GLITAZONE DOSING

All dosing is for ADULTS unless otherwise specified
PRICING INFO


Drug Dosage form Dosing Generic/Price Food / Other
Pioglitazone

Actos®
Tablet
  • 15 mg
  • 30 mg
  • 45 mg
Type two diabetes
  • Starting: 15 - 30 mg once daily
  • Maintenance: 15 - 45 mg once daily
  • Max: 45 mg once daily
  • See precautions for dosing in kidney and liver disease
YES/$ FOOD
  • May take without regard to food

OTHER
  • For patients with NYHA I and II heart failure, starting dose should be 15 mg
  • With CYP2C8 strong inhibitor - do not exceed 15 mg a day

Drug Dosage form Dosing Generic/Price Food / Other
Rosiglitazone

Avandia®
Tablet
  • 2 mg
  • 4 mg
  • 8 mg
Type two diabetes
  • Starting: 4 mg/day
  • Maintenance: 4 - 8 mg/day
  • Max: 8 mg/day
  • May be given in 1 or 2 divided doses
  • See precautions for dosing in kidney and liver disease
NO/$$$$ FOOD
  • May take without regard to food

OTHER

  • COMBINATION PRODUCT WITH METFORMIN

Drug Dosage form Dosing Generic/Price Food/Other
Actoplus met®

pioglitazone + metformin
Pioglitazone - Metformin
  • 15 mg - 500 mg
  • 15 mg - 850 mg
  • Comes in tablet form
Type two diabetes
  • Starting: 15/500 mg twice daily or 15/850 mg once daily
  • Max: pioglitazone 45 mg/day | metformin 2550 mg/day
  • Titrate to effect
  • May be given in one or two divided doses
YES/$$ FOOD
  • Take with food to decrease GI upset

OTHER

Drug Dosage form Dosing Generic/Price Food/Other
Actoplus met XR®

pioglitazone + metformin extended-release
Pioglitazone - Metformin ER
  • 15 mg - 1000 mg
  • 30 mg - 1000 mg
  • Comes in tablet form
Type two diabetes
  • Starting: 15/1000 - 30/1000 mg once daily
  • Max: pioglitazone 45 mg/day | metformin ER 2000 mg/day
  • Titrate to effect
  • May be given in one or two divided doses
NO/$$$$ FOOD
  • Take with food to decrease GI upset

OTHER
  • Swallow whole. Do not crush, cut, or chew tablet.
  • Inactive ingredients may occasionally be eliminated in the feces as a soft mass that may resemble the original tablet

Drug Dosage form Dosing Generic/Price Food/Other
Avandamet®

rosiglitazone + metformin
Rosiglitazone - Metformin
  • 2 mg - 500 mg
  • 2 mg - 1000 mg
  • 4 mg - 500 mg
  • 4 mg - 1000 mg
  • Comes in tablet form
Type two diabetes
  • Starting: 2/500 mg twice daily
  • Max: rosiglitazone 8 mg/day | metformin 2000 mg/day
  • Titrate to effect
NO/$$$$ FOOD
  • Take with food to decrease GI upset

OTHER

  • COMBINATION PRODUCT WITH SULFONYLUREAS

Drug Dosage form Dosing Generic/Price Food/Other
Duetact®

pioglitazone + glimepiride
Pioglitazone - Glimepiride
  • 30 mg - 2 mg
  • 30 mg - 4 mg
Type two diabetes
  • Starting: 30/2 - 30/4 mg once daily
  • Max: 30/4 mg once daily
  • Titrate to effect
YES/$$$$ FOOD
  • Take with first main meal

OTHER

  • COMBINATION PRODUCTS WITH DPP-4 INHIBITORS

Drug Dosage form Dosing Generic/Price Food/Other
Oseni®

pioglitazone + alogliptin
Alogliptin - Pioglitazone
  • 12.5 mg - 15 mg
  • 12.5 mg - 30 mg
  • 12.5 mg - 45 mg
  • 25 mg - 15 mg
  • 25 mg - 30 mg
  • 25 mg - 45 mg
Type two diabetes
  • Starting: 25/15 - 25/30 mg once daily
  • Max: 25/45 mg once daily
  • Titrate to effect
YES/$$$$ FOOD
  • May take without regard to food

OTHER
  • Do not split tablets