• Recommended dose is 81 mg once daily
  • *B - there is high certainty that the net benefit is moderate or there is moderate certainty that the net benefit is moderate to substantial; C - there is at least moderate certainty that the net benefit is small; I - insufficient evidence to recommend for or against
  • Increased risk of bleeding defined as dose of aspirin used, history of GI ulcers or upper GI pain, bleeding disorders, renal failure, severe liver disease, and thrombocytopenia. Other factors that increase risk include concurrent anticoagulation therapy or NSAID use, uncontrolled hypertension, male sex, and older age.
  • Reference USPSTF website
Aspirin for the primary prevention of cardiovascular disease and colorectal cancer
Age Recommendation
50 - 59 years Low-dose aspirin is recommended in patients who meet the following criteria:
  • 10-year risk of CVD of ≥ 10% (based on AHA risk calculator)
  • Not at increased risk of bleeding
  • Life expectancy of at least 10 years
  • Willing to take low-dose aspirin for at least 10 years
  • Grade B*
60 - 69 years
  • Decision should be individualized
  • Criteria for 50 - 59 year olds should be met
  • Grade C*
< 50 years or ≥ 70 years
  • Insufficient evidence to make recommendation
  • Grade I*