APROCITENTAN (TRYVIO®)





Acronyms



MECHANISM OF ACTION



FDA-APPROVED INDICATIONS



RESISTANT HYPERTENSION


  • All patients were receiving amlodipine, valsartan, and HCTZ at baseline
  • BPs are unattended automated office BPs
  • Reference [1]
Effects of Aprocitentan on BP in a 4-week trial
Aprocitentan 12.5 mg once daily
(N=243)
Placebo
(N=244)
Baseline BP 153/88 153/87
SBP change -15.4 -11.6
DBP change -10.4 -6.4


SIDE EFFECTS







CONTRAINDICATIONS



PRECAUTIONS







DRUG INTERACTIONS




DOSING




LONG-TERM SAFETY



BIBLIOGRAPHY