ANTIFUNGAL MEDICATIONS









Terbinafine (Lamisil®)

Dosage forms

Tablet
  • 250 mg ($)
Cream, OTC
  • 1% cream ($)
Spray, OTC
  • 1% spray ($)

Dosing

Pediatric (≥ 2 years)
  • Tinea capitis
    • Terbinafine tablets
    • NOTE: Tablet dosing based on one study [PMID 12195561]
      • Weight 10 - 20 kg: 62.5 mg daily for 4 weeks
      • Weight 20 - 40 kg: 125 mg daily for 4 weeks
      • Weight > 40 kg: 250 mg daily for 4 weeks
    • Terbinafine granules
    • NOTE: Terbinafine granules are FDA-approved for children ≥ 4 years old
      • Weight < 25 kg: 125 mg daily for 6 weeks
      • Weight 25 - 35 kg: 187.5 mg daily for 6 weeks
      • Weight > 35 kg: 250 mg daily for 6 weeks (PI)
  • Tinea corporis, Tinea pedis, Tinea cruris, Tinea manuum
    • Terbinafine tablets
    • NOTE: Tablet dosing based on study in children ≥ 2 years old with tinea capitis [PubMed 12195561]
      • Weight 10 - 20 kg: 62.5 mg daily for 2 - 4 weeks
      • Weight 20 - 40 kg: 125 mg daily for 2 - 4 weeks
      • Weight > 40 kg: 250 mg daily for 2 - 4 weeks ($)
  • Tinea versicolor - topical terbinafine applied twice daily for one week (CTE) NOTE: Oral terbinafine is not effective for tinea versicolor
Adults

Other

  • May take without regard to food
  • Terbinafine granules are FDA-approved in children ≥ 4 years. Terbinafine tablets have been used in children as young as 2 years - (See PubMed 12195561)
  • Terbinafine is a Moderate CYP2D6 inhibitor
  • May cause taste and smell disturbance
  • Manufacturer recommends pretreatment transaminases (AST, ALT). If normal, then recheck if patient develops clinical signs of liver disease (persistent nausea, jaundice, dark urine, abdominal pain, etc.)
  • Kidney disease
    • CrCl ≤ 50 ml/min: clearance decreased by 50%. Manufacturer makes no specific dosage recommendations.



Fluconazole (Diflucan®)

Dosage forms

Tablet
  • 50 mg ($)
  • 100 mg ($)
  • 150 mg ($)
  • 200 mg ($)
Suspension
  • 50 mg/5 ml ($)
  • 200 mg/5 ml ($)

Dosing

Pediatric
Adults

Other

  • May take without regard to food
  • Fluconazole has many drug interactions
  • Fluconazole is a Strong CYP2C9 inhibitor
  • Fluconazole is a Moderate CYP3A4 inhibitor
  • Kidney disease
    • CrCl ≤ 50 ml/min - give half of recommended dose
    • Regular dialysis - give full dose after each dialysis; on non-dialysis days give half recommended dose

Studies


Itraconazole (Sporanox®)

Dosage forms

Capsule
  • 100 mg ($$)
Capsule (Tolsura®)
  • 65 mg ($$$$)
Tablet (Onmel®)
  • 200 mg ($$$$)
Solution
  • 10 mg/ml ($$$)

Dosing

Pediatric (infants)
Pediatric (≥ 1 year)
  • Tinea capitis
    • 5 mg/kg once daily for 2 - 4 weeks
    • Alternative:
      • Weight < 20 kg: 50 mg once daily for 4 weeks
      • Weight > 20 kg: 100 mg once daily for 4 weeks
      • Based on PMID 11069511
Adults
Adults (Tolsura®)
  • NOTE: Tolsura is not interchangeable or substitutable with other itraconazole products due to differences in dosing
  • Blastomycosis and Histoplasmosis - 130 mg once daily. If no obvious improvement, or there is evidence of progressive fungal disease, the dose should be increased in 65 mg increments to a maximum of 130 mg twice daily. Doses above 130 mg/day should be given in two divided doses.
  • Aspergillosis - 130 mg once daily. Increase to 130 mg twice daily if necessary.
  • NOTE: Tolsura is not indicated for the treatment of onychomycosis

Other

  • Take with a full meal
  • Itraconazole is contraindicated in patients with heart failure because of negative inotropic effects
  • Itraconazole has many drug interactions. See Sporanox PI for more.
  • Itraconazole is a Strong CYP3A4 inhibitor
  • Itraconazole is a P-glycoprotein inhibitor
  • Kidney disease - Use caution. Manufacturer makes no specific recommendation.



Griseofulvin | Grifulvin V® | Gris-Peg®

Griseofulvin microsize

Tablet (Grifulvin V®)
  • 250 mg (?)
  • 500 mg ($$)
Suspension
  • 125 mg/5 ml (240 ml $-$$)

Griseofulvin ultramicrosize

Tablet (Gris-Peg®)
  • 125 mg ($-$$)
  • 250 mg ($$)

Dosing

Pediatric (Infants)
  • Tinea capitis
    • Griseofulvin microsize
      • 15 mg/kg once daily for 45 - 60 days
    • Griseofulvin ultramicrosize
      • 10 mg/kg once daily for 30 - 60 days
Pediatric
  • Tinea capitis
    • Griseofulvin microsize
      • 20 - 25 mg/kg once daily for 6 - 8 weeks (CTE)
    • Griseofulvin ultramicrosize
      • 10 - 15 mg/kg once daily for 6 - 8 weeks (CTE)
  • Tinea corporis
    • Griseofulvin microsize
      • 10 mg/kg once daily (max 500 mg/day) for 2 - 4 weeks (PI)
    • Griseofulvin ultramicrosize
      • 7.25 mg/kg once daily (max 375 mg/day) for 2 - 4 weeks (PI)
  • Tinea pedis
    • Griseofulvin microsize
      • 10 mg/kg once daily (max 500 mg/day) for 4 - 8 weeks (PI)
    • Griseofulvin ultramicrosize
      • 7.25 mg/kg once daily (max 375 mg/day) for 4 - 8 weeks (PI)
Adults
  • Tinea capitis
    • Griseofulvin microsize
      • 500 mg once daily for 6 - 8 weeks (CTE)
    • Griseofulvin ultramicrosize
      • 375 mg once daily for 6 - 8 weeks (CTE)
  • Tinea corporis
    • Griseofulvin microsize
      • 500 mg once daily for 2 - 4 weeks (PI)
    • Griseofulvin ultramicrosize
      • 375 mg once daily for 2 - 4 weeks (PI)
  • Tinea pedis
    • Griseofulvin microsize
      • 500 mg once daily for 4 - 8 weeks (PI)
    • Griseofulvin ultramicrosize
      • 375 mg twice daily for 4 - 8 weeks (PI)
  • Onychomycosis - toenails
    • Griseofulvin microsize
      • 500 mg once daily for 6 months (PI)
    • Griseofulvin ultramicrosize
      • 375 mg twice daily for 6 months (PI)
  • Onychomycosis - fingernails
    • Griseofulvin microsize
      • 500 mg once daily for 4 months (PI)
    • Griseofulvin ultramicrosize
      • 375 mg twice daily for 4 months (PI)

Other

  • May take without regard to food
  • Gastrointestinal upset is common
  • May cause photosensitivity. Limit sun exposure, use sunscreen.
  • Lab monitoring (CBC, ALT, AST) during griseofulvin treatment does not appear to be necessary during shorter courses of therapy (≤ 8 weeks) in healthy patients
  • Kidney disease - manufacturer makes no specific dosage recommendations



Pricing legend
  • $ = 0 - $50
  • $$ = $51 - $100
  • $$$ = $101 - $150
  • $$$$ = > $151
  • Pricing based on one month of therapy at standard dosing in an adult
  • Pricing based on information from GoodRX.com®
  • Pricing may vary by region and availability