/Price Food / Other
Canagliflozin

(Invokana®)
Tablet
  • 100 mg
  • 300 mg
Type 2 diabetes
  • Starting: 100 mg once daily
  • Maintenance: 100 - 300 mg once daily
  • Max: 300 mg once daily
  • See precautions for dosing in kidney and liver disease
NO/$$$$ FOOD
  • Take before first meal of the day

OTHER
  • Manufacturer recommends 300 mg dose with UGT inducers. See drug interactions for more details.
  • CrCl 45 - 59 ml/min: dose should not exceed 100 mg a day
  • CrCl < 45 ml/min: DO NOT USE

Drug Dosage form Dosing Generic/Price Food / Other
Dapagliflozin

(Farxiga®)
Tablet
  • 5 mg
  • 10 mg
Type 2 diabetes
  • Starting: 5 mg once daily
  • Maintenance: 5 - 10 mg once daily
  • Max: 10 mg once daily
  • See precautions for dosing in kidney and liver disease
NO/$$$$ FOOD
  • Take in morning with or without food

OTHER
  • GFR < 60 ml/min: DO NOT USE. See precautions for details.

Drug Dosage form Dosing Generic/Price Food / Other
Empagliflozin

(Jardiance®)
Tablet
  • 10 mg
  • 25 mg
Type 2 diabetes
  • Starting: 10 mg once daily
  • Maintenance: 10 - 25 mg once daily
  • Max: 25 mg once daily
  • See precautions for dosing in kidney and liver disease
NO/$$$$ FOOD
  • Take in morning with or without food

OTHER
  • GFR < 45 ml/min: DO NOT USE. See precautions for details.

  • COMBINATION PRODUCTS WITH METFORMIN

Drug Dosage form Dosing Generic/Price Food / Other
Invokamet®

canagliflozin + metformin
Canagliflozin - Metformin
  • 50 mg - 500 mg
  • 50 mg - 1000 mg
  • 150 mg - 500 mg
  • 150 mg - 1000 mg
Type 2 diabetes
  • Starting: 50/500 mg twice daily
  • Maintenance: 50/500 - 150/1000 mg twice daily
  • Max: 150/1000 mg twice daily
NO/$$$$ FOOD
  • Take with food

OTHER

Drug Dosage form Dosing Generic/Price Food / Other
Invokamet® XR

canagliflozin + extended-release
metformin
Canagliflozin - Metformin ER
  • 50 mg - 500 mg
  • 50 mg - 1000 mg
  • 150 mg - 500 mg
  • 150 mg - 1000 mg
Type 2 diabetes
  • Starting: 50/500 mg once daily
  • Maintenance: 50/500 - 300/2000 mg once daily
  • Max: 300/2000 mg once daily
NO/$$$$ FOOD
  • Take with morning meal

OTHER
  • Swallow tablets whole. Do not crush, cut, or chew.


Drug Dosage form Dosing Generic/Price Food / Other
Synjardy®

empagliflozin + metformin
Empagliflozin - Metformin
  • 5 mg - 500 mg
  • 5 mg - 1000 mg
  • 12.5 mg - 500 mg
  • 12.5 mg - 1000 mg
Type 2 diabetes
  • Starting: 5/500 mg twice daily
  • Maintenance: 5/500 - 12.5/1000 mg twice daily
  • Max: 12.5/1000 mg twice daily
NO/$$$$ FOOD
  • Take with meals

OTHER


Drug Dosage form Dosing Generic/Price Food / Other
Synjardy® XR

empagliflozin + extended-release metformin
Empagliflozin - Metformin ER
  • 5 mg - 1000 mg
  • 10 mg - 1000 mg
  • 12.5 mg - 1000 mg
  • 25 mg - 1000 mg
Type 2 diabetes
  • Starting: 5/1000 mg once daily
  • Maintenance: 5/1000 - 25/2000 mg once daily
  • Max: 25/2000 mg once daily
NO/$$$$ FOOD
  • Take with morning meal

OTHER
  • Swallow tablets whole. Do not crush, cut, or chew.


Drug Dosage form Dosing Generic/Price Food / Other
Xigduo™ XR

dapagliflozin + extended-release metformin
Dapagliflozin - Metformin ER
  • 5 mg - 500 mg
  • 5 mg - 1000 mg
  • 10 mg - 500 mg
  • 10 mg - 1000 mg
Type 2 diabetes
  • Starting: 5/500 mg once daily
  • Maintenance: 5/500 - 10/2000 mg once daily
  • Max: 10/2000 mg once daily
NO/$$$$ FOOD
  • Take with food in the morning

OTHER
  • Swallow tablets whole. Do not crush, cut, or chew.
  • Inactive ingredients may be eliminated in the feces as a soft, hydrated mass that may resemble the original tablet

  • COMBINATION PRODUCTS WITH DPP-4 INHIBITORS

Drug Dosage form Dosing Generic/Price Food / Other
Glyxambi®

empagliflozin + linagliptin
Empagliflozin - Linagliptin
  • 10 mg - 5 mg
  • 25 mg - 5 mg
Type 2 diabetes
  • Starting: 10/5 mg once daily
  • Maintenance: 10/5 - 25/5 mg once daily
  • Max: 25/5 mg once daily
NO/$$$$ FOOD
  • May take without regard to food

OTHER