AMYLIN ANALOGS


















  • Values are expressed as change from baseline. Baseline A1C ∼ 9.0%.
  • Insulin doses (basal and premeal) did not change significantly in either group during the trial
  • Reference [1]
Effects of Pramlintide on Type 1 DM when added to insulin for 6 months
Pramlintide 60 mcg three times a day
(N=164)
Placebo
(N=154)
Change in HgA1C -0.44%
-0.19%







  • Values are expressed as change from baseline. Baseline A1C ∼ 9.1%.
  • Insulin doses (basal and premeal) did not change significantly in either group during the trial
  • Reference [1]
Effects of Pramlintide on Type 2 DM when added to insulin and oral meds for 6 months
Pramlintide 120 mcg before meals
(N=166)
Placebo
(N=161)
Change in HgA1C -0.66% -0.32%








  • Trials lasting 26 - 52 weeks
  • Reference [1]
Trials in type one diabetics
Side effect Pramlintide 30 - 60 mcg 3 times a day Placebo
Nausea 48% 17%
Decreased appetite 17% 2%
Vomiting 11% 7%

  • Trials lasting 26 - 52 weeks
  • Reference [1]
Trials in type two diabetics
Side effect Pramlintide 120 mcg 2 times a day Placebo
Nausea 28% 12%
Decreased appetite 9% 2%
Vomiting 8% 4%













Pramlintide


Metabolism and clearance