ANGIOTENSIN II RECEPTOR BLOCKER (ARB) DOSING









Azilsartan (Edarbi®)

Dosage forms

Tablet
  • 40 mg
  • 80 mg

Dosing

Hypertension (adults)
  • Starting: 80 mg once daily
  • Maintenance: 40 - 80 mg once daily
  • Max: 80 mg once daily
  • Consider starting dose of 40 mg a day if on high doses of diuretics
  • May take without regard to food
Kidney disease
Liver disease
  • Child-Pugh A or B: no dose adjustment necessary
  • Child-Pugh C: has not been studied

Generic / Price

- NO/$$$$

Candesartan (Atacand®)

Dosage forms

Tablet
  • 4 mg
  • 8 mg
  • 16 mg
  • 32 mg

Dosing

Hypertension (adults)
  • Starting: 16 mg once daily
  • Maintenance: 8 - 32 mg/day
  • Max: 32 mg/day
  • May be given in one or two divided doses
  • Lower starting dose may be appropriate in patients taking diuretics
  • Most of the antihypertensive effect occurs within the first 2 weeks, and maximum reduction is seen in 4 - 6 weeks
  • May take without regard to food
Heart failure (adults)
  • Starting: 4 mg once daily
  • Target dose: 32 mg once daily
  • Max: 32 once daily
  • Dose may be doubled every 2 weeks as tolerated
  • May take without regard to food
Hypertension (1 to 5 years old)
  • Starting: 0.20 mg/kg/day
  • Maintenance: 0.05 to 0.4 mg/kg/day
  • May be given in one or two divided doses
  • See Atacand PI [sec 2.2] for instructions on compounding a 1 mg/ml suspension
  • May take without regard to food
Hypertension (6 to <17 years old)
  • Starting (< 50 kg): 4 - 8 mg/day
  • Starting (≥ 50 kg): 8 - 16 mg/day
  • Maintenance (< 50 kg): 2 - 16 mg/day
  • Maintenance (≥ 50 kg): 4 - 32 mg/day
  • May be given in one or two divided doses
  • See Atacand PI [sec 2.2] for instructions on compounding a 1 mg/ml suspension
  • May take without regard to food
Kidney disease
Liver disease
  • Child-Pugh B: starting dose should be 8 mg/day when treating hypertension
  • Child-Pugh C: has not been studied

Generic / Price

- YES/$

Irbesartan (Avapro®)

Dosage forms

Tablet
  • 75 mg
  • 150 mg
  • 300 mg

Dosing

Hypertension (adults)
  • Starting: 150 mg once daily
  • Maintenance: 150 - 300 mg once daily
  • Max: 300 mg once daily
  • A starting dose of 75 mg once daily is recommended in patients who are volume and salt depleted (e.g. aggressive diuretic therapy or hemodialysis)
  • May take without regard to food
Diabetic nephropathy (adults)
  • Target dose: 300 mg once daily
  • A starting dose of 75 mg once daily is recommended in patients who are volume and salt depleted (e.g. aggressive diuretic therapy or hemodialysis)
  • May take without regard to food
Hypertension (6 - 12 years old)
  • Starting: 75 mg once daily
  • Max: 150 mg once daily
  • May take without regard to food
  • AAP recommended dosing [2]
Hypertension (≥ 13 years old)
  • Starting: 150 mg once daily
  • Max: 300 mg once daily
  • May take without regard to food
  • AAP recommended dosing [2]
Kidney disease
Liver disease
  • No dose adjustment necessary

Generic / Price

- YES/$

Losartan (Cozaar®)

Dosage forms

Tablet
  • 25 mg
  • 50 mg
  • 100 mg

Dosing

Hypertension (adults)
  • Starting: 50 mg once daily
  • Maintenance: 25 - 100 mg once daily
  • Max: 100 mg once daily
  • A starting dose of 25 mg is recommended in patients with volume depletion (e.g. diuretic therapy)
  • Blood pressure effect occurs within one week, but maximum effect may take 3 - 6 weeks
  • May take without regard to food
Diabetic nephropathy (adults)
  • Starting: 50 mg once daily
  • Maintenance: 50 - 100 mg once daily
  • Max: 100 mg once daily
  • May take without regard to food
Hypertension with left ventricular hypertrophy (adults)
  • Starting: 50 mg once daily
  • Maintenance: 50 - 100 mg once daily
  • Max: 100 mg once daily
  • Concomitant HCTZ is recommended at a dose of 12.5 mg (50 mg dose) or 25 mg (100 mg dose)
  • May take without regard to food
Hypertension (≥ 6 years old)
  • Starting: 0.7 mg/kg (max 50 mg) once daily
  • Max: 1.4 mg/kg (max 100 mg) once daily
  • Not recommended in pediatric patients with GFR < 30 ml/min
  • See Cozaar PI [sec 2.5] for instructions on compounding a 2.5 mg/ml suspension
  • May take without regard to food
Kidney disease
Liver disease
  • Child-Pugh A or B: use a starting dose of 25 mg once daily
  • Child-Pugh C: has not been studied

Generic / Price

- YES/$

Olmesartan (Benicar®)

Dosage forms

Tablet
  • 5 mg
  • 20 mg
  • 40 mg

Dosing

Hypertension (adults)
  • Starting: 20 mg once daily
  • Maintenance: 20 - 40 mg once daily
  • Max: 40 mg once daily
  • A lower starting dose may be appropriate in patients with volume depletion (e.g. diuretic therapy)
  • May take without regard to food
Hypertension (≥ 6 years old)
  • 44 lbs (20 kg) to less than 77 lbs (35 kg)
    • Starting: 10 mg once daily
    • Max: 20 mg once daily
  • Greater than or equal to 77 lbs (35 kg)
    • Starting: 20 mg once daily
    • Max: 40 mg once daily
  • Increase dose at intervals of 2 weeks
  • See Benicar PI [sec 2.2] for instructions on compounding a 2 mg/ml suspension
  • May take without regard to food
Kidney disease
Liver disease
  • No initial dose adjustment is recommended

Generic / Price

- YES/$

Telmisartan (Micardis®)

Dosage forms

Tablet
  • 20 mg
  • 40 mg
  • 80 mg

Dosing

Hypertension (adults)
  • Starting: 40 mg once daily
  • Maintenance: 20 - 80 mg once daily
  • Max: 80 mg once daily
  • Most of the blood pressure effect is seen within 2 weeks, and maximum effect occurs within 4 weeks
  • May take without regard to food
Cardiovascular risk reduction (adults)
  • Dosing: 80 mg once daily
  • May take without regard to food
Kidney disease
Liver disease
  • Monitor carefully and uptitrate slowly in patients with biliary obstructive disorders or hepatic insufficiency

Generic / Price

- YES/$

Valsartan (Diovan®)

Dosage forms

Tablet
  • 40 mg
  • 80 mg
  • 160 mg
  • 320 mg

Dosing

Hypertension (adults)
  • Starting: 80 - 160 mg once daily
  • Maintenance: 80 - 320 mg once daily
  • Max: 320 mg once daily
  • Blood pressure effect is seen within 2 weeks, and maximum effect occurs within 4 weeks
  • May take without regard to food
Heart failure (adults)
  • Starting: 40 mg twice daily
  • Maintenance: 80 - 160 mg twice daily
  • Max: 160 mg twice daily
  • May take without regard to food
Post-Myocardial infarction (adults)
  • Starting: 20 mg twice daily
  • Maintenance: 40 - 160 mg twice daily
  • Max: 160 mg twice daily
  • May be initiated as early as 12 hours after a myocardial infarction
  • May take without regard to food
Hypertension (1 - 16 years old)
  • Starting: 1 mg/kg (max 40 mg) once daily
  • Max: 4 mg/kg (max 160 mg) once daily
  • A starting dose of 2 mg/kg may be considered in cases when a greater reduction of blood pressure is needed
  • Has not been studied in pediatric patients with GFR < 30 ml/min
  • See Diovan PI [sec 2.1] for instructions on compounding a 4 mg/ml suspension
  • When the suspension is replaced by a tablet, the dose of valsartan may need to be increased. The bioavailability of valsartan in the suspension is 1.6 times that of the tablet.
  • May take without regard to food
Kidney disease
  • CrCl ≥ 30 ml/min: no dose adjustment necessary
  • CrCl < 30 ml/min: has not been studied
  • See ARBs in kidney disease for more
Liver disease
  • Child-Pugh A or B: no dose adjustment necessary
  • Child-Pugh C: has not been studied

Generic / Price

- YES/$



Atacand HCT® (candesartan + HCTZ)

Dosage forms

Tablet
  • Candesartan - HCTZ
    • 16 mg - 12.5 mg
    • 32 mg - 12.5 mg
    • 32 mg - 25 mg

Dosing

Hypertension
  • Dosing: HCTZ 12.5 - 50 mg/day | Candesartan 8 - 32 mg/day
  • May be given once daily or in two divided doses
  • Maximal effect seen within 4 weeks
  • May take without regard to food

Generic / Price

- YES/$$-$$$

Avalide® (irbesartan + HCTZ)

Dosage forms

Tablet
  • Irbesartan - HCTZ
    • 150 mg - 12.5 mg
    • 300 mg - 12.5 mg

Dosing

Hypertension
  • Starting: 150/12.5 mg once daily
  • Max: 300/25 mg once daily
  • Titrate dose at intervals of 1 - 2 weeks
  • May take without regard to food

Generic / Price

- YES/$

Benicar HCT® (olmesartan + HCTZ)

Dosage forms

Tablet
  • Olmesartan - HCTZ
    • 20 mg - 12.5 mg
    • 40 mg - 12.5 mg
    • 40 mg - 25 mg

Dosing

Hypertension
  • Starting: 20/12.5 - 40/12.5 mg once daily
  • Max: 40/25 mg once daily
  • May take without regard to food

Generic / Price

- YES/$

Diovan HCT® (valsartan + HCTZ)

Dosage forms

Tablet
  • Valsartan - HCTZ
    • 80 mg - 12.5 mg
    • 160 mg - 12.5 mg
    • 160 mg - 25 mg
    • 320 mg - 12.5 mg
    • 320 mg - 25 mg

Dosing

Hypertension
  • Starting: 160/12.5 mg once daily
  • Max: 320/25 mg once daily
  • Titrate dose at intervals of 1 - 2 weeks
  • Maximum effect seen within 2 - 4 weeks
  • May take without regard to food

Generic / Price

- YES/$

Edarbyclor® (azilsartan + chlorthalidone)

Dosage forms

Tablet
  • Azilsartan - Chlorthalidone
    • 40 mg - 12.5 mg
    • 40 mg - 25 mg

Dosing

Hypertension
  • Starting: 40/12.5 mg once daily
  • Max: 40/25 mg once daily
  • Increase dose if needed after 2 - 4 weeks
  • Most of the antihypertensive effect is seen within 1 - 2 weeks
  • May take without regard to food

Generic / Price

- NO/$$$$

Hyzaar® (losartan + HCTZ)

Dosage forms

Tablet
  • Losartan - HCTZ
    • 50 mg - 12.5 mg
    • 100 mg - 12.5 mg
    • 100 mg - 25 mg

Dosing

Hypertension
  • Starting: 50/12.5 mg once daily
  • Max: 100/25 mg once daily
  • Increase dose at intervals of 3 weeks
  • May take without regard to food
Hypertension with left ventricular hypertrophy
  • Starting: 50/12.5 mg once daily
  • Max: 100/25 mg once daily
  • May take without regard to food

Generic / Price

- YES/$

Micardis HCT® (telmisartan + HCTZ)

Dosage forms

Tablet
  • Telmisartan - HCTZ
    • 40 mg - 12.5 mg
    • 80 mg - 12.5 mg
    • 80 mg - 25 mg
    • Comes in sealed blister pack of 30 tablets

Dosing

Hypertension
  • Starting: 80/12.5 mg once daily
  • Max: 160/25 mg once daily
  • Titrate dose at intervals of 2 - 4 weeks
  • Do not remove tablet from blister pack until ready to take
  • May take without regard to food

Generic / Price

- YES/$

Azor® (amlodipine + olmesartan)

Dosage forms

Tablet
  • Amlodipine - Olmesartan
    • 5 mg - 20 mg
    • 5 mg - 40 mg
    • 10 mg - 20 mg
    • 10 mg - 40 mg

Dosing

Hypertension
  • Starting: 5 mg/20 mg once daily
  • Maintenance: 5 mg/20 mg - 10 mg/40 mg once daily
  • Max: 10 mg/40 mg once daily
  • Titrate dose at intervals of 1 - 2 weeks
  • May take without regard to food

Generic / Price

- YES/$

Exforge® (amlodipine + valsartan)

Dosage forms

Tablet
  • Amlodipine - Valsartan
    • 5 mg - 160 mg
    • 5 mg - 320 mg
    • 10 mg - 160 mg
    • 10 mg - 320 mg

Dosing

Hypertension
  • Starting: 5 mg/160 mg once daily
  • Maintenance: 5 mg/160 mg - 10 mg/320 mg once daily
  • Max: 10 mg/320 mg once daily
  • Full antihypertensive effect typically seen within 2 weeks
  • May take without regard to food

Generic / Price

- YES/$-$$

Twynsta® (amlodipine + telmisartan)

Dosage forms

Tablet
  • Telmisartan - Amlodipine
    • 40 mg - 5 mg
    • 40 mg - 10 mg
    • 80 mg - 5 mg
    • 80 mg - 10 mg

Dosing

Hypertension
  • Starting: 40 mg/5 mg once daily
  • Maintenance: 40 mg/5 mg - 80 mg/10 mg once daily
  • Max: 80 mg/10 mg once daily
  • Most of the antihypertensive effect is seen within 2 weeks
  • May take without regard to food

Generic / Price

- YES/$$

Exforge HCT® (amlodipine + valsartan + HCTZ)

Dosage forms

Tablet
  • Amlodipine - Valsartan - HCTZ
    • 5 mg - 160 mg - 12.5 mg
    • 5 mg - 160 mg - 25 mg
    • 10 mg - 160 mg - 12.5 mg
    • 10 mg - 160 mg - 25 mg
    • 10 mg - 320 mg - 25 mg

Dosing

Hypertension
  • Starting: 5/160/12.5 once daily
  • Maintenance: 5/160/12.5 mg - 10/320/25 mg once daily
  • Max: 10/320/25 mg once daily
  • Titrate dose at intervals of 2 weeks
  • Full antihypertensive effect is seen after 2 weeks
  • May take without regard to food

Generic / Price

- YES/$-$$

Tribenzor® (amlodipine + olmesartan + HCTZ)

Dosage forms

Tablet
  • Amlodipine - Olmesartan - HCTZ
    • 5 mg - 20 mg - 12.5 mg
    • 5 mg - 40 mg - 12.5 mg
    • 5 mg - 40 mg - 25 mg
    • 10 mg - 40 mg - 12.5 mg
    • 10 mg - 40 mg - 25 mg

Dosing

Hypertension
  • Starting: 5/20/12.5 mg once daily
  • Maintenance: 5/20/12.5 mg - 10/40/25 mg once daily
  • Max: 10/40/25 mg once daily
  • Titrate dose at intervals of 2 weeks
  • May take without regard to food

Generic / Price

- YES/$










Pricing legend
  • $ = 0 - $50
  • $$ = $51 - $100
  • $$$ = $101 - $150
  • $$$$ = > $150
  • Pricing based on one month of therapy at standard dosing in an adult
  • Pricing based on information from GoodRX.com®
  • Pricing may vary by region and availability