ALPHA BLOCKER DOSING









Alfuzosin (Uroxatral®)

Dosage forms

Tablet, extended-release
  • 10 mg

Dosing

Benign prostatic hyperplasia (BPH)
  • Dosing: 10 mg once daily
  • Max: 10 mg once daily
  • Take with food. Food increases absorption.

Generic / Price

- YES/$

Other

  • Do not crush or chew tablets
  • Take with the same meal each day
  • Drug absorption is 50% lower when taken under fasting conditions

Doxazosin (Cardura®)

Dosage forms

Tablet
  • 1 mg
  • 2 mg
  • 4 mg
  • 8 mg

Dosing

Benign prostatic hyperplasia (BPH)
  • Starting: 1 mg once daily
  • Maintenance: 1 - 8 mg once daily
  • Max: 8 mg once daily
  • Increase dose by doubling current dosage at intervals of 1 - 2 weeks
  • May take without regard to food
Hypertension
  • Starting: 1 mg once daily
  • Maintenance: 1 - 16 mg once daily
  • Max: 16 mg once daily
  • Increase dose by doubling current dosage
  • May take without regard to food

Generic / Price

- YES/$

Other

  • Postural hypotension may occur when increasing dose. More common with doses > 4 mg.

Doxazosin (Cardura® XL)

Dosage forms

Tablet, extended-release
  • 4 mg
  • 8 mg

Dosing

Benign prostatic hyperplasia (BPH)
  • Starting: 4 mg once daily
  • Maintenance: 4 - 8 mg once daily
  • Max: 8 mg once daily
  • Increase at intervals of 3 - 4 weeks
  • Take with breakfast. Food increases absorption.

Generic / Price

- NO/$$$$

Other

  • Do not cut, crush, or chew tablet
  • If therapy is discontinued for several days, restart at 4 mg dose
  • When switching from Cardura® to Cardura® XL, start with 4 mg dose
  • Nonabsorbable tablet shell may be seen in stool. This is normal.

Prazosin (Minipress®)

Dosage forms

Capsule
  • 1 mg
  • 2 mg
  • 5 mg

Dosing

Hypertension
  • Starting: 1 mg two to three times a day
  • Maintenance: 6 - 15 mg/day
  • Max: 40 mg/day
  • Give in 2 - 3 divided doses
  • May take without regard to food

Generic / Price

- YES/$-$$

Other

  • Doses above 20 mg a day do not typically increase efficacy

Silodosin (Rapaflo®)

Dosage forms

Capsule
  • 4 mg
  • 8 mg

Dosing

Benign prostatic hyperplasia (BPH)
  • Dosing: 8 mg once daily
  • Max: 8 mg once daily
  • Take with a meal. Food decreases absorption. In trials, silodosin was always taken with food.

Generic / Price

- YES/$

Other

  • Capsules may be opened and sprinkled on applesauce. Applesauce should be swallowed immediately and followed with 8 oz of water.

Tamsulosin (Flomax®)

Dosage forms

Capsule
  • 0.4 mg

Dosing

Benign prostatic hyperplasia (BPH)
  • Starting: 0.4 mg once daily
  • Maintenance: 0.4 - 0.8 mg once daily
  • Max: 0.8 mg once daily
  • Increase dose at intervals of 2 - 4 weeks
  • Take one-half hour after the same meal every day. Food slows absorption and may decrease side effects.

Generic / Price

- YES/$

Other

  • Do not open, crush, or chew capsules
  • If therapy is stopped for several days, restart medication at 0.4 mg dose

Terazosin (Hytrin®)

Dosage forms

Capsule
  • 1 mg
  • 2 mg
  • 5 mg
  • 10 mg

Dosing

Benign prostatic hyperplasia (BPH)
  • Starting: 1 mg once daily at bedtime
  • Target: 10 mg once daily
  • Max: 20 mg once daily
  • Increase dose in stepwise fashion: 2 mg - 5 mg - 10 mg
  • May take without regard to food
Hypertension
  • Starting: 1 mg once daily at bedtime
  • Maintenance: 1 - 5 mg/day
  • Max: 20 mg/day
  • May be given once daily or in 2 divided doses
  • Increase dose by doubling current dosage
  • May take without regard to food

Generic / Price

- YES/$

Other

  • Do not open, crush, or chew capsules
  • If therapy is stopped for several days, restart medication at 1 mg
  • It may take 4 - 6 weeks at the 10 mg dose for full BPH symptom response



Jalyn® (tamsulosin + dutasteride)

Dosage forms

Capsule
  • Dutasteride - Tamsulosin
    • 0.5 mg - 0.4 mg

Dosing

Benign prostatic hyperplasia (BPH)
  • Dosing: 0.5/0.4 mg once daily
  • Take approximately 30 minutes after the same meal each day. Food slows absorption and may decrease side effects.

Generic / Price

- YES/$$

Other

  • Swallow capsule whole. Do not open or chew. Contact with the contents of the Jalyn capsule may result in irritation of the oropharyngeal mucosa.







  • NOTE: Information on metabolic pathways presented here is from the manufacurer's PI, FDA website, and a handful of published reviews. Other metabolic pathways may exist; therefore, the information is not meant to be all-inclusive.
Metabolism and clearance
Drug CYP2C19 CYP2D6 CYP3A4 P-glycoprotein
Alfuzosin - - Substrate -
Doxazosin Substrate Substrate Substrate Inhibitor
Prazosin - - - Substrate and inducer
Silodosin - - Substrate Substrate
Tamsulosin - Substrate Substrate -
Terazosin Not well-defined



Pricing legend
  • $ = 0 - $50
  • $$ = $51 - $100
  • $$$ = $101 - $150
  • $$$$ = > $151
  • Pricing based on one month of therapy at standard dosing in an adult
  • Pricing based on information from GoodRX.com®
  • Pricing may vary by region and availability