SIMEPREVIR (OLYSIO®)

























  • RBV = Ribavirin
  • PegIFN = Pegylated Interferon
  • All data is from first 12 weeks of treatment
  • See ribavirin and pegylated interferon for side effects associated with each medication
Side Effect Simeprevir + PegIFN + RBV
Placebo + PegIFN + RBV
Rash
(including photosensitivity)
28% 20%
Itching 22% 15%
Nausea 22% 18%
Muscle ache 16% 13%
Dyspnea
(shortness of breath)
12% 8%
Elevated alkaline phosphatase
(> 1.25 to ≤ X 2.5 ULN)
3% 1%
Elevated bilirubin
(> 1.1 to ≤ 1.5 X ULN)
(> 1.5 to ≤ 2.5 X ULN)
(> 2.5 to ≤ 5 X ULN)

27%
18%
4%

15%
9%
2%