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GERD













gerd mechanism illustration



























  • Reference: Manufacturer package insert
Proton pump inhibitors
Dexlansoprazole (Dexilant®)
  • Dosage forms
    • Capsule: 30 mg, 60 mg
    • Generic available | $$$$ for 30 capsules
    • No OTC version

  • Dosing (≥ 12 years old and adults)
    • GERD: 30 mg once daily
    • Healing of EE: 60 mg once daily for up to 8 weeks
Esomeprazole (Nexium®)
  • Dosage forms
    • Prescription
      • Capsule: 20 mg, 40 mg
      • Powder for suspension: 2.5, 5, 10, 20, 40 mg packet
      • Generic capsule: $ for 30 capsules | Powder (no generic): $$$$ for 30 packets
    • OTC
      • 20 mg capsules and tablets
      • Generic available | $ for 30 capsules

  • Dosing (≥ 12 years old and adults)
    • GERD: 20 mg once daily
    • Healing of EE: 20 - 40 mg once daily for 4 to 8 weeks

  • Dosing (1 - 11 years)
    • GERD: 10 mg once daily for up to 8 weeks
    • Healing of EE:
      • < 44 lbs (20 kg): 10 mg once daily for 8 weeks
      • > 44 lbs (20 kg): 10 - 20 mg once daily for 8 weeks

  • Dosing (1 month - 1 year)
    • Treatment of EE:
      • 6.6 lbs (3 kg) - 11 lbs (5 kg): 2.5 mg once daily for up to 6 weeks
      • 11 lbs (5 kg) - 16.5 lbs (7.5 kg): 5 mg once daily for up to 6 weeks
      • 16.5 lbs (7.5 kg) - 26.4 lbs (12 kg): 10 mg once daily for up to 6 weeks

  • Other
Lansoprazole (Prevacid®)
  • Dosage forms
    • Prescription
      • Capsule and ODT: 15 mg, 30 mg
      • Generic available | $ for 30 capsules, $$-$$$ for ODT
    • OTC
      • 15 mg
      • Comes in capsule and ODT
      • Generic available | $ for 30 capsules and ODT

  • Dosing (≥ 12 years old and adults)
    • GERD: 15 mg once daily
    • Healing of EE: 30 mg once daily for up to 8 weeks
    • Duodenal ulcers: 15 mg once daily for 4 weeks
    • Gastric ulcers: 30 mg once daily for up to 8 weeks

  • Dosing (1 - 11 years)
    • GERD and EE:
      • ≤ 66 lbs (30 kg): 15 mg once daily for up to 12 weeks
      • > 66 lbs (30 kg): 30 mg once daily for up to 12 weeks
Omeprazole (Prilosec®)
  • Dosage forms
    • Prescription
      • Capsule: 10 mg, 20 mg, 40 mg
      • Powder for suspension: 2.5 and 10 mg packet
      • Generic capsule: $ for 30 capsules | Powder (no generic): $$$$ for 30 packets
    • OTC
      • 20 mg capsules and tablets
      • Generic available | $ for 30 tablets

  • Dosing (adults)
    • GERD: 20 mg once daily
    • Healing of EE: 20 mg once daily for 4 - 8 weeks
    • Duodenal ulcers: 20 mg once daily for 4 weeks
    • Gastric ulcers: 40 mg once daily for 4 - 8 weeks

  • Dosing (1 - 16 years)
    • GERD and EE:
      • 11 lbs (5 kg) - 22 lbs (10 kg): 5 mg once daily for 4 - 8 weeks
      • 22 lbs (10 kg) - 44 lbs (20 kg): 10 once daily for 4 - 8 weeks
      • ≥ 44 lbs (20 kg): 20 once daily for 4 - 8 weeks

  • Dosing (1 month - 1 year)
    • Treatment of EE:
      • 6.6 lbs (3 kg) - 11 lbs (5 kg): 2.5 mg once daily for up to 6 weeks
      • 11 lbs (5 kg) - 22 lbs (10 kg): 5 mg once daily for up to 6 weeks
      • ≥ 22 lbs (10 kg): 10 mg once daily for up to 6 weeks

  • Other
Omeprazole + sodium bicarbonate (Zegerid®)
  • Dosage forms
    • Prescription
      • Capsule: 20/1100 mg, 40/1100 mg
      • Powder for suspension: 20/1680 mg and 40/1680 mg packet
      • Generic capsule: $ for 30 | Powder (no generic): $$$$ for #30
    • OTC (capsule)
      • 20/1100 mg
      • Generic available | $ for 30 tablets

  • Dosing based on omeprazole component (adults)
    • GERD: 20 mg once daily
    • Healing of EE: 20 mg once daily for 4 - 8 weeks
    • Duodenal ulcers: 20 mg once daily for 4 weeks
    • Gastric ulcers: 40 mg once daily for 4 - 8 weeks

  • Other
    • Sodium bicarbonate is an antacid
    • Not recommended with clopidogrel (Plavix®). See clopidogrel and PPIs.
Pantoprazole (Protonix®)
  • Dosage forms
    • Tablet: 20 mg, 40 mg
    • Granules for suspension: 40 mg packet
    • Generic tablets: $ for 30 tablets | Generic granules: $$$$ for 30 packets
    • No OTC version

  • Dosing (adults)
    • GERD: 40 mg once daily
    • Healing of EE: 40 mg once daily for up to 8 weeks

  • Dosing (children ≥ 5 years old)
    • Treatment of EE:
      • 33 lbs (15 kg) - 88 lbs (40 kg): 20 mg once daily for up to 8 weeks
      • ≥ 88 lbs (40 kg): 40 mg once daily for up to 8 weeks
Rabeprazole (Aciphex®)
  • Dosage forms
    • Tablet: 20 mg
    • Generic available | $ for 30 tablets
    • No OTC version

  • Dosing (≥ 12 years old and adults)
    • GERD: 20 mg once daily
    • Healing of EE: 20 mg once daily for 4 - 8 weeks
    • Duodenal ulcers: 20 mg once daily for up to 4 weeks





















Pricing legend
  • $ = 0 - $50
  • $$ = $51 - $100
  • $$$ = $101 - $150
  • $$$$ = > $150
  • Pricing based on one month of therapy at standard dosing in an adult
  • Pricing based on information from GoodRX.com®
  • Pricing may vary by region and availability