• Average baseline weight was 220 pounds (100kg)
  • Average BMI was 36
  • Dropout rate: lorcaserin - 44%; placebo - 51%
  • Reference [2]
Lorcaserin for weight loss
52-week, placebo-controlled trials
Lorcaserin 10 mg twice daily
(N=3098)
Placebo
(N=3038)
Average weight change -12.8 pounds
(-5.8kg)
-5.5 pounds
(-2.5kg)
Average % change in weight -5.8% -2.5%




  • Side effects that occurred in ≥ 2% of patients and at an incidence ≥ 2% more than placebo
  • Reference [2]
Side Effect Lorcaserin
(N=3195)
Placebo
(N=3185)
Headache 16.8% 10.1%
Dizziness 8.5% 3.8%
Nausea 8.3% 5.3%
Fatigue 7.2% 3.6%
Dry mouth 5.3% 2.3%