• Values are average percent change from baseline, except triglycerides which is median percent change from baseline
  • Reference [1]
Ezetimibe monotherapy 12-week trial
Ezetimibe 10 mg (N=1288) Placebo (N=431)
Total -13% 0%
LDL -18% +1%
Triglycerides -8% 0%
HDL +1% -2%

  • Values are average percent change from baseline, except triglycerides which is median percent change from baseline
  • Statins in trial - 40% atorvastatin, 31% simvastatin, 29% others (pravastatin, fluvastatin, cerivastatin, lovastatin)
  • Reference [1]
Ezetimibe added to statins 8-week trial
Ezetimibe + statin (N=379) Placebo + statin (N=390)
Total -17% -2%
LDL -25% -4%
Triglycerides -14% -3%
HDL +3% +1%




  • Numbers are percent of patients in controlled trials
  • Reference [1]
Consecutive liver enzyme elevations (≥ 3 X ULN)
Ezetimibe monotherapy 0.5%
Placebo 0.3%
Ezetimibe + statin 1.3%
Placebo + statin 0.4%