ALPHA-2 AGONIST DOSING









Clonidine (Catapres®)

Dosage forms

Tablet
  • 0.1 mg
  • 0.2 mg
  • 0.3 mg

Dosing

Hypertension
  • Starting: 0.1 mg twice a day
  • Maintenance: 0.1 - 0.3 mg twice a day
  • Max: 2.4 mg/day (doses this high are not typical)
  • Increase dose by 0.1 mg a day at weekly intervals
  • May take without regard to food

Generic / Price

- YES/$

Clonidine (Catapres-TTS®)

Dosage forms

Patch
  • TTS-1 delivers 0.1 mg per day for 7 days
  • TTS-2 delivers 0.2 mg per day for 7 days
  • TTS-3 delivers 0.3 mg per day for 7 days

Dosing

Hypertension
  • Starting: One TTS-1 patch for 7 days
  • Maintenance: Increase up to two TTS-3 patches as needed
  • Max: Two TTS-3 patches (0.6 mg/day)
  • Increase dose at 1 - 2 week intervals

Generic / Price

- YES/$-$$

Other

  • One patch is good for 7 days
  • Apply patch to hairless, intact skin of upper outer arm or chest
  • When initiating patch, it may take 2 - 3 days for blood pressure effect to be realized. Patients may need to continue current doses of BP meds for the first 2 - 3 days when applicable.
  • Apply each new patch to a different area of skin
  • Remove old patch before applying new patch
  • Normal exposure to water should not affect patch
  • Do not wear during MRI or electrical cardioversion

Methyldopa (Aldomet®)

Dosage forms

Tablet
  • 250 mg
  • 500 mg

Dosing

Hypertension
  • Starting: 250 mg two to three times a day
  • Maintenance: 500 - 2000 mg/day
  • Max: 3000 mg/day
  • Give in two to four divided doses
  • Increase dose at intervals of ≥ 2 days
  • May take without regard to food

Generic / Price

- YES/$

Other

  • Tolerance may develop in some patients after 2 - 3 months of therapy



Aldoril® (methyldopa + HCTZ)

Dosage forms

Tablet
  • Methyldopa - HCTZ
    • 250 mg - 15 mg
    • 250 mg - 25 mg

Dosing

Hypertension
  • Starting: 250/15 mg two to three times a day OR 250/25 mg twice a day
  • Max: Methyldopa - 3000 mg/day; HCTZ 50 mg/day
  • May take without regard to food

Generic / Price

- YES/$

Clorpres® (clonidine + chlorthalidone)

Dosage forms

Tablet
  • Clonidine - Chlorthalidone
    • 0.1 mg - 15 mg
    • 0.2 mg - 15 mg
    • 0.3 mg - 15 mg

Dosing

Hypertension
  • Dosing: 0.1/15 - 0.6/30 mg/day
  • Max: 0.6/30 mg/day
  • May be given once daily or in 2 divided doses
  • Chlorthalidone should be taken with food

Generic / Price

- NO/$$-$$$










Pricing legend
  • $ = 0 - $50
  • $$ = $51 - $100
  • $$$ = $101 - $150
  • $$$$ = > $150
  • Pricing based on one month of therapy at standard dosing in an adult
  • Pricing based on information from GoodRX.com®
  • Pricing may vary by region and availability