ACE INHIBITOR DOSING









Benazepril (Lotensin®)

Dosage forms

Tablet
  • 5 mg
  • 10 mg
  • 20 mg
  • 40 mg

Dosing

Hypertension (adults)
  • Starting: 10 mg once daily
  • Maintenance: 20 - 40 mg/day
  • Max: 80 mg/day
  • Consider starting dose of 5 mg if adding to a diuretic
  • May give in one or two divided doses
  • May take without regard to food
Hypertension (children ≥ 6 years old)
  • Dosing: 0.2 mg/kg once daily
  • Max: 0.6 mg/kg (max 40 mg) once daily
  • See Lotensin PI [sec 2.3] for instructions on compounding a 2 mg/ml suspension
  • May take without regard to food
Kidney disease (adults)
  • CrCl < 30 ml/min: recommended starting dose is 5 mg a day. Maximum dose is 40 mg a day.
Liver disease
  • No dose adjustment necessary

Generic / Price

- YES/$

Captopril (Capoten®)

Dosage forms

Tablet
  • 12.5 mg
  • 25 mg
  • 50 mg
  • 100 mg

Dosing

Hypertension (adults)
  • Starting: 25 mg two to three times a day
  • Maintenance: 25 - 150 mg two to three times a day
  • Max: 450 mg/day
  • Increase dose at 1 - 2 week intervals
  • Take 1 hour before meals. Food decreases absorption.
Hypertension (infants)
  • Starting: 0.05 mg/kg/dose
  • Max: 6 mg/kg/day
  • May given once daily to 4 times a day
  • AAP recommended dosing [2]
  • Take 1 hour before meals. Food decreases absorption.
Hypertension (children)
  • Starting: 0.5 mg/kg/dose
  • Max: 6 mg/kg/day
  • Give in three divided doses
  • AAP recommended dosing [2]
  • Take 1 hour before meals. Food decreases absorption.
Heart failure (adults)
  • Starting: 25 mg three times a day
  • Maintenance dose: 50 - 100 mg three times a day
  • Increase dose at 2 week intervals
  • Take 1 hour before meals. Food decreases absorption.
Diabetic nephropathy (adults)
  • Maintenance dose: 25 mg three times a day
  • Take 1 hour before meals. Food decreases absorption.
Kidney disease
  • For patients with significant kidney disease, start at lowest dose and titrate slowly
Liver disease
  • Manufacturer makes no recommendation

Generic / Price

- YES/$-$$

Enalapril | Vasotec® | Epaned®

Dosage forms

Tablet
  • 2.5 mg
  • 5 mg
  • 10 mg
  • 20 mg
Solution (Epaned®)
  • 1 mg/ml
  • Comes in 150 ml bottle

Dosing

Hypertension (adults)
  • Starting: 5 mg once daily
  • Maintenance: 10 - 40 mg/day
  • Max: 40 mg/day
  • Consider starting dose of 2.5 mg if adding to a diuretic
  • May be given in one or two divided doses
  • May take without regard to food
Hypertension (children ≥ 1 month)
  • Starting: 0.08 mg/kg (max 5 mg) once daily
  • Max: 0.60 mg/kg/day (max 40 mg)
  • May give once daily or in two divided doses
  • AAP recommended dosing [2]
  • See Vasotec PI for instructions on compounding a 1 mg/ml suspension
  • May take without regard to food
Heart failure (adults)
  • Starting: 2.5 mg twice a day
  • Maintenance: 2.5 - 20 mg twice a day
  • Max: 40 mg/day
  • Titrate over a period of a few days or weeks
  • May take without regard to food
Asymptomatic left ventricular dysfunction (adults)
  • Starting: 2.5 mg twice a day
  • Target: 10 mg twice a day
  • Titrate as tolerated
  • May take without regard to food
Kidney disease
  • CrCl ≤ 30 ml/min: recommended starting dose is 2.5 mg a day
Liver disease
  • Manufacturer makes no recommendation

Generic / Price

  • Tablet - YES/$
  • Solution (Epaned®) - YES/$$$$

Fosinopril (Monopril®)

Dosage forms

Tablet
  • 10 mg
  • 20 mg
  • 40 mg

Dosing

Hypertension (adults)
  • Starting: 10 mg once daily
  • Maintenance: 20 - 40 mg/day
  • Max: 80 mg/day
  • May be given in one or two divided doses
  • May take without regard to food
Hypertension (children ≥ 6 years old)
  • Starting: 0.1 mg/kg (max 5 mg) once daily
  • Max: 40 mg/day
  • AAP recommended dosing [2]
  • May take without regard to food
Hypertension (children ≥ 50 kg)
  • Starting: 5 mg/day
  • Max: 40 mg/day
  • AAP recommended dosing [2]
  • May take without regard to food
Heart failure (adults)
  • Starting dose: 10 mg once daily
  • Maintenance: 20 - 40 mg once daily
  • Max: 40 mg once daily
  • May take without regard to food
Kidney disease
  • No dose adjustment necessary for any degree of kidney disease
Liver disease
  • Drug clearance is decreased in patients with cirrhosis. Use caution.

Generic / Price

- YES/$

Lisinopril | Zestril® | Prinivil® | Qbrelis®

Dosage forms

Tablet
  • 2.5 mg
  • 5 mg
  • 10 mg
  • 20 mg
  • 30 mg
  • 40 mg
Solution (Qbrelis®)
  • 1 mg/ml
  • Comes in 150 ml bottle

Dosing

Hypertension (adults)
  • Starting: 10 mg once daily
  • Maintenance: 20 - 40 mg once daily
  • Max: 40 mg once daily
  • Lower starting doses may be appropriate in patients taking diuretics
  • May take without regard to food
Hypertension (children ≥ 6 years old)
  • Starting: 0.07 mg/kg (max 5 mg) once daily
  • Max: 0.61 mg/kg (max 40 mg) once daily
  • See Prinivil PI sec 2.5 for instructions on compounding a 1 mg/ml suspension
  • May take without regard to food
Heart failure (adults)
  • Starting: 5 mg once daily
  • Maintenance: 5 - 40 mg once daily
  • Max: 40 mg once daily
  • May take without regard to food
Kidney disease
  • CrCl 10 - 30 ml/min: give half the recommended starting dose
  • CrCl < 10 ml/min: starting dose is 2.5 mg a day
Liver disease
  • Manufacturer makes no recommendation

Generic / Price

  • Tablet - YES/$
  • Solution (Qbrelis®) - NO/$$$$

Moexipril (Univasc®)

Dosage forms

Tablet
  • 7.5 mg
  • 15 mg

Dosing

Hypertension (adults)
  • Starting: 7.5 mg once daily
  • Maintenance: 7.5 - 30 mg/day
  • Max: 60 mg/day
  • Lower starting dose may be appropriate in patients taking diuretics
  • May give in one or two divided doses
  • Take one hour before meals. Food decreases absorption.
Kidney disease
  • CrCl ≤ 40 ml/min: starting dose is 3.75 mg a day, and maximum dose is 15 mg a day
Liver disease
  • Drug clearance is decreased in patients with cirrhosis. Use caution.

Generic / Price

- YES/$

Perindopril (Aceon®)

Dosage forms

Tablet
  • 2 mg
  • 4 mg
  • 8 mg

Dosing

Hypertension (adults)
  • Starting: 4 mg once daily
  • Maintenance: 4 - 8 mg/day
  • Max: 16 mg/day
  • Lower starting doses may be appropriate in the elderly and in patients taking diuretics
  • May give in one or two divided doses
  • May take without regard to food
Stable coronary artery disease (adults)
  • Starting: 4 mg once daily for 2 weeks
  • Maintenance: 8 mg once daily
  • Elderly patients should be started at 2 mg once daily
  • May take without regard to food
Kidney disease
  • CrCl < 30 ml/min: not recommended
  • For lesser degrees of renal impairment, starting dose should be 2 mg and dose should not exceed 8 mg
Liver disease
  • In patients with impaired liver function, plasma concentrations of perindoprilat (active metabolite) were about 50% higher than those observed in healthy subjects. Manufacturer makes no dosage recommendation.

Generic / Price

- YES/$

Quinapril (Accupril®)

Dosage forms

Tablet
  • 5 mg
  • 10 mg
  • 20 mg
  • 40 mg

Dosing

Hypertension (adults)
  • Starting: 10 - 20 mg once daily
  • Maintenance: 20 - 80 mg/day
  • Max: 80 mg/day
  • Lower starting dose may be appropriate in patients taking diuretics
  • May be given in one or two divided doses
  • May take without regard to food
Hypertension (pediatric - age not specified by AAP)
  • Starting: 5 mg/day
  • Max: 80 mg/day
  • AAP recommended dosing [2]
  • May take without regard to food
Heart failure (adults)
  • Starting: 5 mg twice a day
  • Maintenance: 10 - 20 mg twice a day
  • Increase dose at 1 week intervals
  • May take without regard to food
Kidney disease (adults)
  • CrCl 30 - 60 ml/min: starting dose is 5 mg a day
  • CrCl 10 - 30 ml/min: starting dose is 2.5 mg a day
  • CrCl < 10 ml/min: no data available to make recommendation
Liver disease
  • Manufacturer makes no recommendation

Generic / Price

- YES/$

Ramipril (Altace®)

Dosage forms

Tablet and capsule
  • 1.25 mg
  • 2.5 mg
  • 5 mg
  • 10 mg

Dosing

Hypertension (adults)
  • Starting: 2.5 mg once daily
  • Maintenance: 2.5 - 20 mg/day
  • Max: 20 mg/day
  • May give in one or two divided doses
  • May take without regard to food
Hypertension (pediatric - age not specified by AAP)
  • Starting: 1.6 mg/m2/day
  • Max: 6 mg/m2/day
  • AAP recommended dosing [2]
  • May take without regard to food
Heart failure (adults)
  • Starting: 2.5 mg twice a day
  • Target: 5 mg twice a day
  • Increase dose at 3 weeks intervals
  • May take without regard to food
Kidney disease (adults)
  • CrCl < 40 ml/min: starting dose is 1.25 mg a day. Maximum dose is 5 mg a day.
Liver disease
  • Drug clearance is decreased in patients with cirrhosis. Use caution.

Generic / Price

- YES/$

Trandolapril (Mavik®)

Dosage forms

Tablet
  • 1 mg
  • 2 mg
  • 4 mg

Dosing

Hypertension (adults)
  • Starting (nonblack): 1 mg once daily
  • Starting (black): 2 mg once daily
  • Maintenance: 2 - 4 mg/day
  • Max: 8 mg/day
  • Lower starting dose may be appropriate in patients taking diuretics
  • May be given in one or two divided doses
  • May take without regard to food
Heart failure (adults)
  • Starting: 1 mg once daily
  • Target: 4 mg once daily
  • May take without regard to food
Kidney disease
  • CrCl < 30 ml/min: starting dose is 0.5 mg a day
Liver disease
  • Drug clearance is decreased in patients with liver disease
  • Starting dose in patients with cirrhosis is 0.5 mg a day

Generic / Price

- YES/$



Accuretic® | Quinaretic® (quinapril + HCTZ)

Dosage forms

Tablet
  • Quinapril - HCTZ
    • 10 mg - 12.5 mg
    • 20 mg - 12.5 mg
    • 20 mg - 25 mg

Dosing

Hypertension
  • Dosing: 10/12.5 mg - 40/25 mg once daily
  • Max: 40/25 mg once daily
  • Increase dose at intervals of 2 - 3 weeks
  • May take without regard to food

Generic / Price

- YES/$

Capozide® (captopril + HCTZ)

Dosage forms

Tablet
  • Captopril - HCTZ
    • 25 mg - 15 mg
    • 25 mg - 25 mg
    • 50 mg - 15 mg
    • 50 mg - 25 mg

Dosing

Hypertension
  • Dosing: HCTZ 25 - 50 mg/day; Captopril 25 - 150 mg/day
  • May be given once daily or in divided doses
  • Take one hour before meals

Generic / Price

- YES/$

Lotensin HCT® (benazepril + HCTZ)

Dosage forms

Tablet
  • Benazepril - HCTZ
    • 5 mg - 6.25 mg
    • 10 mg - 12.5 mg
    • 20 mg - 12.5 mg
    • 20 mg - 25 mg

Dosing

Hypertension
  • Starting: 10/12.5 mg once daily
  • Maintenance: 5/6.25 - 20/25 mg once daily
  • Max: 20/25 mg once daily
  • Increase dose at intervals of every 2 - 3 weeks
  • May take without regard to food

Generic / Price

- YES/$

Monopril HCT® (fosinopril + HCTZ)

Dosage forms

Tablet
  • Fosinopril - HCTZ
    • 10 mg - 12.5 mg
    • 20 mg - 12.5 mg

Dosing

Hypertension
  • Dosing: HCTZ 12.5 - 50 mg once daily; Fosinopril 10 - 80 mg once daily
  • In trials, the maximum dose used was 40/37.5 mg once daily
  • May take without regard to food

Generic / Price

- YES/$

Other

  • On average, the effect of the combination of 10 mg of fosinopril with 12.5 mg of HCTZ was similar to the effect seen with monotherapy using either 40 mg of fosinopril or 37.5 mg of HCTZ

Uniretic® (moexipril + HCTZ)

Dosage forms

Tablet
  • Moexipril - HCTZ
    • 7.5 mg - 12.5 mg
    • 15 mg - 12.5 mg
    • 15 mg - 25 mg

Dosing

Hypertension
  • Dosing: HCTZ 12.5 - 50 mg/day; Moexipril 7.5 - 30 mg/day
  • May be given once daily or in divided doses
  • Take one hour before a meal

Generic / Price

- YES/$

Vaseretic® (enalapril + HCTZ)

Dosage forms

Tablet
  • Enalapril - HCTZ
    • 5 mg - 12.5 mg
    • 10 mg - 25 mg

Dosing

Hypertension
  • Starting: 10/25 mg/day given once daily or in two divided doses
  • Max: 20/50 mg/day
  • Increase dose at intervals of 2 - 3 weeks
  • May take without regard to food

Generic / Price

- YES/$

Zestoretic® | Prinzide® (lisinopril + HCTZ)

Dosage forms

Tablet
  • Lisinopril - HCTZ
    • 10 mg - 12.5 mg
    • 20 mg - 12.5 mg
    • 20 mg - 25 mg

Dosing

Hypertension
  • Dosing: HCTZ 6.25 - 50 mg/day | Lisinopril 10 - 80 mg/day
  • Typically dosed once daily
  • Increase dose at intervals of 2 - 3 weeks
  • May take without regard to food

Generic / Price

- YES/$



Lotrel® (amlodipine + benazepril)

Dosage forms

Capsule
  • Amlodipine - Benazepril
    • 2.5 mg - 10 mg
    • 5 mg - 10 mg
    • 5 mg - 20 mg
    • 5 mg - 40 mg
    • 10 mg - 20 mg
    • 10 mg - 40 mg

Dosing

Hypertension
  • Starting: 2.5 mg/10 mg once daily
  • Maintenance: 2.5 mg/10 mg - 10 mg/40 mg once daily
  • Max: 10 mg/40 mg once daily
  • May take without regard to food
  • Antihypertensive effect typically seen within 2 weeks

Generic / Price

- YES/$

Prestalia® (amlodipine + perindopril)

Dosage forms

Tablet
  • Perindopril - Amlodipine
    • 3.5 mg - 2.5 mg
    • 7 mg - 5 mg
    • 14 mg - 10 mg

Dosing

Hypertension
  • Starting: 3.5 mg/2.5 mg once daily
  • Maintenance: 3.5 mg/2.5 mg - 14 mg/10 mg once daily
  • Max: 14 mg/10 mg once daily
  • Increase dose at intervals of 1 to 2 weeks
  • May take without regard to food

Generic / Price

- NO/$$$$

Tarka® (verapamil ER + trandolapril)

Dosage forms

Tablet
  • Trandolapril - Verapamil ER
    • 2 mg - 180 mg
    • 1 mg - 240 mg
    • 2 mg - 240 mg
    • 4 mg - 240 mg

Dosing

Hypertension
  • Dosing: Trandolapril is dosed at 1 - 4 mg a day given in one or two divided doses. Verapamil ER is dosed at 120 - 480 mg a day given in one or two divided doses.
  • In trials, Tarka was dosed once daily
  • Take with food

Generic / Price

- YES/$-$$










Pricing legend
  • $ = 0 - $50
  • $$ = $51 - $100
  • $$$ = $101 - $150
  • $$$$ = > $150
  • Pricing based on one month of therapy at standard dosing in an adult
  • Pricing based on information from GoodRX.com®
  • Pricing may vary by region and availability