ENaC INHIBITOR DOSING









Amiloride (Midamor®)

Dosage forms
Tablet
  • 5 mg

Dosing
Prevention / treatment of hypokalemia with other diuretics
  • Starting: 5 mg once daily
  • Maintenance: 5 - 10 mg once daily
  • Max: 20 mg/day
  • Doses > 10 mg a day have not been studied extensively
  • Take with food

Generic / Price - YES/$
Other
  • Typically prescribed with thiazide or loop diuretics for its potassium-conserving effects
  • Amiloride has insignificant diuretic and antihypertensive effects

Triamterene (Dyrenium®)

Dosage forms
Capsule
  • 50 mg
  • 100 mg

Dosing
Prevention / treatment of hypokalemia with other diuretics
  • Dosing: 37.5 - 75 mg a day
  • May take without regard to food. Food may decrease stomach upset with monotherapy.
Edema (monotherapy)
  • Starting: 100 mg twice a day after meals
  • Max: 300 mg/day
  • May take without regard to food. Food may decrease stomach upset with monotherapy.

Generic / Price - YES/$$-$$$
Other
  • Typically prescribed with thiazide or loop diuretics for its potassium-conserving effects
  • May promote increased diuresis when patients prove resistant or only partially responsive to thiazides or other diuretics because of secondary hyperaldosteronism



Dyazide® (HCTZ + triamterene)

Dosage forms
Capsule
  • HCTZ - Triamterene
    • 25 mg - 37.5 mg

Dosing
Hypertension or Edema
  • Dosing: 25/37.5 - 50/75 mg once daily
  • Max: 50/75 mg once daily
  • May take without regard to food

Generic / Price - YES/$
Other
  • Triamterene helps prevent potassium loss from HCTZ but has no significant effect on blood pressure

Maxzide® (HCTZ + triamterene)

Dosage forms
Tablet
  • HCTZ - Triamterene
    • 25 mg - 37.5 mg
    • 50 mg - 75 mg

Dosing
Hypertension or Edema
  • Dosing: 25/37.5 - 50/75 mg once daily
  • Max: 50/75 mg once daily
  • May take without regard to food

Generic / Price - YES/$
Other
  • Triamterene helps prevent potassium loss from HCTZ but has no significant effect on blood pressure

Moduretic® (HCTZ + amiloride)

Dosage forms
Tablet
  • Amiloride - HCTZ
    • 5 mg - 50 mg

Dosing
Hypertension or Edema
  • Dosing: 5/50 mg - 10/100 mg/day
  • May be given once daily or in divided doses
  • Take with food

Generic / Price - YES/$
Other
  • Amiloride helps prevent potassium loss from HCTZ but has no significant effect on blood pressure











Pricing legend
  • $ = 0 - $50
  • $$ = $51 - $100
  • $$$ = $101 - $150
  • $$$$ = > $150
  • Pricing based on one month of therapy at standard dosing in an adult
  • Pricing based on information from GoodRX.com®
  • Pricing may vary by region and availability