MEGLITINIDE DOSING









Nateglinide (Starlix®)

Dosage forms

Tablet
  • 60 mg
  • 120 mg

Dosing

Type 2 diabetes
  • Dosing: 120 mg three times a day before meals
  • Max: 120 mg three times a day before meals
  • 60 mg dose may be used in patients close to A1C goals
  • Take 1 - 30 minutes prior to a meal

Generic / Price

- YES/$$

Repaglinide (Prandin®)

Dosage forms

Tablet
  • 0.5 mg
  • 1 mg
  • 2 mg

Dosing

Type 2 diabetes
  • Starting
    • HgA1C < 8%
      • 0.5 mg before each meal
    • HgA1C ≥ 8%
      • 1 - 2 mg before each meal
  • Maintenance
    • 0.5 - 4 mg with each meal
    • Increase dose at intervals of ≥ 1 week
    • Do not exceed 16 mg/day
    • Increase dose by doubling current dose
    • May be given up to 4 times a day
    • Do not give dose if meal is skipped
    • Take within 30 minutes before meals

Generic / Price

- YES/$



PrandiMet® (repaglinide + metformin)

Dosage forms

Tablet
  • Repaglinide - Metformin
    • 1 mg - 500 mg
    • 2 mg - 500 mg

Dosing

Type 2 diabetes
  • Starting: 1/500 mg twice daily with meals
  • Max: repaglinide 10 mg/day; metformin 2500 mg/day
  • May be given two to three times a day
  • No more than 4 mg repaglinide or 1000 mg metformin should be taken per meal
  • Ideally taken 15 minutes prior to a meal, but can vary from 0 - 30 minutes

Generic / Price

- YES/$$$$

Other

  • If meal is skipped, do not take dose










Pricing legend
  • $ = 0 - $50
  • $$ = $51 - $100
  • $$$ = $101 - $150
  • $$$$ = > $150
  • Pricing based on one month of therapy at standard dosing in an adult
  • Pricing based on information from GoodRX.com®
  • Pricing may vary by region and availability