DPP-4 INHIBITOR DOSING









Alogliptin (Nesina®)

Dosage forms

Tablet
  • 6.25 mg
  • 12.5 mg
  • 25 mg

Dosing

Type 2 diabetes
  • Dosing: 25 mg once daily
  • Max: 25 mg once daily
  • May take without regard to food

Generic / Price

- YES/$$$

Linagliptin (Tradjenta®)

Dosage forms

Tablet
  • 5 mg

Dosing

Type 2 diabetes
  • Dosing: 5 mg once daily
  • Max: 5 mg once daily
  • May take without regard to food

Generic / Price

- NO/$$$$

Saxagliptin (Onglyza®)

Dosage forms

Tablet
  • 2.5 mg
  • 5 mg

Dosing

Type 2 diabetes
  • Dosing: 2.5 - 5 mg once daily
  • Max: 5 mg once daily
  • May take without regard to food

Generic / Price

- NO/$$$$

Other

  • Do not cut or split tablets

Sitagliptin (Januvia®)

Dosage forms

Tablet
  • 25 mg
  • 50 mg
  • 100 mg

Dosing

Type 2 diabetes
  • Dosing: 100 mg once daily
  • Max: 100 mg once daily
  • May take without regard to food

Generic / Price

- NO/$$$$



Janumet® (sitagliptin + metformin)

Dosage forms

Tablet
  • Sitagliptin - Metformin
    • 50 mg - 500 mg
    • 50 mg - 1000 mg

Dosing

Type 2 diabetes
  • Starting: 50/500 mg twice daily with meals
  • Max: 50/1000 mg twice daily with meals
  • Take with meals

Generic / Price

- NO/$$$$

Other

  • Do not break or cut Janumet

Janumet® XR (sitagliptin + metformin ER)

Dosage forms

Tablet, extended-release
  • Sitagliptin - Metformin ER
    • 50 mg - 500 mg
    • 50 mg - 1000 mg
    • 100 mg - 1000 mg

Dosing

Type 2 diabetes
  • Starting: 100/1000 mg once daily with evening meal
  • Max: 100/2000 mg once daily
  • Take with evening meal

Generic / Price

- NO/$$$$

Other

  • Do not split, crush, or chew tablets
  • There have been reports of incompletely dissolved Janumet XR tablets seen in the feces. It is not known whether this material seen in feces contains active drug. If tablet is repeatedly seen in feces, assess adequacy of glycemic control.

Jentadueto® (linagliptin + metformin)

Dosage forms

Tablet
  • Linagliptin - Metformin
    • 2.5 mg - 500 mg
    • 2.5 mg - 850 mg
    • 2.5 mg - 1000 mg

Dosing

Type 2 diabetes
  • Starting: 2.5/500 mg twice daily
  • Max: 2.5/1000 mg twice daily
  • Take with meals

Generic / Price

- NO/$$$$

Jentadueto® XR (linagliptin + metformin ER)

Dosage forms

Tablet, extended-release
  • Linagliptin - Metformin ER
    • 2.5 mg - 1000 mg
    • 5 mg - 1000 mg

Dosing

Type 2 diabetes
  • Starting: 5/1000 mg once daily with a meal
  • Max: 5/2000 mg once daily
  • Take with a meal

Generic / Price

- NO/$$$$

Other

  • Do not split, chew, crush, or dissolve tablet
  • Incompletely dissolved tablets have been reported with other metformin ER products. If a tablet is seen in the feces, assess adequacy of glycemic control.

Kazano® (alogliptin + metformin)

Dosage forms

Tablet
  • Alogliptin - Metformin
    • 12.5 mg - 500 mg
    • 12.5 mg - 1000 mg

Dosing

Type 2 diabetes
  • Dosing: 12.5/500 - 12.5/1000 mg twice daily
  • Max: 12.5/1000 mg twice daily
  • Take with food

Generic / Price

- NO/$$$$

Other

  • Do not split tablets

Kombiglyze™ XR (saxagliptin + metformin ER)

Dosage forms

Tablet, extended-release
  • Saxagliptin - Metformin ER
    • 5 mg - 500 mg
    • 5 mg - 1000 mg
    • 2.5 mg - 1000 mg

Dosing

Type 2 diabetes
  • Starting: 5/500 mg once daily with evening meal
  • Max: saxagliptin 5 mg/day; metformin 2000 mg/day
  • Take with evening meal

Generic / Price

- NO/$$$$

Other

  • Do not crush, cut, or chew tablets
  • Occasionally, the inactive ingredients of Kombiglyze XR will be eliminated in the feces as a soft, hydrated mass that may resemble the original tablet



Oseni® (pioglitazone + alogliptin)

Dosage forms

Tablet
  • Alogliptin - Pioglitazone
    • 12.5 mg - 15 mg
    • 12.5 mg - 30 mg
    • 12.5 mg - 45 mg
    • 25 mg - 15 mg
    • 25 mg - 30 mg
    • 25 mg - 45 mg

Dosing

Type two diabetes
  • Starting: 25/15 - 25/30 mg once daily
  • Max: 25/45 mg once daily
  • Titrate to effect
  • May take without regard to food

Generic / Price

- YES/$$$-$$$$

Other

  • Do not split tablets



Glyxambi® (empagliflozin + linagliptin)

Dosage forms

Tablet
  • Empagliflozin - Linagliptin
    • 10 mg - 5 mg
    • 25 mg - 5 mg

Dosing

Type 2 diabetes
  • Starting: 10/5 mg once daily
  • Maintenance: 10/5 - 25/5 mg once daily
  • Max: 25/5 mg once daily
  • May take without regard to food

Generic / Price

- NO/$$$$

Qtern® (dapagliflozin + saxagliptin)

Dosage forms

Tablet
  • Dapagliflozin - Saxagliptin
    • 5 mg - 5 mg
    • 10 mg - 5 mg

Dosing

Type 2 diabetes
  • Starting: 5/5 mg once daily
  • Maintenance: 5/5 - 10/5 mg once daily
  • Max: 10/5 mg once daily
  • Take in the morning
  • May take without regard to food

Generic / Price

- NO/$$$$

Other

  • Swallow whole. Do not crush, cut, or chew tablets.
  • Do not use in patients with GFR < 45 ml/min
  • Do not use with CYP3A4 strong inhibitors

Steglujan® (ertugliflozin + sitagliptin)

Dosage forms

Tablet
  • Ertugliflozin - Sitagliptin
    • 5 mg - 100 mg
    • 15 mg - 100 mg

Dosing

Type 2 diabetes
  • Starting: 5/100 mg once daily
  • Maintenance: 5/100 - 15/100 mg once daily
  • Max: 15/100 mg once daily
  • Take in the morning
  • May take without regard to food

Generic / Price

- NO/$$$$

Trijardy® XR (empagliflozin + linagliptin + metformin ER)

Dosage forms

Tablet, extended-release
  • Empagliflozin - Linagliptin - Metformin ER
    • 5 mg - 2.5 mg - 1000 mg
    • 10 mg - 5 mg - 1000 mg
    • 12.5 mg - 2.5 mg - 1000 mg
    • 25 mg - 5 mg - 1000 mg

Dosing

Type 2 diabetes
  • Starting:
    • For patients switching from metformin with or without linagliptin, use a dosage that gives a similar total daily dose of metformin and a total daily dose of empagliflozin 10 mg and linagliptin 5 mg
    • For patients switching from metformin and any regimen containing empagliflozin with or without linagliptin, use a dosage that gives a similar total daily dose of metformin, the same total daily dose of empagliflozin, and linagliptin 5 mg
  • Max: Empagliflozin 25 mg/day | Linagliptin 5 mg/day | Metformin ER 2000 mg/day
  • Take once daily with a meal in the morning

Generic / Price

- NO/$$$$

Other

  • Swallow tablets whole. Do not crush, cut, dissolve, or chew.
  • Incompletely dissolved tablets may be seen in the feces. Patients should report this finding to their healthcare provider, and the provider should assess their glycemic control.







  • NOTE: Information on metabolic pathways presented here is from the manufacurer's PI, FDA website, and a handful of published reviews. Other metabolic pathways may exist; therefore, the information is not meant to be all-inclusive.
Metabolism and clearance
Drug CYP2C8 CYP3A4 P-glycoprotein OAT
Alogliptin No significant liver metabolism - -
Linagliptin - Substrate and inhibitor Substrate and inhibitor -
Saxagliptin - Substrate Substrate -
Sitagliptin Substrate Substrate Substrate Substrate



Pricing legend
  • $ = 0 - $50
  • $$ = $51 - $100
  • $$$ = $101 - $150
  • $$$$ = > $150
  • Pricing based on one month of therapy at standard dosing in an adult
  • Pricing based on information from GoodRX.com®
  • Pricing may vary by region and availability