ANGIOTENSIN II RECEPTOR BLOCKER (ARB) DOSING









Azilsartan (Edarbi®)

Dosage forms

Tablet
  • 40 mg
  • 80 mg

Dosing

Hypertension
  • Starting: 80 mg once daily
  • Maintenance: 40 - 80 mg once daily
  • Max: 80 mg once daily
  • May take without regard to food

Generic / Price

- NO/$$$$

Other

  • Consider starting dose of 40 mg a day if on high doses of diuretics

Candesartan (Atacand®)

Dosage forms

Tablet
  • 4 mg
  • 8 mg
  • 16 mg
  • 32 mg

Dosing - Adults

Hypertension
  • Starting: 16 mg once daily
  • Maintenance: 8 - 32 mg/day
  • Max: 32 mg/day
  • May be given in one or two divided doses
  • May take without regard to food
Heart failure
  • Starting: 4 mg once daily
  • Target dose: 32 mg once daily
  • Max: 32 once daily
  • Dose may be doubled every 2 weeks as tolerated
  • May take without regard to food

Dosing - Pediatric

Hypertension (1 to 5 years)
  • Starting: 0.20 mg/kg/day
  • Maintenance: 0.05 to 0.4 mg/kg/day
  • May be given in one or two divided doses
  • See Atacand PI [sec 2.2] for instructions on compounding a 1 mg/ml suspension
  • May take without regard to food
Hypertension (6 to 16 years)
  • Starting (< 50 kg): 4 - 8 mg/day
  • Starting (≥ 50 kg): 8 - 16 mg/day
  • Maintenance (< 50 kg): 2 - 16 mg/day
  • Maintenance (≥ 50 kg): 4 - 32 mg/day
  • May be given in one or two divided doses
  • May take without regard to food

Generic / Price

- YES/$

Other

  • In moderate liver disease, starting dose is 8 mg for hypertension
  • Lower starting dose may be appropriate in patients taking diuretics
  • Most of the blood pressure effect is seen within 2 weeks
  • Maximum blood pressure effect is seen within 4 - 6 weeks
  • See Atacand PI [sec 2.2] for instructions on compounding a 1 mg/ml suspension

Eprosartan (Teveten®)

Dosage forms

Tablet
  • 400 mg
  • 600 mg

Dosing

Hypertension
  • Starting: 600 mg once daily
  • Maintenance: 400 - 800 mg/day
  • Max: 800 mg/day
  • May be given in one or two divided doses
  • May take without regard to food

Generic / Price

- YES/$$

Other

  • Moderate-to-severe kidney disease - dose should not exceed 600 mg a day
  • Lower starting dose may be appropriate in patients taking diuretics
  • Maximum blood pressure effect is seen within 2 - 3 weeks

Irbesartan (Avapro®)

Dosage forms

Tablet
  • 75 mg
  • 150 mg
  • 300 mg

Dosing - Adults

Hypertension
  • Starting: 150 mg once daily
  • Maintenance: 150 - 300 mg once daily
  • Max: 300 mg once daily
  • May take without regard to food
Diabetic nephropathy
  • Target dose: 300 mg once daily
  • May take without regard to food

Dosing - Pediatric

Hypertension (6 - 12 years)
  • Starting: 75 mg once daily
  • Max: 150 mg once daily
  • May take without regard to food
  • AAP recommended dosing [2]
Hypertension (≥ 13 years)
  • Starting: 150 mg once daily
  • Max: 300 mg once daily
  • May take without regard to food
  • AAP recommended dosing [2]

Generic / Price

- YES/$

Other

  • Lower starting dose may be appropriate in patients taking diuretics

Losartan (Cozaar®)

Dosage forms

Tablet
  • 25 mg
  • 50 mg
  • 100 mg

Dosing - Adults

Hypertension
  • Starting: 50 mg once daily
  • Maintenance: 25 - 100 mg once daily
  • Max: 100 mg once daily
  • May take without regard to food
Diabetic nephropathy
  • Starting: 50 mg once daily
  • Maintenance: 50 - 100 mg once daily
  • Max: 100 mg once daily
  • May take without regard to food
Hypertension with Left Ventricular Hypertrophy
  • Starting: 50 mg once daily
  • Maintenance: 50 - 100 mg once daily
  • Max: 100 mg once daily
  • May take without regard to food

Dosing - Pediatric

Hypertension (≥ 6 years)
  • Starting: 0.7 mg/kg (max 50 mg) once daily
  • Max: 1.4 mg/kg (max 100 mg) once daily
  • See Cozaar PI [sec 2.5] for instructions on compounding a 2.5 mg/ml suspension
  • May take without regard to food

Generic / Price

- YES/$

Other

  • Lower starting dose may be appropriate in patients taking diuretics
  • Liver disease - starting dose should be 25 mg
  • May take 3 - 6 weeks for maximum effect
  • See Cozaar PI [sec 2.5] for instructions on compounding a 2.5 mg/ml suspension

Olmesartan (Benicar®)

Dosage forms

Tablet
  • 5 mg
  • 20 mg
  • 40 mg

Dosing - Adults

Hypertension
  • Starting: 20 mg once daily
  • Maintenance: 20 - 40 mg once daily
  • Max: 40 mg once daily
  • May take without regard to food

Dosing - Pediatric

Hypertension (6 - 16 years)
  • Starting (20 to <35 kg): 10 mg once daily
  • Starting (≥ 35 kg): 20 mg once daily
  • Max (< 35 kg): 20 mg once daily
  • Max (≥ 35 kg): 40 mg once daily
  • Increase dose at intervals of 2 weeks
  • See Benicar PI [sec 2.2] for instructions on compounding a 2 mg/ml suspension
  • May take without regard to food

Generic / Price

- YES/$-$$

Other

  • Lower starting dose may be appropriate in patients taking diuretics
  • See Benicar PI [sec 2.2] for instructions on compounding a 2 mg/ml suspension

Telmisartan (Micardis®)

Dosage forms

Tablet
  • 20 mg
  • 40 mg
  • 80 mg

Dosing

Hypertension
  • Starting: 40 mg once daily
  • Maintenance: 20 - 80 mg once daily
  • Max: 80 mg once daily
  • May take without regard to food
Cardiovascular risk reduction
  • Target: 80 mg once daily
  • Max: 80 mg once daily
  • May take without regard to food

Generic / Price

- YES/$

Other

  • Lower starting dose may be appropriate in patients taking diuretics
  • Maximum blood pressure effect seen within 4 weeks

Valsartan (Diovan®)

Dosage forms

Tablet
  • 40 mg
  • 80 mg
  • 160 mg
  • 320 mg

Dosing - Adults

Hypertension
  • Starting: 80 - 160 mg once daily
  • Maintenance: 80 - 320 mg once daily
  • Max: 320 mg once daily
  • May take without regard to food
Heart failure
  • Starting: 40 mg twice daily
  • Maintenance: 80 - 160 mg twice daily
  • Max: 160 mg twice daily
  • May take without regard to food
Post-Myocardial infarction
  • Starting: 20 mg twice daily
  • Maintenance: 40 - 160 mg twice daily
  • Max: 160 mg twice daily
  • May take without regard to food

Dosing - Pediatric

Hypertension (6 - 16 years)
  • Starting: 1.3 mg/kg (max 40 mg) once daily
  • Max: 2.7 mg/kg (max 160 mg) once daily
  • See Diovan PI [sec 2.2] for instructions on compounding a 4 mg/ml suspension
  • May take without regard to food

Generic / Price

- YES/$

Other

  • Lower starting dose may be appropriate in patients taking diuretics
  • Maximum blood pressure effect seen within 4 weeks
  • When the suspension is replaced by a tablet, the dose of valsartan may have to be increased. The exposure to valsartan with the suspension is 1.6 times greater than with the tablet.
  • See Diovan PI [sec 2.2] for instructions on compounding a 4 mg/ml suspension



Atacand HCT® (candesartan + HCTZ)

Dosage forms

Tablet
  • Candesartan - HCTZ
    • 16 mg - 12.5 mg
    • 32 mg - 12.5 mg
    • 32 mg - 25 mg

Dosing

Hypertension
  • Dosing: HCTZ 12.5 - 50 mg/day | Candesartan 8 - 32 mg/day
  • May be given once daily or divided into two doses
  • May take without regard to food

Generic / Price

- YES/$-$$

Other

  • Maximal effect seen within 4 weeks

Avalide® (irbesartan + HCTZ)

Dosage forms

Tablet
  • Irbesartan - HCTZ
    • 150 mg - 12.5 mg
    • 300 mg - 12.5 mg

Dosing

Hypertension
  • Starting: 150/12.5 mg once daily
  • Max: 300/25 mg once daily
  • Titrate dose at intervals of 1 - 2 weeks
  • May take without regard to food

Generic / Price

- YES/$

Benicar HCT® (olmesartan + HCTZ)

Dosage forms

Tablet
  • Olmesartan - HCTZ
    • 20 mg - 12.5 mg
    • 40 mg - 12.5 mg
    • 40 mg - 25 mg

Dosing

Hypertension
  • Starting: 20/12.5 - 40/12.5 mg once daily
  • Max: 40/25 mg once daily
  • May take without regard to food

Generic / Price

- YES/$

Diovan HCT® (valsartan + HCTZ)

Dosage forms

Tablet
  • Valsartan - HCTZ
    • 80 mg - 12.5 mg
    • 160 mg - 12.5 mg
    • 160 mg - 25 mg
    • 320 mg - 12.5 mg
    • 320 mg - 25 mg

Dosing

Hypertension
  • Starting: 160/12.5 mg once daily
  • Max: 320/25 mg once daily
  • Titrate dose at intervals of 1 - 2 weeks
  • May take without regard to food

Generic / Price

- YES/$

Other

  • Maximum effect seen within 2 - 4 weeks

Edarbyclor® (azilsartan + chlorthalidone)

Dosage forms

Tablet
  • Azilsartan - Chlorthalidone
    • 40 mg - 12.5 mg
    • 40 mg - 25 mg

Dosing

Hypertension
  • Starting: 40/12.5 mg once daily
  • Max: 40/25 mg once daily
  • Increase dose if needed after 2 - 4 weeks
  • May take without regard to food

Generic / Price

- NO/$$$$

Other

  • Most of the antihypertensive effect is seen within 1 - 2 weeks

Hyzaar® (losartan + HCTZ)

Dosage forms

Tablet
  • Losartan - HCTZ
    • 50 mg - 12.5 mg
    • 100 mg - 12.5 mg
    • 100 mg - 25 mg

Dosing

Hypertension
  • Starting: 50/12.5 mg once daily
  • Max: 100/25 mg once daily
  • Increase dose at intervals of 3 weeks
  • May take without regard to food
Hypertension with LVH to reduce the risk of stroke
  • Starting: 50/12.5 mg once daily
  • Max: 100/25 mg once daily
  • May take without regard to food

Generic / Price

- YES/$

Micardis HCT® (telmisartan + HCTZ)

Dosage forms

Tablet
  • Telmisartan - HCTZ
    • 40 mg - 12.5 mg
    • 80 mg - 12.5 mg
    • 80 mg - 25 mg
    • Comes in sealed blister pack of 30 tablets

Dosing

Hypertension
  • Starting: 80/12.5 mg once daily
  • Max: 160/25 mg once daily
  • Titrate dose at intervals of 2 - 4 weeks
  • May take without regard to food

Generic / Price

- YES/$

Other

  • Do not remove tablet from blister pack until ready to take



Azor® (amlodipine + olmesartan)

Dosage forms

Tablet
  • Amlodipine - Olmesartan
    • 5 mg - 20 mg
    • 5 mg - 40 mg
    • 10 mg - 20 mg
    • 10 mg - 40 mg

Dosing

Hypertension
  • Starting: 5 mg/20 mg once daily
  • Maintenance: 5 mg/20 mg - 10 mg/40 mg once daily
  • Max: 10 mg/40 mg once daily
  • Titrate dose at intervals of 1 - 2 weeks
  • May take without regard to food

Generic / Price

- YES/$

Exforge® (amlodipine + valsartan)

Dosage forms

Tablet
  • Amlodipine - Valsartan
    • 5 mg - 160 mg
    • 5 mg - 320 mg
    • 10 mg - 160 mg
    • 10 mg - 320 mg

Dosing

Hypertension
  • Starting: 5 mg/160 mg once daily
  • Maintenance: 5 mg/160 mg - 10 mg/320 mg once daily
  • Max: 10 mg/320 mg once daily
  • Full antihypertensive effect typically seen within 2 weeks
  • May take without regard to food

Generic / Price

- YES/$

Twynsta® (amlodipine + telmisartan)

Dosage forms

Tablet
  • Telmisartan - Amlodipine
    • 40 mg - 5 mg
    • 40 mg - 10 mg
    • 80 mg - 5 mg
    • 80 mg - 10 mg

Dosing

Hypertension
  • Starting: 40 mg/5 mg once daily
  • Maintenance: 40 mg/5 mg - 80 mg/10 mg once daily
  • Max: 80 mg/10 mg once daily
  • Most of the antihypertensive effect is typically seen within 2 weeks
  • May take without regard to food

Generic / Price

- YES/$$



Byvalson® (nebivolol + valsartan)

Dosage forms

Tablet
  • Nebivolol - Valsartan
    • 5 mg - 80 mg

Dosing

Hypertension
  • Dosing: 5/80 mg once daily
  • Maximum effect occurs within 2 - 4 weeks
  • Increasing dose does not results in any meaningful further blood pressure reduction
  • May take without regard to food

Generic / Price

- NO/$$$



Exforge HCT® (amlodipine + valsartan + HCTZ)

Dosage forms

Tablet
  • Amlodipine - Valsartan - HCTZ
    • 5 mg - 160 mg - 12.5 mg
    • 5 mg - 160 mg - 25 mg
    • 10 mg - 160 mg - 12.5 mg
    • 10 mg - 160 mg - 25 mg
    • 10 mg - 320 mg - 25 mg

Dosing

Hypertension
  • Starting: 5/160/12.5 once daily
  • Maintenance: 5/160/12.5 mg - 10/320/25 mg once daily
  • Max: 10/320/25 mg once daily
  • Titrate dose at intervals of 2 weeks
  • Full antihypertensive effect is seen after 2 weeks
  • May take without regard to food

Generic / Price

- YES/$$

Tribenzor® (amlodipine + olmesartan + HCTZ)

Dosage forms

Tablet
  • Amlodipine - Olmesartan - HCTZ
    • 5 mg - 20 mg - 12.5 mg
    • 5 mg - 40 mg - 12.5 mg
    • 5 mg - 40 mg - 25 mg
    • 10 mg - 40 mg - 12.5 mg
    • 10 mg - 40 mg - 25 mg

Dosing

Hypertension
  • Starting: 5/20/12.5 mg once daily
  • Maintenance: 5/20/12.5 mg - 10/40/25 mg once daily
  • Max: 10/40/25 mg once daily
  • Titrate dose at intervals of 2 weeks
  • May take without regard to food

Generic / Price

- YES/$$-$$$










Pricing legend
  • $ = 0 - $50
  • $$ = $51 - $100
  • $$$ = $101 - $150
  • $$$$ = > $150
  • Pricing based on one month of therapy at standard dosing in an adult
  • Pricing based on information from GoodRX.com®
  • Pricing may vary by region and availability