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- ANTICHOLINERGIC SIDE EFFECTS
- Mild side effects (more common)
- Constipation
- Dry mouth
- Urinary hesitancy (difficulty starting urination)
- Decreased sweating
- Drowsiness, fatigue
- Difficulty concentrating
- Severe side effects (toxicity)
- Agitation
- Delirium
- Dilated pupils (mydriasis)
- Hot, dry, red skin
- Loss of bowel sounds
- Rapid heart rate
- Urinary retention
- Vision changes
- MEDICATIONS WITH ANTICHOLINERGIC ACTIVITY
- Antiarrhythmics
- Atropine
- Disopyramide (Norpace®)
- Procainamide
- Quinidine
- Antidepressants (tricyclic)
- Amitriptyline (Elavil®)
- Clomipramine (Anafranil®)
- Desipramine (Norpramin®)
- Doxepin (Silenor®)
- Imipramine (Tofranil®)
- Nortriptyline (Pamelor®)
- Antidepressants (other)
- Mirtazapine (Remeron®) - moderate antagonist
- Antidiarrheals
- Diphenoxylate/atropine (Lomotil®)
- Antihistamines
- Cetirizine (Zyrtec®)
- Chlorpheniramine (Chlor-Trimeton®)
- Clemastine (Tavist®)
- Dexchlorpheniramine
- Diphenhydramine (Benadryl®)
- Doxepin (Silenor®)
- Fexofenadine (Allegra®)
- Hydroxyzine (Vistaril®, Atarax®)
- Loratadine (Claritin®)
- Antiparkinson agents
- Benztropine (Cogentin®)
- Biperiden (Akineton®)
- Procyclidine
- Trihexyphenidyl
- Antipsychotics
- Clozapine (Clozaril®)
- Chlorpromazine (Thorazine®)
- Fluphenazine (Prolixin®)
- Haloperidol (Haldol®)
- Olanzapine (Zyprexa®)
- Prochlorperazine (Compazine®)
- Quetiapine (Seroquel®)
- Thioridazine (Mellaril®)
- Thiothixene (Navane®)
- Bladder medications
- Darifenacin (Enablex®)
- Fesoterodine (Toviaz®)
- Oxybutynin (Ditropan®)
- Solifenacin (Vesicare®)
- Tolterodine (Detrol®)
- Trospium (Sanctura®)
- COPD / Asthma medications
- Ipratropium (Atrovent®)
- Formoterol (Foradil®)
- Gastrointestinal antispasmodics
- Dicyclomine (Bentyl®)
- Glycopyrrolate (Robinul®)
- Hyoscyamine (Levsin®)
- Methscopolamine (Pamine®)
- Propantheline
- Muscle relaxers
- Cyclobenzaprine (Flexeril®)
- Orphenadrine (Norflex®)
- Nausea/vertigo medications
- Cyclizine (Cyclivert®)
- Dimenhydrinate (Dramamine®)
- Meclizine (Antivert®, Bonine®)
- Prochlorperazine (Compazine®)
- Promethazine (Phenergan®)
- Scopolamine (hyoscine, Scopoderm®)
- Trimethobenzamide (Tigan®)
- Seizure medications
- Carbamazepine (Tegretol®) - mild anticholinergic effects [2]
- BIBLIOGRAPHY
- 1 - PMID 11089480
- 2 - Manufacturer's PI for various medications