INSULIN CHART




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Admelog® (insulin lispro)

Dosage forms

SoloStar® Pen (100 units/ml)
  • 3 ml pen
  • Comes in carton of 5 pens
  • Compatible with BD Ultra-Fine®, Ypsomed Clickfine®, and Owen Mumford Unifine® needles
Vial (100 units/ml)
  • Comes in 3 ml and 10 ml vials

Pharmacokinetics

Onset of action
  • 10 - 30 minutes
Duration of action
  • 3 - 5 hours
Peak effect
  • 1/2 - 2 hours

Mixing

- DO NOT MIX with other insulins

Dosing

  • Dosage will vary by patient
  • Admelog® is a premeal (prandial) insulin. See insulin dosing for more.
  • Inject Admelog® within 15 minutes before a meal or immediately after a meal

Other

  • Admelog® should be clear and colorless
  • Admelog® is compatible with some insulin pumps

Storage

Unpunctured, refrigerated
  • Vials and pens are good until expiration date on product
Unpunctured, room temp
  • Vials and pens are good for 28 days
Punctured (in use)
  • Pens should be kept at room temperature (do not refrigerate)
  • Vials may be refrigerated or kept at room temp
  • Vials and pens are good for 28 days

Afrezza® (inhaled insulin)

Dosage forms

Cartridge
  • 4 unit cartridge of inhalation powder
  • 8 unit cartridge of inhalation powder
Packaged as follows:
  • 60 four unit cartridges
  • 90 four unit cartridges
  • 90 eight unit cartridges
  • 60 four unit and 30 eight unit
  • 30 four unit and 60 eight unit
  • 90 four unit and 90 eight unit

Pharmacokinetics

Onset of action
  • 10 - 30 minutes
Duration of action
  • ∼ 2.6 hours
Peak effect
  • ∼ 53 minutes

Dosing

Insulin-naïve patients
  • 4 units with the start of each meal
Patients on injectable insulin

Other


Storage

Packaging
  • Afrezza® comes in a sealed foil package with 2 blister cards inside
  • Each blister card has 5 rows of 3 cartridges
  • 3 cartridges are under one blister
  • Before use, cartridge and inhaler should be at room temperature for 10 minutes
  • Inhaler should be thrown away after 15 days
Refrigerated
  • Sealed foil package is good until expiration date
Room temperature
  • Sealed foil package - use within 10 days
  • Sealed blister cards + strips - use within 10 days
  • Opened blister - use within 3 days

Apidra® (insulin glulisine)

Dosage forms

Vial (100 units/ml)
  • 10 ml vial
SoloStar® Pen (100 units/ml)
  • 3 ml pen
  • Comes in package of 5 pens
  • Compatible with all BD® pen needles

Pharmacokinetics

Onset of action
  • 10 - 30 minutes
Duration of action
  • 3 - 5 hours
Peak effect
  • 1/2 - 2 hours

Mixing

  • Mix with NPH only
  • Draw Apidra® first, then NPH
  • Inject immediately

Dosing

  • Dosage will vary by patient
  • Apidra® is a premeal (also called prandial) insulin. See insulin dosing for more.
  • Inject Apidra® within 15 minutes before a meal or within 20 minutes after starting a meal

Other

  • Apidra® should be clear and colorless
  • Apidra® is compatible with some insulin pumps

Storage

Unpunctured, refrigerated
  • Vials and pens are good until expiration date on product
Unpunctured, room temp
  • Vials and pens are good for 28 days
Punctured (in use)
  • Pens should be kept at room temperature (do not refrigerate)
  • Vials may be refrigerated or kept at room temperature
  • Vials and pens are good for 28 days

Fiasp® (insulin aspart)

Dosage forms

Vial (100 units/ml)
  • 10 ml vial
FlexTouch Pen® (100 units/ml)
  • 3 ml pen
  • Comes in carton of 5 pens
  • Compatible with NovoFine, Novofine Plus, NovoTwist, and BD pen needles

Pharmacokinetics

Onset of action
  • 15 - 20 minutes
Duration of action
  • 5 - 7 hours
Peak effect
  • 90 - 133 minutes

Mixing

- DO NOT MIX with other insulins

Dosing

  • Dosage will vary by patient
  • Fiasp® is a premeal (prandial) insulin. See insulin dosing for more.
  • Inject Fiasp® at the start of a meal or within 20 minutes after starting a meal
  • Fiasp® is approved for use in some insulin pumps

Other

  • Fiasp® should be clear and colorless
  • Fiasp® is approved for use in some insulin pumps

Storage

Unpunctured, refrigerated
  • Vials and pens are good until expiration date on product
Unpunctured, room temp
  • Vials and pens are good for 28 days
Punctured
  • Vials and pens may be refrigerated or kept at room temperature
  • Vials and pens are good for 28 days

Humalog® (insulin lispro)

Dosage forms



  • * For use in HumaPen® Luxura HD and HumaPen® Memoir
  • Tempo pen connects to a phone app and relays dosing information
  • Dose is dialed in 0.5 unit increments
  • Reference: Humalog PI
Humalog products
Name Volume Concentration Max dose per injection Package size
U-100 vial 3 ml and 10 ml 100 units/ml N/A 1 vial
U-100 cartridge * 3 ml 100 units/ml N/A 5 cartridges
U-100 KwikPen 3 ml 100 units/ml 60 units 5 pens
U-100 Tempo Pen 3 ml 100 units/ml 60 units 5 pens
U-100 Junior KwikPen 3 ml 100 units/ml 30 units 5 pens
U-200 KwikPen 3 ml 200 units/ml 60 units 2 pens
Needles
  • KwikPen® is compatible with all BD® pen needles

Pharmacokinetics

Onset of action
  • 10 - 30 minutes
Duration of action
  • 3 - 5 hours
Peak effect
  • 1/2 - 2 hours

Mixing

  • Mix with NPH only
  • Draw Humalog® first, then NPH
  • Inject immediately

Dosing

  • Dosage will vary by patient
  • Humalog® is a premeal (prandial) insulin. See insulin dosing for more.
  • Inject Humalog® within 15 minutes before a meal or immediately after a meal

Other

  • Humalog® should be clear and colorless
  • Humalog® is compatible with some insulin pumps
  • HumaPen® Luxura HD is a reusable pen that allows dosing in 0.5 unit increments
  • HumaPen® Memoir records the time, date, and dose of the last 16 injections

Storage

Unpunctured, refrigerated
  • Vials, pens, and cartridges are good until expiration date on product
Unpunctured, room temp
  • Vials, pens, and cartridges are good for 28 days
Punctured (in use)
  • Vials may be refrigerated or kept at room temperature
  • Pens and cartridges should be kept at room temperature (do not refrigerate)
  • Vials, pens, and cartridges are good for 28 days

Lyumjev® (insulin lispro-aabc)

Dosage forms



  • * For use in HumaPen® Luxura HD
  • Dose is dialed in 0.5 unit increments
  • Tempo pen connects to a phone app and relays dosing information
  • Reference: Humalog PI
Lyumjev products
Name Volume Concentration Max dose per injection Package size
U-100 vial 10 ml 100 units/ml N/A 1 vial
U-100 cartridge * 3 ml 100 units/ml N/A 5 cartridges
U-100 KwikPen 3 ml 100 units/ml 60 units 5 pens
U-100 Junior KwikPen 3 ml 100 units/ml 30 units 5 pens
U-100 Tempo Pen 3 ml 100 units/ml 60 units 5 pens
U-200 KwikPen 3 ml 200 units/ml 60 units 2 pens

Pharmacokinetics

Onset of action
  • 15 - 20 minutes
Duration of action
  • 4 - 8 hours
Peak effect
  • 2 - 3 hours

Mixing

- DO NOT MIX with other insulins

Dosing

  • Dosage will vary by patient
  • Lyumjev® is a premeal (prandial) insulin. See insulin dosing for more.
  • Inject Lyumjev® at the start of a meal or within 20 minutes after starting a meal

Other

  • Lyumjev® should be clear and colorless

Storage

Unpunctured, refrigerated
  • Vials, pens, and cartridges are good until expiration date on product
Unpunctured, room temp
  • Vials, pens, and cartridges are good for 28 days
Punctured (in use)
  • Vials may be refrigerated or kept at room temperature
  • Pens and cartridges should be kept at room temperature (do not refrigerate)
  • Vials, pens, and cartridges are good for 28 days

Novolog® (insulin aspart)

Dosage forms

Vial (100 units/ml)
  • 10 ml vial
FlexPen® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5
  • Compatible with NovoFine, Novofine Plus, NovoTwist, and BD pen needles
FlexTouch® Pen (100 units/ml)
  • 3 ml pen
  • Comes in package of 5
  • FlexTouch® pen button maintains the same extension at all doses
  • Compatible with NovoFine® and NovoTwist® pen needles
Cartridge (100 units/ml)
  • 3 ml cartridge
  • for use in NovoPen® reusable pens

Pharmacokinetics

Onset of action
  • 10 - 30 minutes
Duration of action
  • 3 - 5 hours
Peak effect
  • 1 - 3 hours

Mixing

  • Mix with NPH only
  • Draw Novolog® first, then NPH
  • Inject immediately

Dosing

  • Dosage will vary by patient
  • Novolog® is a premeal (also called prandial) insulin. See insulin dosing for more.
  • Inject Novolog® within 5 - 10 minutes before a meal

Other

  • Novolog® should be clear and colorless
  • Novolog® is compatible with some insulin pumps

Storage

Unpunctured, refrigerated
  • Vials, pens, and cartridges are good until expiration date on product
Unpunctured, room temp
  • Vials, pens, and cartridges are good for 28 days
Punctured (in use)
  • Vials may be refrigerated or kept at room temperature
  • Pens and cartridges should be kept at room temperature (do not refrigerate)
  • Vials, pens, and cartridges are good for 28 days



Humulin® R (regular insulin)

Dosage forms

Humulin® R U-100 Vial
  • Contains 100 units/ml
  • Comes in 3 ml and 10 ml vials
Humulin® R U-500 Vial
  • Contains 500 units/ml
  • 20 ml vial
  • A special U-500 syringe must be prescribed with vial
Humulin® R U-500 KwikPen®
  • Contains 500 units/ml
  • 3 ml pen
  • Comes in carton of 2 or 5 pens
  • BD® pen needles are recommended

Pharmacokinetics

Onset of action
  • 30 - 60 minutes
Duration of action
  • 6 - 8 hours
Peak effect
  • 2 - 3 hours

Mixing

  • Mix with NPH only
  • Draw Humulin® R first, then NPH
  • Inject immediately

Dosing

  • Dosage will vary by patient
  • Humulin® R is a premeal (also called prandial) insulin. See insulin dosing for more.
  • Humulin® R should be followed by a meal within approximately 30 minutes of administration

Other

  • Humulin® R should be clear and colorless
  • Humulin® R U-500 should only be prescribed to patients who require > 200 units of insulin per day

Storage U-100

Unpunctured, refrigerated
  • Vials are good until expiration date on product
Unpunctured, room temp
  • Vials are good for 31 days
Punctured (in use)
  • Vials may be refrigerated or kept at room temperature
  • Vials are good for 31 days

Storage U-500

Unpunctured, refrigerated
  • Vials and pens are good until expiration date on product
Unpunctured, room temp
  • Vials are good for 40 days
  • Pens are good for 28 days
Punctured (in use)
  • Pens should be kept at room temperature (do not refrigerate)
  • Vials may be refrigerated or kept at room temperature
  • Pens are good for 28 days
  • Vials are good for 40 days

Novolin® R (regular insulin)

Dosage forms

Vial (100 units/ml)
  • 10 ml vial
Flexpen (100 units/ml)
  • 3 ml pen
  • Comes in carton of 5 pens
  • Compatible with NovoFine, Novofine Plus, NovoTwist, and BD pen needles

Pharmacokinetics

Onset of action
  • 30 - 60 minutes
Duration of action
  • 6 - 8 hours
Peak effect
  • 2 - 3 hours

Mixing

  • Mix with NPH only
  • Draw Novolin® R first, then NPH
  • Inject immediately

Dosing

  • Dosage will vary by patient
  • Novolin® R is a premeal (also called prandial) insulin. See insulin dosing for more.
  • Novolin® R should generally be injected approximately 30 minutes prior to the start of a meal

Other

  • Novolin® R should be clear and colorless

Storage

Unpunctured, refrigerated
  • Vials and pens are good until expiration date on product
Unpunctured, room temp
  • Vials are good for 42 days
  • Pens are good for 28 days
Punctured (in use)
  • Vials and pens should be kept at room temperature (do not refrigerate)
  • Vials are good for 42 days
  • Pens are good for 28 days



Humulin® N | NPH | Human insulin isophane suspension

Dosage forms

Vial (100 units/ml)
  • Comes in 3 ml and 10 ml vials
KwikPen® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5
  • Compatible with BD® pen needles

Pharmacokinetics

Onset of action
  • 2 - 4 hours
Duration of action
  • up to 20 hours
Peak effect
  • 4 - 10 hours

Mixing

  • Humulin® N can be mixed with Regular, Apidra®, Humalog®, and Novolog®
  • Draw Humulin® N after other insulin
  • Inject immediately

Dosing


Other

  • Humulin® N should be mixed before use (see instructions with product)
  • Humulin® N should appear uniformly cloudy with no particulate matter after mixing

Storage

Unpunctured, refrigerated
  • Vials and pens are good until expiration date on product
Unpunctured, room temp
  • Vials are good for 31 days
  • Pens are good for 14 days
Punctured (in use)
  • Vials may be refrigerated or kept at room temp
  • Pens should be kept at room temperature (do not refrigerate)
  • Vials are good for 31 days
  • Pens are good for 14 days

Novolin® N | NPH | Isophane insulin human suspension

Dosage forms

Vial (100 units/ml)
  • 10 ml vial
FlexPen (100 units/ml)
  • 3 ml pen
  • Comes in carton with 5 pens
  • Compatible with NovoFine, Novofine Plus, NovoTwist, and BD pen needles

Pharmacokinetics

Onset of action
  • 2 - 4 hours
Duration of action
  • up to 20 hours
Peak effect
  • 4 - 10 hours

Mixing

  • Novolin® N can be mixed with Regular, Apidra®, Humalog®, and Novolog®
  • Draw Novolin® N after other insulin
  • Inject immediately

Dosing


Other

  • Novolin® N should be mixed before use (see instructions with product)
  • Novolin® N should appear uniformly cloudy with no particulate matter after mixing

Storage

Unpunctured, refrigerated
  • Vials and pens are good until expiration date on product
Unpunctured, room temp
  • Vials are good for 42 days
  • Pens are good for 28 days
Punctured (in use)
  • Vial and pens should be stored at room temperature (do not refrigerate)
  • Vials are good for 42 days
  • Pens are good for 28 days



Basaglar® (insulin glargine)

Dosage forms

Kwikpen (100 units/ml)
  • 3 ml pen
  • Comes in package of 5 pens
  • Compatible with BD® pen needles
Tempo Pen (100 units/ml)
  • 3 ml pen
  • Comes in package of 5 pens
  • Compatible with BD® pen needles
  • Tempo pen connects to a phone app and relays dosing information

Pharmacokinetics

Onset of action
  • 1 - 3 hours
Duration of action
  • 24+ hours
Peak effect
  • No peak

Mixing

- DO NOT MIX with other insulins

Dosing

  • Dosage will vary by patient
  • The recommended starting dose of Basaglar® in patients with type 2 diabetes who are not currently treated with insulin is 10 units (or 0.2 units/kg) once daily
  • Basaglar® may be administered at any time during the day
  • Basaglar® should be administered at the same time every day
  • Basaglar® is a basal insulin. See insulin dosing for more.
  • See converting between insulin brands and types for information on changing insulins

Other

  • Basaglar® should be clear and colorless

Storage

Unpunctured, refrigerated
  • Pens are good until expiration date on product
Unpunctured, room temp
  • Pens are good for 28 days
Punctured (in use)
  • Pens should be kept at room temperature (do not refrigerate)
  • Pens are good for 28 days

Lantus® (insulin glargine)

Dosage forms

Vial (100 units/ml)
  • 10 ml vial
SoloStar® Pen (100 units/ml)
  • 3 ml pen
  • Comes in package of 5 pens
  • Compatible with BD® pen needles

Pharmacokinetics

Onset of action
  • 1 - 3 hours
Duration of action
  • 24+ hours
Peak effect
  • No peak

Mixing

- DO NOT MIX with other insulins

Dosing

  • Dosage will vary by patient
  • The recommended starting dose of Lantus® in patients with type 2 diabetes who are not currently treated with insulin is 0.2 units/kg or up to 10 units once daily
  • Lantus® may be administered at any time during the day
  • Lantus® should be administered at the same time every day
  • Lantus® is a basal insulin. See insulin dosing for more.
  • See converting between insulin brands and types for information on changing insulins

Other

  • Lantus® should be clear and colorless

Storage

Unpunctured, refrigerated
  • Vials and pens are good until expiration date on product
Unpunctured, room temp
  • Vials and pens are good for 28 days
Punctured (in use)
  • Vials may be refrigerated or kept at room temperature
  • Pens should be kept at room temperature (do not refrigerate)
  • Vials and pens are good for 28 days

Studies


Levemir® (insulin detemir)

Dosage forms

Vial (100 units/ml)
  • 10 ml vial
FlexTouch® Pen (100 units/ml)
  • 3 ml pen
  • Comes in package of 5
  • FlexTouch® pen button maintains the same extension at all doses
  • Compatible with NovoFine, Novofine Plus, NovoTwist, and BD pen needles

Pharmacokinetics

Onset of action
  • 1 - 3 hours
Duration of action
  • 6 - 24 hours
  • Levemir's duration of action depends on the dose

Dose (units/kg) Duration (hours)
0.1 6
0.2 12
0.4 20
≥0.8 22 - 24
Peak effect
  • Levemir does not have a pronounced peak effect like NPH, but at lower doses, its duration of action is shorter and its waning action can create a peak and valley effect.
  • At doses of 0.2 units/kg, it's maximum effect occurs 3 - 4 hours after dosing
  • At doses of ≥ 0.4 units/kg, it's maximum effect occurs 8 - 12 hours after dosing

Mixing

- DO NOT MIX with other insulins

Dosing

  • Dosage will vary by patient
  • Levemir® may be dosed once- or twice-daily
  • Once-daily doses should be administered with the evening meal or at bedtime
  • With twice-daily dosing, the evening dose can be administered with the evening meal, at bedtime, or 12 hours after the morning dose
  • The recommended starting dose of Levemir® in type 2 diabetics is 10 Units (or 0.1-0.2 Units/kg) given once daily in the evening or divided into a twice-daily regimen
  • Levemir® is a basal insulin. See insulin dosing for more.
  • See converting between insulin brands and types for information on changing insulins

Other

  • Levemir® should be clear and colorless

Storage

Unpunctured, refrigerated
  • Vials and pens are good until expiration date on product
Unpunctured, room temp
  • Vials and pens are good for 42 days
Punctured (in use)
  • Vials may be refrigerated or kept at room temperature
  • Pens should be kept at room temperature (do not refrigerate)
  • VIals and pens are good for 42 days

Semglee® (insulin glargine)

Dosage forms

Vial (100 units/ml)
  • 10 ml vial
Pen (100 units/ml)
  • 3 ml pen
  • Comes in package of 3 or 5 pens
  • Compatible with BD® Ultra-Fine pen needles

Pharmacokinetics

Onset of action
  • 1 - 3 hours
Duration of action
  • 24+ hours
Peak effect
  • No peak

Mixing

- DO NOT MIX with other insulins

Dosing

  • Dosage will vary by patient
  • The recommended starting dose of Semglee® in patients with type 2 diabetes who are not currently treated with insulin is 0.2 units/kg or up to 10 units once daily
  • Semglee® may be administered at any time during the day
  • Semglee® should be administered at the same time every day
  • Semglee® is a basal insulin. See insulin dosing for more.
  • See converting between insulin brands and types for information on changing insulins

Other

  • Semglee® should be clear and colorless

Storage

Unpunctured, refrigerated
  • Vials and pens are good until expiration date on product
Unpunctured, room temp
  • Vials and pens are good for 28 days
Punctured (in use)
  • Vials may be refrigerated or kept at room temperature
  • Pens should be kept at room temperature (do not refrigerate)
  • Vials and pens are good for 28 days

Toujeo® (insulin glargine)

Dosage forms

Toujeo SoloStar® Pen (300 units/ml)
  • 1.5 ml pen
  • Comes in package of 3 pens
  • Max dose per injection is 80 units
  • Compatible with BD® Ultra-Fine pen needles
Toujeo Max® Pen (300 units/ml)
  • 3 ml pen
  • Comes in package of 2 pens
  • Max dose per injection is 160 units
  • Compatible with BD® Ultra-Fine pen needles

Pharmacokinetics

Onset of action
  • 6 hours
Duration of action
  • 24+ hours
  • Steady state is reached at ≥ 5 days
Peak effect
  • No peak

Mixing

- DO NOT MIX with other insulins

Dosing

  • Dosage will vary by patient
  • The recommended starting dose of Toujeo® in patients with type 2 diabetes who are not currently treated with insulin is 0.2 units/kg once daily
  • Toujeo® may be administered at any time during the day
  • Toujeo® should be administered at the same time every day
  • Toujeo® is a basal insulin. See insulin dosing for more.
  • In a multidose study, the glucose-lowering effect of Toujeo® was about 27% lower than that of an equivalent dose of Lantus®
  • See converting between insulin brands and types for information on changing insulins

Other

  • Toujeo® should be clear and colorless

Storage

Unpunctured, refrigerated
  • Pens are good until expiration date on product
Punctured (in use)
  • Pens should be kept at room temperature (do not refrigerate)
  • Pens are good for 56 days

Tresiba® (insulin degludec)

Dosage forms

FlexTouch® Pen
  • Comes in 2 strengths:
    • U-100 - 100 units/ml
    • U-200 - 200 units/ml
  • Pens contain 3 mls
  • U-100 comes in package of 5 pens
  • U-200 comes in package of 3 pens
  • Compatible with NovoFine, Novofine Plus, NovoTwist, and BD pen needles
Vial (100 units/ml)
  • 10 ml vial

Pharmacokinetics

Onset of action
  • 1 - 3 hours
Duration of action
  • 24+ hours
Peak effect
  • No peak

Mixing

- DO NOT MIX with other insulins

Dosing

  • Dosage will vary by patient
  • Tresiba is dosed once daily and may be given at any time during the day
  • The recommended starting dose of Tresiba in insulin-naïve type 2 diabetics is 10 units once daily
  • Tresiba is a basal insulin. See insulin dosing for more.
  • See converting between insulin brands and types for information on changing insulins
  • See Xultophy for information on Xultophy dosing

Other

  • Tresiba should be clear and colorless

Storage

Unpunctured, refrigerated
  • Pens and vials are good until expiration date on product
Unpunctured, room temp
  • Pens and vials are good for 56 days
Punctured (in use)
  • Pens and vials may be refrigerated or kept at room temperature
  • Pens and vials are good for 56 days

Studies




Humalog® Mix 75/25 | 75% insulin lispro protamine and 25% insulin lispro

Dosage forms

Vial (100 units/ml)
  • 10 ml vial
KwikPen® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5
  • Compatible with BD® pen needles

Pharmacokinetics

Onset of action
  • 10 - 30 minutes
Duration of action
  • up to 20 hours
Peak effect
  • 1 - 4 hours

Mixing

- DO NOT MIX with other insulins

Dosing

  • Insulin lispro is a rapid-acting insulin
  • Insulin lispro protamine is an intermediate-acting insulin that is formed by combining insulin lispro and protamine sulfate
  • Dosage will vary by patient
  • Dosage should be given within 15 minutes of a meal
  • See insulin dosing for more

Other

  • Humalog® Mix should be resuspended before use (see instructions with product)
  • Humalog® Mix should appear uniformly cloudy with no particulate matter after resuspending

Storage

Unpunctured, refrigerated
  • Vials and pens are good until expiration date on product
Unpunctured, room temp
  • Vials are good for 28 days
  • Pens are good for 10 days
Punctured (in use)
  • Vials may be refrigerated or kept at room temperature
  • Pens should be kept at room temperature (do not refrigerate)
  • Vials are good for 28 days
  • Pens are good for 10 days

Humalog® Mix 50/50 | 50% insulin lispro and 50% insulin lispro protamine

Dosage forms

Vial (100 units/ml)
  • 10 ml vial
KwikPen® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5
  • Compatible with BD® pen needles

Pharmacokinetics

Onset of action
  • 10 - 30 minutes
Duration of action
  • up to 20 hours
Peak effect
  • 1 - 4 hours

Mixing

- DO NOT MIX with other insulins

Dosing

  • Insulin lispro is a rapid-acting insulin
  • Insulin lispro protamine is an intermediate-acting insulin that is formed by combining insulin lispro and protamine sulfate
  • Dosage will vary by patient
  • Dosage should be given within 15 minutes of a meal
  • See insulin dosing for more

Other

  • Humalog® Mix should be resuspended before use (see instructions with product)
  • Humalog® Mix should appear uniformly cloudy with no particulate matter after resuspending

Storage

Unpunctured, refrigerated
  • Vials and pens are good until expiration date on product
Unpunctured, room temp
  • Vials are good for 28 days
  • Pens are good for 10 days
Punctured (in use)
  • Vials may be refrigerated or kept at room temperature
  • Pens should be kept at room temperature (do not refrigerate)
  • Vials are good for 28 days
  • Pens are good for 10 days

Humulin® 70/30 | 70% NPH and 30% regular insulin

Dosage forms

Vial (100 units/ml)
  • Comes in 3 ml and 10 ml vials
KwikPen® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5
  • Compatible with BD® pen needles

Pharmacokinetics

Onset of action
  • 30 - 60 minutes
Duration of action
  • up to 20 hours
Peak effect
  • 3 - 12 hours

Mixing

- DO NOT MIX with other insulins

Dosing

  • Regular insulin is a short-acting insulin
  • NPH is a intermediate-acting insulin
  • Doses should be given 30 - 45 minutes before a meal
  • See dosing 70/30 insulin and NPH dosing for more

Other

  • Humulin® 70/30 should be resuspended before use (see instructions with product)
  • Humulin® 70/30 should appear uniformly cloudy with no particulate matter after resuspending

Storage

Unpunctured, refrigerated
  • Vials and pens are good until expiration date on product
Unpunctured, room temp
  • Vials are good for 31 days
  • Pens are good for 10 days
Punctured (in use)
  • Vials may be refrigerated or kept at room temperature
  • Pens should be kept at room temperature (do not refrigerate)
  • Vials are good for 31 days
  • Pens are good for 10 days

Novolin® 70/30 | 70% NPH and 30% regular insulin

Dosage forms

Vial (100 units/ml)
  • 10 ml vial
FlexPen (100 units/ml)
  • 3 ml pen
  • Comes in carton with 5 pens
  • Compatible with NovoFine, Novofine Plus, NovoTwist, and BD pen needles

Pharmacokinetics

Onset of action
  • 30 - 60 minutes
Duration of action
  • up to 20 hours
Peak effect
  • 3 - 12 hours

Mixing

- DO NOT MIX with other insulins

Dosing

  • Regular insulin is a short-acting insulin
  • NPH is a intermediate-acting insulin
  • Doses should be given 30 - 45 minutes before a meal
  • See dosing 70/30 insulin and NPH dosing for more

Other

  • Novolin® 70/30 should be resuspended before use (see instructions with product)
  • Novolin® 70/30 should appear uniformly cloudy with no particulate matter after resuspending

Storage

Unpunctured, refrigerated
  • Vial and pens are good until expiration date on product
Unpunctured, room temp
  • Vials are good for 42 days
  • Pens are good for 28 days
Punctured (in use)
  • Vials and pens should be kept at room temperature (do not refrigerate)
  • Vials are good for 42 days
  • Pens are good for 28 days

Novolog® Mix 70/30 | 70% insulin aspart protamine and 30% insulin aspart

Dosage forms

Vial (100 units/ml)
  • 10 ml vial
FlexPen® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5
  • Compatible with NovoFine, Novofine Plus, NovoTwist, and BD pen needles

Pharmacokinetics

Onset of action
  • 10 - 30 minutes
Duration of action
  • up to 20 hours
Peak effect
  • 1 - 4 hours

Mixing

- DO NOT MIX with other insulins

Dosing

  • Insulin aspart is a rapid-acting insulin
  • Insulin aspart protamine is an intermediate-acting insulin that is formed by combining insulin aspart and protamine sulfate
  • Dosage will vary by patient
  • Doses should be given within 15 minutes of a meal
  • See insulin dosing for more

Other

  • Novolog® Mix should be resuspended before use (see instructions with product)
  • Novolog® Mix should appear uniformly cloudy with no particulate matter after resuspending

Storage

Unpunctured, refrigerated
  • Vials and pens are good until expiration date on product
Unpunctured, room temp
  • Vials are good for 28 days
  • Pens are good for 14 days
Punctured (in use)
  • Vials may be refrigerated or kept at room temperature
  • Pens should be kept at room temperature (do not refrigerate)
  • Vials are good for 28 days
  • Pens are good for 14 days

Ryzodeg® 70/30 | 70% insulin degludec and 30% insulin aspart

Dosage forms

FlexTouch® Pen (100 units/ml)
  • Pens contain 3 ml
  • Comes in package of 5 pens
  • Compatible with NovoFine, Novofine Plus, NovoTwist, and BD pen needles

Pharmacokinetics

Onset of action
  • 10 - 30 minutes
Duration of action
  • 24+ hours
Peak effect
  • 1/2 - 2 hours

Mixing

- DO NOT MIX with other insulins

Dosing

  • Insulin aspart is a rapid-acting insulin
  • Insulin degludec is a long-acting insulin
  • Dosage will vary by patient
  • May be given once or twice daily with any main meal
  • A rapid- or short-acting insulin may be given at other meals if needed
  • Doses should be given within 15 minutes of a meal
  • See insulin dosing for more

Other

  • Ryzodeg should be clear and colorless

Storage

Unpunctured, refrigerated
  • Pens are good until expiration date on product
Unpunctured, room temp
  • Pens are good for 28 days
Punctured (in use)
  • Pens should be kept at room temperature (do not refrigerate)
  • Pens are good for 28 days



Soliqua® (insulin glargine + lixisenatide)

Dosage forms

Pen (100/33)
  • 100 units/ml insulin glargine and 33 mcg/ml lixisenatide
  • Pens contain 3 ml
  • Comes in package of 5 pens
  • Pen window shows units of insulin glargine

Pharmacokinetics

NOTE: Parameters are for insulin glargine only
Onset of action
  • 1 - 3 hours
Duration of action
  • 24+ hours
Peak effect
  • No peak

Mixing

- DO NOT MIX with other insulins

Dosing

  • Insulin glargine is a long-acting insulin
  • Lixisenatide is a GLP-1 analog
  • Pen is dialed to units of insulin glargine. Minimum dose pen can deliver is 15 units and max is 60 units.
  • If inadequate control on < 30 units of basal insulin or lixisenatide, starting dose is 15 units once daily
  • If inadequate control on 30 - 60 units of basal insulin, starting dose is 30 units once daily
  • Titrate dose up or down by 2 - 4 units every week based on blood sugar goals
  • Max dose is 60 units
  • Administer once a day within the hour prior to the first meal of the day
  • See insulin dosing for more

Other

  • Soliqua should be clear and colorless to almost colorless

Storage

Unopened / Unused pens
  • Store in refrigerator
  • Good until expiration date on product
After first use
  • Pens should be kept at room temperature (do not refrigerate)
  • Pens are good for 28 days

Xultophy® (insulin degludec + liraglutide)

Dosage forms

Pen (100/3.6)
  • 100 units/ml insulin degludec and 3.6 mg/ml liraglutide
  • Pens contain 3 ml
  • Comes in package of 5 pens
  • Pen window shows units of insulin degludec
  • Compatible with NovoFine, Novofine Plus, NovoTwist, and BD pen needles

Pharmacokinetics

NOTE: Parameters are for insulin degludec only
Onset of action
  • 1 - 3 hours
Duration of action
  • 24+ hours
Peak effect
  • No peak

Mixing

- DO NOT MIX with other insulins

Dosing

  • Insulin degludec is a long-acting insulin
  • Liraglutide is a GLP-1 analog
  • Pen is dialed to units of insulin degludec. Minimum dose pen can deliver is 10 units and max is 50 units.
  • Recommended starting dose is 16 units once daily
  • Titrate dose up or down by 2 units every 3 - 4 days based on blood sugar goals
  • Max dose is 50 units
  • Administer at the same time each day with or without food
  • Patients who persistently require less than 16 units should discontinue Xultophy and use another product
  • See insulin dosing for more

Other

  • Xultophy should be clear and colorless

Storage

Unopened / Unused pens
  • Store in refrigerator
  • Good until expiration date on product
After first use
  • Store at room temperature or in a refrigerator
  • Good for 21 days



Insulin Reduced cost programs Free programs
Basaglar, Humalog,
Humulin N, Humulin R,
Humalog Mix 50/50, Humalog Mix 75/25
Lilly Insulin Value Program
  • Insurance: with and without
  • Cost: $35 for a month supply
  • Eligibility requirements: none
Lilly Cares program
  • Income < 400% of federal poverty level
  • U.S. legal resident
  • No insurance
Lantus, Toujeo, Admelog, Apidra Sanofi Insulin Value Savings Program
  • Insurance: without
  • Cost: $99/month for up to 10 packs of pens and/or vials
  • Eligibility requirements: none
Sanofi Patient Connection
  • Income < 400% of federal poverty level
  • U.S. legal resident
  • No insurance
Levemir, Tresiba, Novolog, Fiasp
Novolin N, Novolin R,
Novolin 70/30, Novolog Mix 70/30
My$99Insulin Program
  • Insurance: with and without
  • Cost: $99/month for up to 3 vials or 2 packs of pens
  • Eligibility requirements: none

Walmart (Novolin N, Novolin R, Novolin 70/30 only)
  • Insurance: with and without
  • Cost:
    • Novolin N - $25/vial and $43 for 5 pens
    • Novolin R - $25/vial
    • Novolin 70/30 - $25/vial and $43 for 5 pens
NovoCare Patient Assistance Program
  • Income < 400% of federal poverty level
  • U.S. legal resident
  • No insurance