LOOP DIURETIC DOSING









Bumetanide (Bumex®)

Dosage forms

Tablet
  • 0.5 mg
  • 1 mg
  • 2 mg

Dosing

Edema
  • Dosing: 0.5 - 2 mg once daily
  • Max: 10 mg/day
  • A second and third dose may be given at intervals of 4 -5 hours up to a maximum of 10 mg/day
  • May take without regard to food

Generic / Price

- YES/$

Other

  • Bumetanide 1 mg is approximately equivalent to furosemide 40 mg

Furosemide (Lasix®)

Dosage forms

Tablet
  • 20 mg
  • 40 mg
  • 80 mg

Dosing - Pediatric

Edema
  • Starting: 2 mg/kg given as a single dose
  • Maintenance: titrate to desired effect
  • Max: 6 mg/kg/dose
  • Increase dose in increments of 1 - 2 mg/kg/dose no sooner than 6 - 8 hours after previous dose
  • Some studies have shown decreased absorption when taken with food. Patients may want to take on an empty stomach. [2]

Dosing - Adults

Edema
  • Starting: 20 - 80 mg once daily
  • Maintenance: titrate to desired effect
  • Max: 600 mg/day
  • Increase dose in increments of 20 - 40 mg/dose
  • Second dose may be given 6 - 8 hours after previous dose
  • May be given once daily or in 2 divided doses
  • Some studies have shown decreased absorption when taken with food. Patients may want to take on an empty stomach. [2]
Hypertension
  • Starting: 40 mg twice a day
  • Maintenance: titrate to desired effect
  • Some studies have shown decreased absorption when taken with food. Patients may want to take on an empty stomach. [2]

Generic / Price

- YES/$

Other

  • Furosemide dosing varies widely depending on the severity of illness, drug tolerance, and medical condition being treated

Torsemide | Demadex® | Soaanz®

Dosage forms

Tablet (Demadex®)
  • 5 mg
  • 10 mg
  • 20 mg
  • 100 mg
Tablet (Soaanz®)
  • 20 mg
  • 40 mg
  • 60 mg

Dosing - Demadex

Congestive heart failure (CHF)
  • Starting: 10 - 20 mg once daily
  • Maintenance: titrate to desired effect
  • Max: 200 mg/day
  • When increasing dose, dose should be doubled
  • May take without regard to food
Chronic kidney failure
  • Starting: 20 mg once daily
  • Maintenance: titrate to desired effect
  • Max: 200 mg/day
  • When increasing dose, dose should be doubled
  • May take without regard to food
Liver cirrhosis
  • Starting: 5 - 10 mg once daily
  • Maintenance: titrate to desired effect
  • Max: 40 mg/day
  • When increasing dose, dose should be doubled
  • May take without regard to food
Hypertension
  • Starting: 5 mg once daily
  • Maintenance: 5 - 10 mg once daily
  • Max: 10 mg/day
  • May take without regard to food

Generic / Price

  • Demadex - YES/$
  • Soaanz - NO/$$$$

Other

  • Soaanz offers no benefit over generic torsemide. See Soaanz review for more.
  • Oral and intravenous doses are equivalent










Drug Peak effect Duration of effect
Furosemide 1 - 2 hours 6 - 8 hours
Bumetanide 1 - 2 hours 4 - 6 hours
Torsemide 1 - 2 hours 6 - 8 hours



Pricing legend
  • $ = 0 - $50
  • $$ = $51 - $100
  • $$$ = $101 - $150
  • $$$$ = > $150
  • Pricing based on one month of therapy at standard dosing in an adult
  • Pricing based on information from GoodRX.com®
  • Pricing may vary by region and availability