CALCIUM CHANNEL BLOCKER DOSING









Amlodipine | Norvasc® | Katerzia® | Norliqva®

Dosage forms

Tablet (Norvasc®)
  • 2.5 mg
  • 5 mg
  • 10 mg
Suspension (Katerzia®)
  • 1 mg/ml
  • Comes in 150 ml bottle
  • Keep refrigerated
Solution (Norliqva®)
  • 1 mg/ml
  • Comes in 150 ml bottle
  • Store at room temp

Dosing

Hypertension (adults)
  • Starting: 5 mg once daily
  • Maintenance: 5 - 10 mg once daily
  • Max: 10 mg once daily
  • Increase dose at intervals of 7 - 14 days
  • Consider starting dose of 2.5 mg in patients who are small, fragile, elderly, or have hepatic insufficiency
  • May take without regard to food
Hypertension (6 - 17 years)
  • Dosing: 2.5 - 5 mg once daily
  • Max: 5 mg once daily
  • May take without regard to food
Hypertension (1 - 5 years)
  • Starting: 0.1 mg/kg once daily
  • Max: 0.6 mg/kg (max 5 mg) once daily
  • AAP recommended dosing [2]
  • May take without regard to food
Stable and vasospastic angina (adults)
  • Dosing: 5 - 10 mg once daily
  • Most patients will require 10 mg once daily
  • May take without regard to food
Kidney disease
  • No dose adjustment necessary in kidney disease
Liver disease (adults)
  • Amlodipine is extensively metabolized by the liver and the plasma elimination half-life is 56 hours in patients with impaired hepatic function. Use a starting dose of 2.5 mg once daily and titrate slowly.

Generic / Price

  • Tablet - YES/$
  • Suspension (Katerzia) - NO/$$$$
  • Solution (Norliqva) - NO/$$$$

Diltiazem IR (Cardizem®)

Dosage forms

Tablet
  • 30 mg
  • 60 mg
  • 90 mg
  • 120 mg

Dosing

Stable and vasospastic angina (adults)
  • Starting: 30 mg four times a day
  • Maintenance: 180 - 360 mg a day
  • Max: 360 mg a day
  • Give in 3 - 4 divided doses
  • Increase dose at 1 - 2 day intervals
  • Take before meals and at bedtime
Kidney disease
  • Diltiazem is excreted by the kidneys. Start low and titrate slowly.
  • A single study in 9 patients with severe kidney disease showed no difference in diltiazem pharmacokinetics compared to those with normal function.
Liver disease
  • Diltiazem should be used with caution in patients with significant liver disease
  • In a study of patients with cirrhosis, diltiazem's half-life was increased, and there was a 69% increase in AUC compared to patients with normal liver function.

Generic / Price

- YES/$

Diltiazem ER | Cardizem® CD | Cartia XT®

Dosage forms

Capsule, extended-release
  • 120 mg
  • 180 mg
  • 240 mg
  • 300 mg
  • 360 mg

Dosing

Hypertension (adults)
  • Starting: 180 - 240 mg once daily
  • Maintenance: 240 - 360 mg once daily
  • Max: 480 mg once daily
  • Increase dose at intervals of 14 days
  • When switching from diltiazem IR, use nearest equivalent total daily dosage
  • May take without regard to food
Angina (stable and vasospastic)
  • Starting: 120 - 180 mg once daily
  • Maintenance: titrate to response
  • Maximum: 480 mg once daily
  • Titrate dose over 7 - 14 days
  • When switching from diltiazem IR, use nearest equivalent total daily dosage
  • May take without regard to food
Kidney disease
  • Diltiazem is excreted by the kidneys. Start low and titrate slowly.
  • A single study in 9 patients with severe kidney disease showed no difference in diltiazem pharmacokinetics compared to those with normal function.
Liver disease
  • Diltiazem should be used with caution in patients with significant liver disease
  • In a study of patients with cirrhosis, diltiazem's half-life was increased, and there was a 69% increase in AUC compared to patients with normal liver function

Generic / Price

- YES/$

Diltiazem ER (Cardizem® LA)

Dosage forms

Tablet, extended-release
  • 120 mg
  • 180 mg
  • 240 mg
  • 300 mg
  • 360 mg
  • 420 mg

Dosing

Hypertension (adults)
  • Starting: 180 - 240 mg once daily
  • Maintenance: 240 - 360 mg once daily
  • Max: 540 mg once daily
  • Increase dose at intervals of 14 days
  • When switching from diltiazem IR, use nearest equivalent total daily dosage
  • Do not crush, cut, or chew tablet
  • May take without regard to food
Angina (stable and vasospastic)
  • Starting: 180 mg once daily
  • Maintenance: 180 - 360 mg once daily
  • Max: 360 mg once daily
  • Titrate dose over 7 - 14 days
  • When switching from diltiazem IR, use nearest equivalent total daily dosage
  • Do not crush, cut, or chew tablet
  • May take without regard to food
Kidney disease
  • No dose adjustment is necessary
Liver disease
  • Child Pugh A and B: no dose adjustment is likely to be needed
  • Child Pugh C: manufacturer makes no recommendation. In a study of patients with cirrhosis, diltiazem's half-life was increased, and there was a 69% increase in AUC compared to patients with normal liver function.

Generic / Price

- YES/$

Diltiazem ER (Dilacor XR®)

Dosage forms

Capsule, extended-release
  • 120 mg
  • 180 mg
  • 240 mg

Dosing

Hypertension (adults)
  • Starting: 180 - 240 mg once daily
  • Maintenance: 180 - 480 mg once daily
  • Max: 540 mg once daily
  • Increase dose at intervals of 14 days
  • When switching from diltiazem IR, use nearest equivalent total daily dosage
  • Do not open, chew, or crush capsules
  • Take on an empty stomach. High-fat meal increases absorption.
Angina (stable and vasospastic)
  • Starting: 120 once daily
  • Maintenance: titrate to response
  • Maximum: 480 mg once daily
  • Titrate dose over 7 - 14 days
  • When switching from diltiazem IR, use nearest equivalent total daily dosage
  • Do not open, chew, or crush capsules
  • Take on an empty stomach. High-fat meal increases absorption.
Kidney disease
  • Patients with severely impaired renal function showed no difference in the pharmacokinetic profile of diltiazem compared to patients with normal renal function
Liver disease
  • Diltiazem should be used with caution in patients with significant liver disease
  • In a study of patients with cirrhosis, diltiazem's half-life was increased, and there was a 69% increase in AUC compared to patients with normal liver function.

Generic / Price

- YES/$

Diltiazem ER | Taztia XT® | Tiazac®

Dosage forms

Capsule, extended-release
  • 120 mg
  • 180 mg
  • 240 mg
  • 300 mg
  • 360 mg
  • 420 mg

Dosing

Hypertension (adults)
  • Starting: 120 - 240 mg once daily
  • Maintenance: 120 - 540 mg once daily
  • Max: 540 mg once daily
  • Increase dose at intervals of 14 days
  • Capsules may be opened and sprinkled on applesauce. Applesauce should be swallowed immediately without chewing, and followed with a glass of water.
  • May take without regard to food
Angina (stable and vasospastic)
  • Starting: 120 - 180 mg once daily
  • Maintenance: titrate to response
  • Maximum: 540 mg once daily
  • Titrate dose over 7 - 14 days
  • Capsules may be opened and sprinkled on applesauce. Applesauce should be swallowed immediately without chewing, and followed with a glass of water.
  • May take without regard to food
Kidney disease
  • Use caution. Patients with severely impaired renal function (creatinine clearance < 50 mL/min) who received immediate-release diltiazem had modestly increased diltiazem concentrations compared to patients with normal renal function
Liver disease
  • Use caution. In a study of patients with cirrhosis, diltiazem's half-life was increased, and there was a 69% increase in AUC compared to patients with normal liver function.

Generic / Price

- YES/$

Felodipine (Plendil®)

Dosage forms

Tablet, extended-release
  • 2.5 mg
  • 5 mg
  • 10 mg

Dosing

Hypertension (adults)
  • Starting: 5 mg once daily
  • Maintenance: 2.5 - 10 mg once daily
  • Max: 10 mg once daily
  • Consider starting dose of 2.5 mg in elderly patients and patients with liver disease
  • Do not crush, cut, or chew tablet
  • Take without food or with a light meal
Hypertension (≥ 6 years old)
  • Starting: 2.5 once daily
  • Max: 10 mg once daily
  • Do not crush, cut, or chew tablet
  • Take without food or with a light meal
  • AAP recommended dosing [2]
Kidney disease
  • No dose adjustment necessary
Liver disease
  • Clearance is reduced by about 60%. Starting dose should be 2.5 mg and blood pressure should be monitored closely while titrating.

Generic / Price

- YES/$

Isradipine (Dynacirc®)

Dosage forms

Capsule
  • 2.5 mg
  • 5 mg

Dosing

Hypertension
  • Starting: 2.5 mg twice a day
  • Maintenance: 2.5 - 10 mg twice a day
  • Max: 10 mg twice a day
  • Increase dose in increments of 5 mg/day at 2 - 4 week intervals
  • Maximum response seen in 2 - 4 weeks
  • May take without regard to food. Food slows absorption but does not affect the extent of absorption.
Kidney disease
  • Mild renal impairment (creatinine clearance 30 - 80 mL/min) increases the AUC of isradipine by 45%. Progressive deterioration reverses this trend, and patients with severe renal failure (creatinine clearance < 10 mL/min) who have been on hemodialysis show a 20% - 50% lower AUC than healthy volunteers. Starting dose of 2.5 mg twice a day is recommended in mild renal impairment.
Liver disease
  • In patients with hepatic impairment, AUC is increased by 52%. Recommended starting dose is 2.5 mg twice a day.

Generic / Price

- YES/$

Nicardipine (Cardene®)

Dosage forms

Capsule
  • 20 mg
  • 30 mg

Dosing

Hypertension (adults)
  • Starting: 20 mg three times a day
  • Maintenance: 20 - 40 mg three times a day
  • Increase dose at intervals of ≥ 3 days
  • May take without regard to food
Angina (stable and vasospastic)
  • Starting: 20 mg three times a day
  • Maintenance: 20 - 40 mg three times a day
  • Increase dose at intervals of ≥ 3 days
  • May take without regard to food
Kidney disease
  • Exposure is increased. Start with 20 mg three times a day and titrate slowly.
Liver disease
  • Exposure is increased. Use caution. In severe liver disease, start with 20 mg twice a day and titrate slowly while maintaining twice daily dosing.

Generic / Price

- YES/$$$$

Nifedipine IR (Procardia®)

Dosage forms

Capsule
  • 10 mg
  • 20 mg

Dosing

Angina (stable and vasospastic)
  • Starting: 10 mg three times a day
  • Maintenance: 10 - 20 mg three times a day
  • Max: 180 mg a day
  • In some patients, 20 - 30 mg three to four times a day may be necessary
  • Titrate dose over 7 - 14 days
  • Swallow capsule whole
  • May take without regard to food. Do not take with grapefruit juice.
Kidney disease
  • Has not been studied. Use caution.
Liver disease
  • Exposure is increased. Use caution.

Generic / Price

- YES/$

Nifedipine ER | Adalat® CC | Afeditab® CR

Dosage forms

Tablet, extended-release
  • 30 mg
  • 60 mg
  • 90 mg

Dosing

Hypertension (adults)
  • Starting: 30 mg once daily
  • Maintenance: 30 - 60 mg once daily
  • Max: 90 mg once daily
  • Titrate dose over 7 - 14 days
  • Do not cut, crush, or divide tablet
  • Take on an empty stomach. Do not take with grapefruit juice.
Hypertension (children)
  • Starting: 0.2 - 0.5 mg/kg/day
  • Max: 3 mg/kg/day (max 120 mg/day)
  • May be given once daily or in 2 divided doses
  • Do not cut, crush, or divide tablet
  • Take on an empty stomach. Do not take with grapefruit juice.
  • AAP recommended dosing [2]
Kidney disease
  • Has not been studied. Use caution.
Liver disease
  • Exposure is increased. Use caution.

Generic / Price

- YES/$

Nifedipine ER (Procardia XL®)

Dosage forms

Tablet, extended-release
  • 30 mg
  • 60 mg
  • 90 mg

Dosing

Hypertension (adults)
  • Starting: 30 - 60 mg once daily
  • Maintenance: 30 - 120 mg once daily
  • Max: 120 mg once daily
  • Titrate dose over 7 - 14 days
  • Do not cut, crush, or divide tablet. Swallow whole.
  • May take without regard to food. Do not take with grapefruit juice.
Hypertension (children)
  • Starting: 0.2 - 0.5 mg/kg/day
  • Max: 3 mg/kg/day (max 120 mg/day)
  • May be given once daily or in 2 divided doses
  • Do not cut, crush, or divide tablet. Swallow whole.
  • May take without regard to food. Do not take with grapefruit juice.
  • AAP recommended dosing [2]
Angina (stable and vasospastic)
  • Starting: 30 - 60 mg once daily
  • Maintenance: 30 - 90 mg once daily
  • Max: 90 mg once daily
  • Titrate dose over 7 - 14 days
  • Do not cut, crush, or divide tablet. Swallow whole.
  • May take without regard to food. Do not take with grapefruit juice.
Kidney disease
  • Has not been studied. Use caution.
Liver disease
  • Exposure is increased. Use caution.

Generic / Price

- YES/$

Nisoldipine ER (Sular®)

Dosage forms

Tablet, extended-release
  • 8.5 mg
  • 17 mg
  • 20 mg
  • 25.5 mg
  • 30 mg
  • 34 mg
  • 40 mg

Dosing

Hypertension (adults)
  • Starting: 17 - 20 mg once daily
  • Maintenance: 17 - 40 mg once daily
  • Max: 40 mg once daily
  • Increase dose at intervals of ≥ 1 week
  • Do not cut, crush, or divide tablet. Swallow whole.
  • Take on an empty stomach (1 hr before or 2 hrs after a meal). Do not take with grapefruit juice
Kidney disease
  • Dose adjustments in mild to moderate renal impairment are not necessary
Liver disease
  • Exposure is increased. Use a starting dose of 8.5 mg and titrate slowly.

Generic / Price

- YES/$$-$$$$ depending on dose

Verapamil IR (Calan®)

Dosage forms

Tablet
  • 40 mg
  • 80 mg
  • 120 mg

Dosing

Hypertension (adults)
  • Starting: 80 mg three times a day
  • Maintenance: 80 - 120 mg three times a day
  • Max: 360 mg a day
  • Blood pressure effect seen within first week of therapy
  • Consider starting dose of 40 mg three times a day in elderly and small patients
  • May take without regard to food
Angina (stable and vasospastic)
  • Dosing: 80 - 120 mg three times a day
  • Increase dose at daily or weekly intervals depending on response
  • Consider starting dose of 40 mg three times a day in elderly and small patients
  • May take without regard to food
Supraventricular arrhythmias
  • Dosing: 240 - 480 mg a day
  • Max: 480 mg a day
  • Give in 3 or 4 divided doses
  • Maximum effects are seen within the first 48 hours
  • May take without regard to food
Kidney disease
  • About 70% of verapamil dose is excreted by the kidneys. Use caution in patients with impaired renal function and monitor for abnormal prolongation of the PR interval.
Liver disease
  • Exposure is increased. For patients with severe liver disease, the dose of verapamil should be about 30% of the dose given to patients with normal liver function.

Generic / Price

- YES/$

Verapamil ER (Calan® SR)

Dosage forms

Tablet, extended-release
  • 120 mg
  • 180 mg
  • 240 mg

Dosing

Hypertension
  • Starting: 180 mg once daily
  • Maintenance: 180 - 480 mg a day
  • Max: 480 mg a day
  • Daily doses > 240 mg should be given in 2 divided doses
  • Consider starting dose of 120 mg once daily in elderly and small patients
  • Blood pressure effect seen within first week of therapy
  • Take with food
Kidney disease
  • About 70% of verapamil dose is excreted by the kidneys. Use caution in patients with impaired renal function and monitor for abnormal prolongation of the PR interval.
Liver disease
  • Exposure is increased. For patients with severe liver disease, the dose of verapamil should be about 30% of the dose given to patients with normal liver function.

Generic / Price

- YES/$

Verapamil ER (Verelan®)

Dosage forms

Capsule, extended-release
  • 120 mg
  • 180 mg
  • 240 mg
  • 360 mg

Dosing

Hypertension
  • Starting: 240 mg once daily
  • Maintenance: 240 - 480 mg once daily
  • Max: 480 mg once daily
  • Consider starting dose of 120 mg once daily in elderly and small patients
  • Blood pressure effect seen within first week of therapy
  • May take without regard to food. Capsule can be opened and sprinkled on applesauce. Applesauce should be swallowed immediately without chewing and followed by a glass of water.
Kidney disease
  • About 70% of verapamil dose is excreted by the kidneys. Use caution in patients with impaired renal function and monitor for abnormal prolongation of the PR interval.
Liver disease
  • Exposure is increased. For patients with severe liver disease, the dose of verapamil should be about 30% of the dose given to patients with normal liver function.

Generic / Price

- YES except for 360 mg dose/$-$$

Verapamil ER (Verelan® PM)

Dosage forms

Capsule, extended-release
  • 100 mg
  • 200 mg
  • 300 mg

Dosing

Hypertension (adults)
  • Starting: 200 mg once daily at bedtime
  • Maintenance: 200 - 400 mg once daily at bedtime
  • Max: 400 mg once daily
  • Consider starting dose of 100 mg once daily in elderly, small patients, kidney disease, and liver disease
  • Blood pressure effect seen within first week of therapy
  • May take without regard to food. Capsule can be opened and sprinkled on applesauce. Applesauce should be swallowed immediately without chewing and followed by a glass of water.
Kidney disease
  • About 70% of verapamil dose is excreted by the kidneys. Use caution in patients with impaired renal function and monitor for abnormal prolongation of the PR interval. Consider a starting dose of 100 mg once daily.
Liver disease
  • Exposure is increased. For patients with severe liver disease, the dose of verapamil should be about 30% of the dose given to patients with normal liver function. Consider a starting dose of 100 mg once daily.

Generic / Price

- NO/$$$$

Lotrel® (amlodipine + benazepril)

Dosage forms

Capsule
  • Amlodipine - Benazepril
    • 2.5 mg - 10 mg
    • 5 mg - 10 mg
    • 5 mg - 20 mg
    • 5 mg - 40 mg
    • 10 mg - 20 mg
    • 10 mg - 40 mg

Dosing

Hypertension
  • Starting: 2.5 mg/10 mg once daily
  • Maintenance: 2.5 mg/10 mg - 10 mg/40 mg once daily
  • Max: 10 mg/40 mg once daily
  • May take without regard to food
  • Antihypertensive effect typically seen within 2 weeks

Generic / Price

- YES/$

Prestalia® (amlodipine + perindopril)

Dosage forms

Tablet
  • Perindopril - Amlodipine
    • 3.5 mg - 2.5 mg
    • 7 mg - 5 mg
    • 14 mg - 10 mg

Dosing

Hypertension
  • Starting: 3.5 mg/2.5 mg once daily
  • Maintenance: 3.5 mg/2.5 mg - 14 mg/10 mg once daily
  • Max: 14 mg/10 mg once daily
  • Increase dose at intervals of 1 to 2 weeks
  • May take without regard to food

Generic / Price

- NO/$$$$

Tarka® (verapamil ER + trandolapril)

Dosage forms

Tablet
  • Trandolapril - Verapamil ER
    • 2 mg - 180 mg
    • 1 mg - 240 mg
    • 2 mg - 240 mg
    • 4 mg - 240 mg

Dosing

Hypertension
  • Dosing: Trandolapril is dosed at 1 - 4 mg a day given in one or two divided doses. Verapamil ER is dosed at 120 - 480 mg a day given in one or two divided doses.
  • In trials, Tarka was dosed once daily
  • Take with food

Generic / Price

- YES/$-$$

Azor® (amlodipine + olmesartan)

Dosage forms

Tablet
  • Amlodipine - Olmesartan
    • 5 mg - 20 mg
    • 5 mg - 40 mg
    • 10 mg - 20 mg
    • 10 mg - 40 mg

Dosing

Hypertension
  • Starting: 5 mg/20 mg once daily
  • Maintenance: 5 mg/20 mg - 10 mg/40 mg once daily
  • Max: 10 mg/40 mg once daily
  • Titrate dose at intervals of 1 - 2 weeks
  • May take without regard to food

Generic / Price

- YES/$

Exforge® (amlodipine + valsartan)

Dosage forms

Tablet
  • Amlodipine - Valsartan
    • 5 mg - 160 mg
    • 5 mg - 320 mg
    • 10 mg - 160 mg
    • 10 mg - 320 mg

Dosing

Hypertension
  • Starting: 5 mg/160 mg once daily
  • Maintenance: 5 mg/160 mg - 10 mg/320 mg once daily
  • Max: 10 mg/320 mg once daily
  • Full antihypertensive effect typically seen within 2 weeks
  • May take without regard to food

Generic / Price

- YES/$

Twynsta® (amlodipine + telmisartan)

Dosage forms

Tablet
  • Telmisartan - Amlodipine
    • 40 mg - 5 mg
    • 40 mg - 10 mg
    • 80 mg - 5 mg
    • 80 mg - 10 mg

Dosing

Hypertension
  • Starting: 40 mg/5 mg once daily
  • Maintenance: 40 mg/5 mg - 80 mg/10 mg once daily
  • Max: 80 mg/10 mg once daily
  • Most of the antihypertensive effect is typically seen within 2 weeks
  • May take without regard to food

Generic / Price

- YES/$$

Exforge HCT® (amlodipine + valsartan + HCTZ)

Dosage forms

Tablet
  • Amlodipine - Valsartan - HCTZ
    • 5 mg - 160 mg - 12.5 mg
    • 5 mg - 160 mg - 25 mg
    • 10 mg - 160 mg - 12.5 mg
    • 10 mg - 160 mg - 25 mg
    • 10 mg - 320 mg - 25 mg

Dosing

Hypertension
  • Starting: 5/160/12.5 once daily
  • Maintenance: 5/160/12.5 mg - 10/320/25 mg once daily
  • Max: 10/320/25 mg once daily
  • Titrate dose at intervals of 2 weeks
  • Full antihypertensive effect is seen after 2 weeks
  • May take without regard to food

Generic / Price

- YES/$$

Tribenzor® (amlodipine + olmesartan + HCTZ)

Dosage forms

Tablet
  • Amlodipine - Olmesartan - HCTZ
    • 5 mg - 20 mg - 12.5 mg
    • 5 mg - 40 mg - 12.5 mg
    • 5 mg - 40 mg - 25 mg
    • 10 mg - 40 mg - 12.5 mg
    • 10 mg - 40 mg - 25 mg

Dosing

Hypertension
  • Starting: 5/20/12.5 mg once daily
  • Maintenance: 5/20/12.5 mg - 10/40/25 mg once daily
  • Max: 10/40/25 mg once daily
  • Titrate dose at intervals of 2 weeks
  • May take without regard to food

Generic / Price

- YES/$$

Caduet® (amlodipine + atorvastatin)

Dosage forms

Tablet
  • Amlodipine - Atorvastatin
    • 2.5 mg - 10 mg
    • 2.5 mg - 20 mg
    • 2.5 mg - 40 mg
    • 5 mg - 10 mg
    • 5 mg - 20 mg
    • 5 mg - 40 mg
    • 5 mg - 80 mg
    • 10 mg - 10 mg
    • 10 mg - 20 mg
    • 10 mg - 40 mg
    • 10 mg - 80 mg

Dosing

Hypertension / Hyperlipidemia
  • Starting: 2.5 mg/10 mg once daily
  • Maintenance: 2.5 mg/10 mg - 10 mg/80 mg once daily
  • Max: 10 mg/80 mg once daily
  • May take without regard to food

Generic / Price

- YES/$$

Consensi® (amlodipine + celecoxib)

Dosage forms

Tablet
  • Amlodipine - Celecoxib
    • 2.5 mg - 200 mg
    • 5 mg - 200 mg
    • 10 mg - 200 mg

Dosing

Hypertension / Osteoarthritis
  • Starting: 2.5 - 5 mg/200 mg once daily
  • Maintenance: 2.5 - 10 mg/200 mg once daily
  • Max: 10 mg/200 mg once daily
  • Adjust dose every 7 - 14 days
  • May take without regard to food
  • Celecoxib is a selective NSAID

Generic / Price

- NO/$$$$










Pricing legend
  • $ = 0 - $50
  • $$ = $51 - $100
  • $$$ = $101 - $150
  • $$$$ = > $151
  • Pricing based on one month of therapy at standard dosing in an adult
  • Pricing based on information from GoodRX.com®
  • Pricing may vary by region and availability