ORAL CONTRACEPTIVES


































  • Considered 2nd and 3rd generation. Norgestimate is converted to norgestrel (half-life 38 hours) and norelgestromin (half-life 18 hours)
  • References [1,9,Package insert]
PROGESTINS GROUPED BY GENERATION
First generation Second generation Third generation
  • Dienogest
  • Ethynodiol Diacetate
  • Norethindrone
  • Norethindrone Acetate
  • Levonorgestrel
  • Norgestimate
  • Norgestrel
  • Desogestrel
  • Norgestimate
PROGESTINS GROUPED BY STRUCTURE
Testosterone-related Progesterone-related Spironolactone-related
  • Desogestrel (half-life 38 hours)
  • Dienogest (half-life 11 hours)
  • Ethynodiol Diacetate
  • Levonorgestrel (half-life 24-29 hours)
  • Norethindrone (half-life 8-9 hours)
  • Norethindrone Acetate (half-life 7-8 hours)
  • Norgestimate
  • Norgestrel (half-life 38 hours)
  • Medroxyprogesterone
  • Megestrol acetate
  • Drospirenone (half-life 30 hours)






































































  • The expected pregnancy rate without emergency contraception was 5.5%
  • From PMID 20116841
Pregnancy rate
(Hours from intercourse to treatment)
Method 0 - 24 25 - 48 49 - 72 73 - 96 97 - 120
Ulipristal 30 mg 1.6%
(5/312)
2.1%
(7/329)
1.5%
(3/203)
0%
(0/63)
0%
(0/34)
Levonorgestrel 1.5 mg 3%
(10/337)
2.2%
(7/319)
2.6%
(5/196)
2.7%
(2/73)
3%
(1/33)