SGLT2 INHIBITOR DOSING









Canagliflozin (Invokana®)

Dosage forms

Tablet
  • 100 mg
  • 300 mg

Dosing

Type 2 diabetes
  • Starting: 100 mg once daily
  • Maintenance: 100 - 300 mg once daily
  • Max: 300 mg once daily
  • Take before first meal of the day
  • Consider stopping drug during a fasting event (e.g. acute illness) and for at least 3 days prior to surgery to lower risk of diabetic ketoacidosis

Generic / Price

- NO/$$$$

Dapagliflozin (Farxiga®)

Dosage forms

Tablet
  • 5 mg
  • 10 mg

Dosing



  • Reference: Manufacturer's PI
GFR Dosing recommendations
≥ 45 ml/min Glycemic control in type 2 diabetes
  • Starting: 5 mg once daily
  • Maintenance: 5 - 10 mg once daily
  • Maximum: 10 mg once daily
  • May take without regard to food
Heart failure / Chronic kidney disease
  • Dosing: 10 mg once daily
  • May take without regard to food
25 - 44 ml/min Glycemic control in type 2 diabetes
  • Dapagliflozin is not likely to improve glycemic control in this GFR range
Heart failure / Chronic kidney disease
  • Dosing: 10 mg once daily
  • May take without regard to food
< 25 ml/min
  • Initiation is not recommended, however patients may continue 10 mg orally once daily to reduce the risk of eGFR decline, end stage kidney disease, CVD death and hospitalization for heart failure.
Dialysis
  • Contraindicated

Generic / Price

- NO/$$$$

Empagliflozin (Jardiance®)

Dosage forms

Tablet
  • 10 mg
  • 25 mg

Dosing

Type 2 diabetes
  • Starting: 10 mg once daily
  • Maintenance: 10 - 25 mg once daily
  • Max: 25 mg once daily
  • Take in morning with or without food
  • Use for glycemic control is not recommended in patients with GFR < 30 ml/min
  • Consider stopping drug during a fasting event (e.g. acute illness) and for at least 3 days prior to surgery to lower risk of diabetic ketoacidosis
Heart failure with reduced EF
  • Dosing: 10 mg once daily
  • Take in morning with or without food
  • Has not been studied in heart failure patients with GFR < 20 ml/min
  • Consider stopping drug during a fasting event (e.g. acute illness) and for at least 3 days prior to surgery to lower risk of diabetic ketoacidosis

Generic / Price

- NO/$$$$

Ertugliflozin (Steglatro™)

Dosage forms

Tablet
  • 5 mg
  • 15 mg

Dosing

Type 2 diabetes
  • Starting: 5 mg once daily in the morning
  • Maintenance: 5 - 15 mg once daily in the morning
  • Max: 15 mg once daily in the morning
  • Take in morning with or without food
  • Consider stopping drug during a fasting event (e.g. acute illness) and for at least 4 days prior to surgery to lower risk of diabetic ketoacidosis

Generic / Price

- NO/$$$$



Invokamet® (canagliflozin + metformin)

Dosage forms

Tablet
  • Canagliflozin - Metformin
    • 50 mg - 500 mg
    • 50 mg - 1000 mg
    • 150 mg - 500 mg
    • 150 mg - 1000 mg

Dosing

Type 2 diabetes
  • Starting: 50/500 mg twice daily
  • Maintenance: 50/500 - 150/1000 mg twice daily
  • Max: 150/1000 mg twice daily
  • Take with food

Generic / Price

- NO/$$$$

Invokamet® XR (canagliflozin + metformin ER)

Dosage forms

Tablet, extended-release
  • Canagliflozin - Metformin ER
    • 50 mg - 500 mg
    • 50 mg - 1000 mg
    • 150 mg - 500 mg
    • 150 mg - 1000 mg

Dosing

Type 2 diabetes
  • Starting: 50/500 mg once daily
  • Maintenance: 50/500 - 300/2000 mg once daily
  • Max: 300/2000 mg once daily
  • Take with morning meal

Generic / Price

- NO/$$$$

Other

  • Swallow tablets whole. Do not crush, cut, or chew.

Segluromet® (ertugliflozin + metformin)

Dosage forms

Tablet
  • Ertugliflozin - Metformin
    • 2.5 mg - 500 mg
    • 2.5 mg - 1000 mg
    • 7.5 mg - 500 mg
    • 7.5 mg - 1000 mg

Dosing

Type 2 diabetes
  • Dosing: 2.5/500 mg - 7.5/1000 mg twice a day
  • Max: 7.5/1000 mg twice a day
  • Individualize starting dose based on patient's current regimen
  • Take with meals

Generic / Price

- NO/$$$$

Synjardy® (empagliflozin + metformin)

Dosage forms

Tablet
  • Empagliflozin - Metformin
    • 5 mg - 500 mg
    • 5 mg - 1000 mg
    • 12.5 mg - 500 mg
    • 12.5 mg - 1000 mg

Dosing

Type 2 diabetes
  • Starting: 5/500 mg twice daily
  • Maintenance: 5/500 - 12.5/1000 mg twice daily
  • Max: 12.5/1000 mg twice daily
  • Take with meals

Generic / Price

- NO/$$$$

Synjardy® XR (empagliflozin + metformin ER)

Dosage forms

Tablet, extended-release
  • Empagliflozin - Metformin ER
    • 5 mg - 1000 mg
    • 10 mg - 1000 mg
    • 12.5 mg - 1000 mg
    • 25 mg - 1000 mg

Dosing

Type 2 diabetes
  • Starting: 5/1000 mg once daily
  • Maintenance: 5/1000 - 25/2000 mg once daily
  • Max: 25/2000 mg once daily
  • Take with morning meal

Generic / Price

- NO/$$$$

Other

  • Swallow tablets whole. Do not crush, cut, or chew.

Xigduo™ XR (dapagliflozin + metformin ER)

Dosage forms

Tablet, extended-release
  • Dapagliflozin - Metformin ER
    • 5 mg - 500 mg
    • 5 mg - 1000 mg
    • 10 mg - 500 mg
    • 10 mg - 1000 mg

Dosing

Type 2 diabetes
  • Starting: 5/500 mg once daily
  • Maintenance: 5/500 - 10/2000 mg once daily
  • Max: 10/2000 mg once daily
  • Take with food in the morning

Generic / Price

- NO/$$$$

Other

  • Swallow tablets whole. Do not crush, cut, or chew.
  • Inactive ingredients may be eliminated in the feces as a soft, hydrated mass that may resemble the original tablet



Glyxambi® (empagliflozin + linagliptin)

Dosage forms

Tablet
  • Empagliflozin - Linagliptin
    • 10 mg - 5 mg
    • 25 mg - 5 mg

Dosing

Type 2 diabetes
  • Starting: 10/5 mg once daily
  • Maintenance: 10/5 - 25/5 mg once daily
  • Max: 25/5 mg once daily
  • May take without regard to food

Generic / Price

- NO/$$$$

Qtern® (dapagliflozin + saxagliptin)

Dosage forms

Tablet
  • Dapagliflozin - Saxagliptin
    • 5 mg - 5 mg
    • 10 mg - 5 mg

Dosing

Type 2 diabetes
  • Starting: 5/5 mg once daily
  • Maintenance: 5/5 - 10/5 mg once daily
  • Max: 10/5 mg once daily
  • Take in the morning
  • May take without regard to food

Generic / Price

- NO/$$$$

Other

  • Swallow whole. Do not crush, cut, or chew tablets.
  • Do not use in patients with GFR < 45 ml/min
  • Do not use with CYP3A4 strong inhibitors

Steglujan® (ertugliflozin + sitagliptin)

Dosage forms

Tablet
  • Ertugliflozin - Sitagliptin
    • 5 mg - 100 mg
    • 15 mg - 100 mg

Dosing

Type 2 diabetes
  • Starting: 5/100 mg once daily
  • Maintenance: 5/100 - 15/100 mg once daily
  • Max: 15/100 mg once daily
  • Take in the morning
  • May take without regard to food

Generic / Price

- NO/$$$$

Trijardy® XR (empagliflozin + linagliptin + metformin ER)

Dosage forms

Tablet, extended-release
  • Empagliflozin - Linagliptin - Metformin ER
    • 5 mg - 2.5 mg - 1000 mg
    • 10 mg - 5 mg - 1000 mg
    • 12.5 mg - 2.5 mg - 1000 mg
    • 25 mg - 5 mg - 1000 mg

Dosing

Type 2 diabetes
  • Starting:
    • For patients switching from metformin with or without linagliptin, use a dosage that gives a similar total daily dose of metformin and a total daily dose of empagliflozin 10 mg and linagliptin 5 mg
    • For patients switching from metformin and any regimen containing empagliflozin with or without linagliptin, use a dosage that gives a similar total daily dose of metformin, the same total daily dose of empagliflozin, and linagliptin 5 mg
  • Max: Empagliflozin 25 mg/day | Linagliptin 5 mg/day | Metformin ER 2000 mg/day
  • Take once daily with a meal in the morning

Generic / Price

- NO/$$$$

Other

  • Swallow tablets whole. Do not crush, cut, dissolve, or chew.
  • Incompletely dissolved tablets may be seen in the feces. Patients should report this finding to their healthcare provider, and the provider should assess their glycemic control.










Pricing legend
  • $ = 0 - $50
  • $$ = $51 - $100
  • $$$ = $101 - $150
  • $$$$ = > $150
  • Pricing based on one month of therapy at standard dosing in an adult
  • Pricing based on information from GoodRX.com®
  • Pricing may vary by region and availability

Patient Assistance Programs for SGLT2 Inhibitors
Drug Manufacturer Ships to PAP info Application
Canagliflozin (Invokana®, Invokamet®, Invokamet® XR) Johnson and Johnson Pharmacy Link Link
Dapagliflozin (Farxiga®, Qtern®, Xigduo XR®) AstraZeneca Patient or doctor Link Link
Empagliflozin (Jardiance®, Glyxambi®, Synjardy®, Synjardy® XR) Boehringer Ingelheim Patient Link Link
Ertugliflozin (Steglatro®, Steglujan®) Merck N/A N/A N/A