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SGLT2 INHIBITOR DOSING
  • NOTE: All dosing is for ADULT patients only
  • Dosing may vary for patients with liver problems, kidney problems, or other medical conditions



Drug Dosage form Typical dosage range Maximum Dose Food Generic/Price Other
Canagliflozin

(Invokana®)
Tablet
  • 100mg
  • 300mg
Type 2 diabetes
  • Starting: 100mg once daily
  • Maintenance: 100 - 300mg once daily
300mg a day Take before first meal of the day NO/$$$$
  • Manufacturer recommends 300mg dose with UGT inducers. See drug interactions for more details.
  • CrCl 45 - 59ml/min - dose should not exceed 100mg a day
  • CrCl < 45ml/min - DO NOT USE
  • See precautions for more
Drug Dosage form Typical dosage range Maximum Dose Food Generic/Price Other
Dapagliflozin

(Farxiga®)
Tablet
  • 5mg
  • 10mg
Type 2 diabetes
  • Starting: 5mg once daily
  • Maintenance: 5 - 10mg once daily

10mg a day Take in morning with or without food NO/$$$$
  • DO NOT USE in patients with GFR < 60 ml/min. See precautions for details.
Drug Dosage form Typical dosage range Maximum Dose Food Generic/Price Other
Empagliflozin

(Jardiance®)
Tablet
  • 10mg
  • 25mg
Type 2 diabetes
  • Starting: 10mg once daily
  • Maintenance: 10 - 25mg once daily

25mg a day Take in morning with or without food NO/$$$$
  • DO NOT USE in patients with GFR < 45 ml/min. See precautions for details.



  • COMBINATION PRODUCTS

Drug Dosage form Generic/Price
Invokamet®

(canagliflozin + metformin)
Canagliflozin - Metformin
  • 50mg - 500mg
  • 50mg - 1000mg
  • 150mg - 500mg
  • 150mg - 1000mg
NO/$$$$
Drug Dosage form Generic/Price
Xigduo™ XR

(dapagliflozin + extended-release
metformin
)
Canagliflozin - Metformin ER
  • 5mg - 500mg
  • 5mg - 1000mg
  • 10mg - 500mg
  • 10mg - 1000mg
NO/$$$$



  • PRICING

    • $ = 0 - $50
    • $$ = $51 - $100
    • $$$ = $101 - $150
    • $$$$ = > $151

    • Pricing based on one month of therapy at typical doses
    • Pricing based on survey of GoodRX.com®, HEB®, and Costco®, [accessed 9/2014]
    • Pricing may vary by region and availability



  • References:
  • 1 - Manufacturer's Package Insert for each drug listed