BILE ACID SEQUESTRANT DOSING









Cholestyramine (Questran®)

Dosage forms

Questran® powder
  • 4 grams of cholestyramine resin per 9 grams of powder
  • 378 gram can (42 doses)
  • 9 gram packet (carton of 60)
Cholestyramine powder
  • 4 grams of cholestyramine resin per 8.78 grams of powder
  • 368.76 gram can (42 doses)
  • 8.78 gram packet (carton of 60)
Cholestyramine powder
  • 4 grams of cholestyramine resin per 8.3 grams of powder
  • 348.6 gram can (42 doses)
  • 8.3 gram packet (carton of 60)

Dosing

High cholesterol / Pruritus
  • Starting: 4 grams of cholestyramine resin 1 - 2 times daily
  • Maintenance: 8 - 16 grams of cholestyramine resin a day given in 2 divided doses
  • Max: 24 grams of cholestyramine resin per day
  • Increase dose at intervals of 1 week
  • May be administered in 1 - 6 doses per day
  • Best to take with meals, but may be taken at other times

Generic / Price

  • Can - YES/$
  • Packets (#60) - YES/$-$$

Other

  • Mix with 2 - 6 oz of water or beverage
  • May also be mixed with applesauce or crushed pineapple
  • Color of powder may vary from batch to batch

Cholestyramine light | Questran Light® | Prevalite®

Dosage forms

Questran® Light powder
  • 4 grams of cholestyramine resin per 5 grams of powder
  • 210 gram can (42 doses)
  • 5 gram packets (carton of 60)
Prevalite® powder
  • 4 grams of cholestyramine resin per 5.5 grams of powder
  • 231 gram can (42 doses)
  • 5.5 gram packets (carton of 42 or 60)
Cholestyramine light powder
  • 4 grams of cholestyramine resin per 4.8 grams of powder
  • 201.6 gram can (42 doses)
  • 4.8 gram packets (carton of 60)
Cholestyramine light powder
  • 4 grams of cholestyramine resin per 5.7 grams of powder
  • 239.4 gram can (42 doses)
  • 4.8 gram packets (carton of 60)

Dosing

High cholesterol / Pruritus
  • Starting: 4 grams of cholestyramine resin 1 - 2 times daily
  • Maintenance: 8 - 16 grams of cholestyramine resin a day given in 2 divided doses
  • Max: 24 grams of cholestyramine resin per day
  • Increase dose at intervals of 1 week
  • May be administered in 1 - 6 doses per day
  • Best to take with meals, but may be taken at other times

Generic / Price

  • Can - YES/$
  • Packets (#60) - YES/$

Other

  • Mix with 2 - 6 oz of water or beverage
  • May also be mixed with applesauce or crushed pineapple
  • Color of powder may vary from batch to batch

Colesevelam tablet (Welchol™)

Dosage forms

Tablet
  • 625 mg
Powder for oral suspension
  • 3.75 gram packet
  • Comes in carton of 30

Dosing

Type 2 diabetes in adults / Hyperlipidemia in adults and boys and postmenarchal girls aged 10 to 17 years
  • Tablets
    • Dosing: 6 tablets once daily or 3 tablets twice a day
    • Max: 6 tablets a day
    • Take with a meal and liquid
  • Powder
    • Dosing: one packet (3.75 grams) once daily
    • Max: one packet (3.75 grams) once daily
    • Empty one packet into a glass or cup. Add 1 cup (8 ounces) of water, fruit juice, or diet soft drinks. Stir well and drink.
    • Take with meals

Other

  • Colesevelam can be dosed at the same time as a statin, or colesevelam and the statin can be dosed apart
  • Monitor lipid levels within 4 to 6 weeks after initiation of colesevelam

Generic / Price

  • Tablet (#180) - YES/$$
  • Powder (#30) - NO/$$$$

Colestipol tablet (Colestid®)

Dosage forms

Tablet
  • 1 gram

Dosing

High cholesterol
  • Starting: 2 grams once or twice daily
  • Maintenance: 2 - 16 grams a day given in one or two divided doses
  • Max: 16 grams of colestipol per day
  • Increase dose in increments of 2 - 4 grams a day at intervals of 1 - 2 months
  • Best to take with meals, but may be taken at other times

Generic / Price

- YES/$ (60 tablets)

Other

  • Do not crush, cut, or chew tablets

Colestipol granules (Colestid®)

Dosage forms

Granules
  • Each packet or teaspoon contains 5 grams of colestipol
  • Comes in cartons of 30 or 90 packets
  • Comes in bottles of 300 grams and 500 grams
Flavored Granules
  • 7.5 grams of flavored granules contains 5 grams of colestipol
  • Comes in carton of 60 packets
  • Comes in bottle of 450 grams

Dosing

High cholesterol
  • Starting: 5 grams of colestipol once or twice daily
  • Maintenance: 5 - 30 grams of colestipol a day given 1 or 2 divided doses
  • Max: 30 grams of colestipol per day
  • Increase dose in increments of 5 grams a day at intervals of 1 - 2 months
  • Best to take with meals, but may be taken at other times

Generic / Price

- YES/$ (30 packets)

Other

  • Mix with ≥ 3 oz of liquid of choice
  • May also be mixed with cereals, soups, and fruits










Pricing legend
  • $ = 0 - $50
  • $$ = $51 - $100
  • $$$ = $101 - $150
  • $$$$ = > $151
  • Pricing based on one month of therapy at standard dosing in an adult
  • Pricing based on information from GoodRX.com®
  • Pricing may vary by region and availability