GLITAZONE DOSING





Pioglitazone (Actos®)

Dosage forms

Tablet
  • 15 mg
  • 30 mg
  • 45 mg

Dosing

Type two diabetes
  • Starting: 15 - 30 mg once daily
  • Maintenance: 15 - 45 mg once daily
  • Max: 45 mg once daily
  • May take without regard to food

Generic / Price

- YES/$

Other

  • For patients with NYHA I and II heart failure, starting dose should be 15 mg
  • Dose should not exceed 15 mg/day when taken with CYP2C8 strong inhibitor

Rosiglitazone (Avandia®)

Dosage forms

Tablet
  • 2 mg
  • 4 mg
  • 8 mg

Dosing

Type two diabetes
  • Starting: 4 mg/day
  • Maintenance: 4 - 8 mg/day
  • Max: 8 mg/day
  • May be given in 1 or 2 divided doses
  • May take without regard to food

Generic / Price

- NO/$$$$

Other




Actoplus met® (pioglitazone + metformin)

Dosage forms

Tablet
  • Pioglitazone - Metformin
    • 15 mg - 500 mg
    • 15 mg - 850 mg

Dosing

Type 2 diabetes
  • Starting: 15/500 mg twice daily or 15/850 mg once daily
  • Max: pioglitazone 45 mg/day | metformin 2550 mg/day
  • Titrate to effect
  • May be given in one or two divided doses
  • Take with food to decrease GI upset

Generic / Price

- YES/$$

Actoplus met XR® (pioglitazone + metformin ER)

Dosage forms

Tablet, extended-release
  • Pioglitazone - Metformin ER
    • 15 mg - 1000 mg
    • 30 mg - 1000 mg

Dosing

Type 2 diabetes
  • Starting: 15/1000 - 30/1000 mg once daily
  • Max: pioglitazone 45 mg/day | metformin ER 2000 mg/day
  • Titrate to effect
  • May be given in one or two divided doses
  • Take with food to decrease GI upset

Generic / Price

- NO/$$$$

Other

  • Swallow whole. Do not crush, cut, or chew tablet.
  • Inactive ingredients may occasionally be eliminated in the feces as a soft mass that may resemble the original tablet

Avandamet® (rosiglitazone + metformin)

Dosage forms

Tablet
  • Rosiglitazone - Metformin
    • 2 mg - 500 mg
    • 2 mg - 1000 mg
    • 4 mg - 500 mg
    • 4 mg - 1000 mg

Dosing

Type 2 diabetes
  • Starting: 2/500 mg twice daily
  • Max: rosiglitazone 8 mg/day | metformin 2000 mg/day
  • Titrate to effect
  • Take with food to decrease GI upset

Generic / Price

- NO/$$$$



Duetact® (pioglitazone + glimepiride)

Dosage forms

Tablet
  • Pioglitazone - Glimepiride
    • 30 mg - 2 mg
    • 30 mg - 4 mg

Dosing

Type 2 diabetes
  • Starting: 30/2 - 30/4 mg once daily
  • Max: 30/4 mg once daily
  • Titrate to effect
  • Take with first main meal

Generic / Price

- YES/$$$



Oseni® (pioglitazone + alogliptin)

Dosage forms

Tablet
  • Alogliptin - Pioglitazone
    • 12.5 mg - 15 mg
    • 12.5 mg - 30 mg
    • 12.5 mg - 45 mg
    • 25 mg - 15 mg
    • 25 mg - 30 mg
    • 25 mg - 45 mg

Dosing

Type two diabetes
  • Starting: 25/15 - 25/30 mg once daily
  • Max: 25/45 mg once daily
  • Titrate to effect
  • May take without regard to food

Generic / Price

- YES/$$$-$$$$

Other

  • Do not split tablets











Pricing legend
  • $ = 0 - $50
  • $$ = $51 - $100
  • $$$ = $101 - $150
  • $$$$ = > $150
  • Pricing based on one month of therapy at standard dosing in an adult
  • Pricing based on information from GoodRX.com®
  • Pricing may vary by region and availability