ACE INHIBITOR DOSING









Benazepril (Lotensin®)

Dosage forms

Tablet
  • 5 mg
  • 10 mg
  • 20 mg
  • 40 mg

Dosing - Adults

Hypertension
  • Starting: 10 mg once daily
  • Maintenance: 20 - 40 mg/day
  • Max: 80 mg/day
  • May give in one or two divided doses
  • May take without regard to food

Dosing - Pediatric

Hypertension (≥ 6 years old)
  • Dosing: 0.2 mg/kg once daily
  • Max: 0.6 mg/kg (max 40 mg) once daily
  • See Lotensin PI [sec 2.3] for instructions on compounding a 2 mg/ml suspension
  • May take without regard to food

Generic / Price

- YES/$

Other

  • Consider starting dose of 5 mg if adding to diuretic
  • If CrCl < 30 ml/min, then starting dose is 5 mg daily. Maximum dose is 40 mg a day.
  • See Lotensin PI [sec 2.3] for instructions on compounding a 2 mg/ml suspension

Captopril (Capoten®)

Dosage forms

Tablet
  • 12.5 mg
  • 25 mg
  • 50 mg
  • 100 mg

Dosing - Adults

Hypertension
  • Starting: 25 mg two to three times a day
  • Maintenance: 25 - 150 mg two to three times a day
  • Max: 450 mg/day
  • Increase dose at 1 - 2 week intervals
  • Take 1 hour before meals. Food decreases absorption.
Heart failure
  • Starting: 25 mg three times a day
  • Maintenance dose: 50 - 100 mg three times a day
  • Increase dose at 2 week intervals
  • Take 1 hour before meals. Food decreases absorption.
Diabetic nephropathy
  • Maintenance dose: 25 mg three times a day
  • Take 1 hour before meals. Food decreases absorption.

Dosing - Pediatric

Hypertension (infants)
  • Starting: 0.05 mg/kg/dose
  • Max: 6 mg/kg/day
  • May given once daily to 4 times a day
  • AAP recommended dosing [2]
  • Take 1 hour before meals. Food decreases absorption.
Hypertension (children)
  • Starting: 0.5 mg/kg/dose
  • Max: 6 mg/kg/day
  • Give in three divided doses
  • AAP recommended dosing [2]
  • Take 1 hour before meals. Food decreases absorption.

Generic / Price

- YES/$-$$

Enalapril | Vasotec® | Epaned®

Dosage forms

Tablet
  • 2.5 mg
  • 5 mg
  • 10 mg
  • 20 mg
Solution (Epaned®)
  • 1 mg/ml
  • Comes in 150 ml bottle

Dosing - Adults

Hypertension
  • Starting: 5 mg once daily
  • Maintenance: 10 - 40 mg/day
  • Max: 40 mg/day
  • May be given in one or two divided doses
  • May take without regard to food
Heart failure
  • Starting: 2.5 mg twice a day
  • Maintenance: 2.5 - 20 mg twice a day
  • Max: 40 mg/day
  • Titrate over a period of a few days or weeks
  • May take without regard to food
Asymptomatic left ventricular dysfunction
  • Starting: 2.5 mg twice a day
  • Target: 10 mg twice a day
  • Titrate as tolerated
  • May take without regard to food

Dosing - Pediatric

Hypertension (≥ 1 month)
  • Starting: 0.08 mg/kg (max 5 mg) once daily
  • Max: 0.60 mg/kg/day (max 40 mg)
  • May give once daily or in two divided doses
  • AAP recommended dosing [2]
  • See Vasotec PI for instructions on compounding a 1 mg/ml suspension
  • May take without regard to food

Generic / Price

  • Tablet - YES/$
  • Solution (Epaned®) - NO/$$$$

Other

  • Consider starting dose of 2.5 mg if adding to a diuretic
  • If CrCl is ≤ 30 ml/min, starting dose is 2.5 mg once daily
  • See Vasotec PI for instructions on compounding a 1 mg/ml suspension

Fosinopril (Monopril®)

Dosage forms

Tablet
  • 10 mg
  • 20 mg
  • 40 mg

Dosing - Adults

Hypertension
  • Starting: 10 mg once daily
  • Maintenance: 20 - 40 mg/day
  • Max: 80 mg/day
  • May be given in one or two divided doses
  • May take without regard to food
Heart failure
  • Starting dose: 10 mg once daily
  • Maintenance: 20 - 40 mg once daily
  • Max: 40 mg once daily
  • May take without regard to food

Dosing - Pediatric

Hypertension (≥ 6 years old)
  • Starting: 0.1 mg/kg (max 5 mg) once daily
  • Max: 40 mg/day
  • AAP recommended dosing [2]
  • May take without regard to food
Hypertension (≥ 50 kg)
  • Starting: 5 mg/day
  • Max: 40 mg/day
  • AAP recommended dosing [2]
  • May take without regard to food

Generic / Price

- YES/$

Lisinopril | Zestril® | Prinivil® | Qbrelis®

Dosage forms

Tablet
  • 2.5 mg
  • 5 mg
  • 10 mg
  • 20 mg
  • 30 mg
  • 40 mg
Solution (Qbrelis®)
  • 1 mg/ml
  • Comes in 150 ml bottle

Dosing - Adults

Hypertension
  • Starting: 10 mg once daily
  • Maintenance: 20 - 40 mg once daily
  • Max: 40 mg once daily
  • May take without regard to food
Heart failure
  • Starting: 5 mg once daily
  • Maintenance: 5 - 40 mg once daily
  • Max: 40 mg once daily
  • May take without regard to food

Dosing - Pediatric

Hypertension (≥ 6 years old)
  • Starting: 0.07 mg/kg (max 5 mg) once daily
  • Max: 0.61 mg/kg (max 40 mg) once daily
  • See Prinivil PI sec 2.5 for instructions on compounding a 1 mg/ml suspension
  • May take without regard to food

Generic / Price

  • Tablet - YES/$
  • Solution (Qbrelis®) - NO/$$$$

Other

  • Lower starting doses may be appropriate in patients taking diuretics
  • CrCl 10 - 30 ml/min - start with half the recommended starting dose
  • CrCl < 10 ml/min - starting dose is 2.5 mg once daily
  • See Prinivil PI sec 2.5 for instructions on compounding a 1 mg/ml suspension

Moexipril (Univasc®)

Dosage forms

Tablet
  • 7.5 mg
  • 15 mg

Dosing

Hypertension
  • Starting: 7.5 mg once daily
  • Maintenance: 7.5 - 30 mg/day
  • Max: 60 mg/day
  • May give in one or two divided doses
  • Take one hour before meals. Food decreases absorption.

Generic / Price

- YES/$

Other

  • Lower starting dose may be appropriate in patients taking diuretics
  • CrCl ≤ 40 ml/min - starting dose is 3.75 mg once daily. Maximum dose is 15 mg a day.

Perindopril (Aceon®)

Dosage forms

Tablet
  • 2 mg
  • 4 mg
  • 8 mg

Dosing

Hypertension
  • Starting: 4 mg once daily
  • Maintenance: 4 - 8 mg/day
  • Max: 16 mg/day
  • May give in one or two divided doses
  • May take without regard to food
Stable coronary artery disease
  • Starting: 4 mg once daily for 2 weeks
  • Maintenance: 8 mg once daily
  • Elderly patients should be started at 2 mg once daily
  • May take without regard to food

Generic / Price

- YES/$

Other

  • Lower starting doses may be appropriate in the elderly and in patients taking diuretics
  • Not recommended if CrCl < 30 ml/min. For lesser degrees of renal impairment, starting dose should be 2 mg and dose should not exceed 8 mg.

Quinapril (Accupril®)

Dosage forms

Tablet
  • 5 mg
  • 10 mg
  • 20 mg
  • 40 mg

Dosing - Adults

Hypertension
  • Starting: 10 - 20 mg once daily
  • Maintenance: 20 - 80 mg/day
  • Max: 80 mg/day
  • May be given in one or two divided doses
  • May take without regard to food
Heart failure
  • Starting: 5 mg twice a day
  • Maintenance: 10 - 20 mg twice a day
  • Increase dose at 1 week intervals
  • May take without regard to food

Dosing - Pediatric

Hypertension (age not specified by AAP)
  • Starting: 5 mg/day
  • Max: 80 mg/day
  • AAP recommended dosing [2]
  • May take without regard to food

Generic / Price

- YES/$

Other

  • Lower starting dose may be appropriate in patients taking diuretics
  • CrCl 30 - 60 ml/min - starting dose is 5 mg a day
  • CrCl 10 - 30 ml/min - starting dose is 2.5 mg a day
  • CrCl < 10 ml/min - has not been studied

Ramipril (Altace®)

Dosage forms

Tablet and capsule
  • 1.25 mg
  • 2.5 mg
  • 5 mg
  • 10 mg

Dosing - Adults

Hypertension
  • Starting: 2.5 mg once daily
  • Maintenance: 2.5 - 20 mg/day
  • Max: 20 mg/day
  • May give in one or two divided doses
  • May take without regard to food
Heart failure
  • Starting: 2.5 mg twice a day
  • Target: 5 mg twice a day
  • Increase dose at 3 weeks intervals
  • May take without regard to food

Dosing - Pediatric

Hypertension (age not specified by AAP)
  • Starting: 1.6 mg/m2/day
  • Max: 6 mg/m2/day
  • AAP recommended dosing [2]
  • May take without regard to food

Generic / Price

- YES/$

Other

  • CrCl < 40 ml/min - starting dose is 1.25 mg once daily. Maximum dose is 5 mg a day.

Trandolapril (Mavik®)

Dosage forms

Tablet
  • 1 mg
  • 2 mg
  • 4 mg

Dosing

Hypertension
  • Starting (nonblack): 1 mg once daily
  • Starting (black): 2 mg once daily
  • Maintenance: 2 - 4 mg/day
  • Max: 8 mg/day
  • May be given in one or two divided doses
  • May take without regard to food
Heart failure
  • Starting: 1 mg once daily
  • Target: 4 mg once daily
  • May take without regard to food

Generic / Price

- YES/$

Other

  • Lower starting dose may be appropriate in patients taking diuretics
  • CrCl < 30 ml/min - starting dose is 0.5 mg a day
  • Cirrhosis - starting dose is 0.5 mg a day



Accuretic® | Quinaretic® (quinapril + HCTZ)

Dosage forms

Tablet
  • Quinapril - HCTZ
    • 10 mg - 12.5 mg
    • 20 mg - 12.5 mg
    • 20 mg - 25 mg

Dosing

Hypertension
  • Dosing: 10/12.5 mg - 40/25 mg once daily
  • Max: 40/25 mg once daily
  • Increase dose at intervals of 2 - 3 weeks
  • May take without regard to food

Generic / Price

- YES/$

Capozide® (captopril + HCTZ)

Dosage forms

Tablet
  • Captopril - HCTZ
    • 25 mg - 15 mg
    • 25 mg - 25 mg
    • 50 mg - 15 mg
    • 50 mg - 25 mg

Dosing

Hypertension
  • Dosing: HCTZ 25 - 50 mg/day; Captopril 25 - 150 mg/day
  • May be given once daily or in divided doses
  • Take one hour before meals

Generic / Price

- YES/$

Lotensin HCT® (benazepril + HCTZ)

Dosage forms

Tablet
  • Benazepril - HCTZ
    • 5 mg - 6.25 mg
    • 10 mg - 12.5 mg
    • 20 mg - 12.5 mg
    • 20 mg - 25 mg

Dosing

Hypertension
  • Starting: 10/12.5 mg once daily
  • Maintenance: 5/6.25 - 20/25 mg once daily
  • Max: 20/25 mg once daily
  • Increase dose at intervals of every 2 - 3 weeks
  • May take without regard to food

Generic / Price

- YES/$

Monopril HCT® (fosinopril + HCTZ)

Dosage forms

Tablet
  • Fosinopril - HCTZ
    • 10 mg - 12.5 mg
    • 20 mg - 12.5 mg

Dosing

Hypertension
  • Dosing: HCTZ 12.5 - 50 mg once daily; Fosinopril 10 - 80 mg once daily
  • In trials, the maximum dose used was 40/37.5 mg once daily
  • May take without regard to food

Generic / Price

- YES/$

Other

  • On average, the effect of the combination of 10 mg of fosinopril with 12.5 mg of HCTZ was similar to the effect seen with monotherapy using either 40 mg of fosinopril or 37.5 mg of HCTZ

Uniretic® (moexipril + HCTZ)

Dosage forms

Tablet
  • Moexipril - HCTZ
    • 7.5 mg - 12.5 mg
    • 15 mg - 12.5 mg
    • 15 mg - 25 mg

Dosing

Hypertension
  • Dosing: HCTZ 12.5 - 50 mg/day; Moexipril 7.5 - 30 mg/day
  • May be given once daily or in divided doses
  • Take one hour before a meal

Generic / Price

- YES/$

Vaseretic® (enalapril + HCTZ)

Dosage forms

Tablet
  • Enalapril - HCTZ
    • 5 mg - 12.5 mg
    • 10 mg - 25 mg

Dosing

Hypertension
  • Starting: 10/25 mg/day given once daily or in two divided doses
  • Max: 20/50 mg/day
  • Increase dose at intervals of 2 - 3 weeks
  • May take without regard to food

Generic / Price

- YES/$

Zestoretic® | Prinzide® (lisinopril + HCTZ)

Dosage forms

Tablet
  • Lisinopril - HCTZ
    • 10 mg - 12.5 mg
    • 20 mg - 12.5 mg
    • 20 mg - 25 mg

Dosing

Hypertension
  • Dosing: HCTZ 6.25 - 50 mg/day | Lisinopril 10 - 80 mg/day
  • Typically dosed once daily
  • Increase dose at intervals of 2 - 3 weeks
  • May take without regard to food

Generic / Price

- YES/$



Lotrel® (amlodipine + benazepril)

Dosage forms

Capsule
  • Amlodipine - Benazepril
    • 2.5 mg - 10 mg
    • 5 mg - 10 mg
    • 5 mg - 20 mg
    • 5 mg - 40 mg
    • 10 mg - 20 mg
    • 10 mg - 40 mg

Dosing

Hypertension
  • Starting: 2.5 mg/10 mg once daily
  • Maintenance: 2.5 mg/10 mg - 10 mg/40 mg once daily
  • Max: 10 mg/40 mg once daily
  • May take without regard to food
  • Antihypertensive effect typically seen within 2 weeks

Generic / Price

- YES/$

Prestalia® (amlodipine + perindopril)

Dosage forms

Tablet
  • Perindopril - Amlodipine
    • 3.5 mg - 2.5 mg
    • 7 mg - 5 mg
    • 14 mg - 10 mg

Dosing

Hypertension
  • Starting: 3.5 mg/2.5 mg once daily
  • Maintenance: 3.5 mg/2.5 mg - 14 mg/10 mg once daily
  • Max: 14 mg/10 mg once daily
  • Increase dose at intervals of 1 to 2 weeks
  • May take without regard to food

Generic / Price

- NO/$$$$

Tarka® (verapamil ER + trandolapril)

Dosage forms

Tablet
  • Trandolapril - Verapamil ER
    • 2 mg - 180 mg
    • 1 mg - 240 mg
    • 2 mg - 240 mg
    • 4 mg - 240 mg

Dosing

Hypertension
  • Dosing: Trandolapril is dosed at 1 - 4 mg a day given in one or two divided doses. Verapamil ER is dosed at 120 - 480 mg a day given in one or two divided doses.
  • In trials, Tarka was dosed once daily
  • Take with food

Generic / Price

- YES/$-$$










Pricing legend
  • $ = 0 - $50
  • $$ = $51 - $100
  • $$$ = $101 - $150
  • $$$$ = > $150
  • Pricing based on one month of therapy at standard dosing in an adult
  • Pricing based on information from GoodRX.com®
  • Pricing may vary by region and availability