• Reference: Manufacturer's PI
Side effect Roflumilast 500 mcg once daily
(N=4438)
Placebo once daily
(N=4192)
Diarrhea 9.5% 2.7%
Weight decrease 7.5% 2.1%
Nausea 4.7% 1.4%
Headache 4.4% 2.1%
Back pain 3.2% 2.2%
Influenza 2.8% 2.7%
Insomnia 2.4% 1.0%
Dizziness 2.1% 1.1%
Decreased appetite 2.1% 0.4%