- ACRONYMS AND DEFINITIONS
- AASLD - American Association for the Study of Liver Disease
- HCV - Hepatitis C virus
- PI - Package Insert
- ULN - Upper Limit of Normal
- DRUGS IN CLASS
- Hepatitis C treatment
- Mavyret is part of a new generation of antiviral medications that are highly effective against hepatitis C
- Mavyret is a combination pill that contains 2 medications - glecaprevir and pibrentasvir
- See Hepatitis C treatment for a list of other HCV drugs
- MECHANISM OF ACTION
- Glecaprevir is HCV NS3/4A protease inhibitor
- HCV NS3/4A protease cleaves HCV-encoded polyprotein into the individual proteins NS3, NS4A, NS4B, NS5A, and NS5B. These proteins form a complex that is necessary for viral replication.
- Pibrentasvir is an inhibitor of the HCV NS5A protein which is essential for viral replication and virion assembly
- FDA-APPROVED INDICATIONS
- Mavyret is approved for the treatment of the following in adults and pediatric patients 12 years and older or weighing at least 99 lbs (45 kg):
- Treatment of HCV genotypes 1, 2, 3, 4, 5, and 6 - no cirrhosis or Child-Pugh A
- Treatment of HCV genotype 1 - in patients with no cirrhosis or Child-Pugh A who previously have been treated with a regimen containing an HCV NS5A inhibitor or an NS3/4A protease inhibitor, but not both
- Hepatitis C
- In trials, Mavyret was > 90% effective in eradicating HCV in all subtypes of disease for which it is indicated
- SIDE EFFECTS
- In trials, the incidence of side effects with Mavyret was similar to placebo
- The most common side effects reported were headache (13%), fatigue (11%), and nausea (8%)
- Side effects were similar in patients receiving Mavyret for 8, 12, and 16 weeks
- The type and severity of side effects in subjects with Child-Pugh A were comparable to those seen in subjects without cirrhosis
- Bilirubin elevations
- In trials, total bilirubin elevations > 2 X ULN were observed in 3.5% of Mavyret-treated patients and in 0% of placebo-treated patients
- The effects of Mavyret on bilirubin levels may be due to its inhibitory action on OATP1B1/B3 and UGT1A1
- Severe liver disease (Child-Pugh C)
- Coadministration with rifampin
- Coadministration with atazanavir
- Kidney disease
- No dose adjustment is necessary for patients with mild, moderate or severe renal impairment, including those on dialysis
- Liver disease
- Child-Pugh A: approved for use
- Child-Pugh B: not recommended
- Child-Pugh C: DO NOT USE
- Hepatitis B coinfection
- In October 2016, the FDA placed a boxed warning on all new hepatitis C drugs about the possible reactivation of hepatitis B infection in coinfected patients who are taking direct-acting antiviral hepatitis C drugs
- At the time of the warning, the FDA had identified 24 cases of hepatitis B reactivation in patients taking these drugs. Reactivation occurred in patients who were HBsAg positive and in those who were HBsAg negative and anti-HBc positive (see hepatitis B serology for more).
- The FDA recommends that providers check all patients for hepatitis B coinfection (HBsAg and anti-HBc) before starting therapy and that they monitor patients for reactivation during and after therapy
- See AASLD guidelines for HBV coinfected patients for more
- MONITORING THERAPY
- DRUG INTERACTIONS
- NOTE: The drug interactions presented here are NOT A COMPREHENSIVE LIST of all known interactions. Other interactions exist. The interactions below are meant to encompass commonly prescribed medications and/or interactions that are well-documented. Always consult your physician or pharmacist before taking medications concurrently. CLICK HERE for more information on drug interactions.
- HIGH ALERT INTERACTIONS
Glecaprevir and pibrentasvir
- See the Mavyret PI for a complete list of potential drug interactions
- Carbamazepine - DO NOT COMBINE. Carbamazepine may decrease plasma levels and efficacy.
- Phenytoin - DO NOT COMBINE. Phenytoin may decrease plasma levels and efficacy.
- Efavirenz - DO NOT COMBINE. Efavirenz may decrease plasma levels and efficacy.
- Ethinyl estradiol (OCPs, HRT) - DO NOT COMBINE. Concomitant therapy may increase the risk of ALT elevations.
- HIV medications (darunavir, lopinavir, ritonavir, atazanavir) - DO NOT COMBINE. May increase Mavyret exposure and lead to toxicity.
- Rifampin - DO NOT COMBINE. Rifampin may decrease plasma levels and efficacy.
- St. John's Wort - DO NOT COMBINE. St. John's Wort may decrease plasma levels and efficacy.
- Cyclosporine - Cyclosporine may raise Mavyret exposure. Do not combine in patients who require > 100 mg of cyclosporine a day.
- Dabigatran (Pradaxa®) - Mavyret may raise dabigatran levels. See dabigatran for information on dosing dabigatran with p-glycoprotein inhibitors.
- Digoxin - Mavyret may raise digoxin levels. Decrease digoxin dose by 50% when given with Mavyret.
- Warfarin - Mavyret may cause fluctuations in INR values in patients receiving warfarin. Monitor INR closely during concomitant therapy.
- Atorvastatin (Lipitor®) - DO NOT COMBINE. Atorvastatin exposure is increased raising the risk of myopathy.
- Lovastatin (Mevacor®) - DO NOT COMBINE. Lovastatin exposure is increased raising the risk of myopathy.
- Simvastatin (Zocor®) - DO NOT COMBINE. Simvastatin exposure is increased raising the risk of myopathy.
- Pravastatin (Pravachol®) - Pravastatin exposure is increased raising the risk of myopathy. Reduce pravastatin dose by 50%.
- Rosuvastatin (Crestor®) - Rosuvastatin exposure is increased raising the risk of myopathy. Rosuvastatin dose should not exceed 10 mg.
- Fluvastatin (Lescol®) - Fluvastatin exposure is increased raising the risk of myopathy. Use lowest approved dose of fluvastatin.
- Pitavastatin (Livalo®) - Pitavastatin exposure is increased raising the risk of myopathy. Use lowest approved dose of pitavastatin.
- METABOLISM AND ELIMINATION
- NOTE: Drugs can be metabolized by more than one enzyme. Drugs may be metabolized by an enzyme and inhibit/induce the enzyme at the same time. Drug transporters (ex. p-glycoprotein) can play a role in drug metabolism. Not all drug interactions are clinically significant. Consult your physician or pharmacist if you are taking medications together and are concerned about a possible interaction.
- P-glycoprotein - substrate and inhibitor
- BCRP - substrate and inhibitor
- OATP1B1/B3 - substrate and inhibitor
- CYP3A4 - weak inhibitor
- CYP1A2 - weak inhibitor
- UGT1A1 - weak inhibitor
- Dosage forms
- One tablet contains glecaprevir 100 mg and pibrentasvir 40 mg
- Three Mavyret tablets once daily with food
- Take with food. Food increases absorption.
|Treatment-naïve patients - HCV Genotype 1, 2, 3, 4, 5, and 6|
|No cirrhosis||Three Mavyret tablets once daily with food for 8 weeks|
|Child-Pugh A||Three Mavyret tablets once daily with food for 12 weeks|
|HCV GN||Previous treatment||No cirrhosis||Child-Pugh A|
|1||An NS5A inhibitor without prior treatment with an NS3/4A protease inhibitor||16 weeks||16 weeks|
|1||An NS3/4A protease inhibitor without prior treatment with an NS5A inhibitor||12 weeks||12 weeks|
|1, 2, 4, 5, 6||✝PRS||8 weeks||12 weeks|
|3||✝PRS||16 weeks||16 weeks|
|Liver or kidney transplant recipients|
|HCV GN||Previous treatment||Duration|
|1, 2, 3, 4, 5, 6||None||12 weeks|
|1||NS5A inhibitor-experienced without prior treatment with an NS3/4A protease inhibitor||16 weeks|
|3||PRS treatment-experienced✝||16 weeks|
- LONG TERM SAFETY
- Mavyret was FDA-approved in 2017
- There is no long-term safety data available
- GENERIC AVAILABILITY
- Possible generic:
NOTE: Drug companies typically file multiple patents on their drugs in order to protect them from competition. The patent expiration listed here is the date that the earliest patent on the drug expires (accounting for pediatric exclusivity). Because drug companies use numerous techniques to extend the life of their patents, it does not necessarily mean a generic will become available around this date.
- What is PMID?
- PI = Manufacturer's Package Insert
- 1 - Manufacturer's package insert