SULFONYLUREA DOSING








Glimepiride (Amaryl®)

Dosage forms

Tablet
  • 1 mg
  • 2 mg
  • 4 mg

Dosing

Type 2 diabetes
  • Starting: 1 - 2 mg once daily
  • Maintenance: 2 - 8 mg once daily
  • Max: 8 mg once daily
  • Increase dose in increments of 1 - 2 mg a day at intervals of 1 - 2 weeks
  • For patients at increased risk of hypoglycemia (e.g. kidney disease, elderly), starting dose should be 1 mg
  • Tablets are scored and may be cut in two
  • Take with first main meal of the day
Kidney disease
  • CrCl < 90 ml/min: exposure is increased. Use a starting dose of 1 mg once daily and titrate slowly.
Liver disease
  • Has not been studied. Use caution.

Generic / Price

- YES/$

Glipizide (Glucotrol®)

Dosage forms

Tablet
  • 5 mg
  • 10 mg

Dosing

Type 2 diabetes
  • Starting: 5 mg once daily
  • Maintenance: 10 - 20 mg/day
  • Max: 40 mg/day
  • Increase dose in increments of 2.5 - 5 mg a day every several days
  • Doses above 15 mg a day should be given in 2 divided doses
  • For patients at increased risk of hypoglycemia (e.g. kidney disease, elderly), starting dose should be 2.5 mg
  • Tablets are scored and may be cut in two
  • Take 30 minutes before a meal
Kidney disease
  • Exposure is increased. Consider a starting dose of 2.5 mg and titrate slowly.
Liver disease
  • Exposure may be increased. Consider a starting dose of 2.5 mg and titrate slowly.

Generic / Price

- YES/$

Glipizide (Glucotrol XL®)

Dosage forms

Tablet, extended-release
  • 2.5 mg
  • 5 mg
  • 10 mg

Dosing

Type 2 diabetes
  • Starting: 5 mg once daily
  • Maintenance: 5 - 10 mg once daily
  • Max: 20 mg/day
  • Increase dose at intervals of ≥ 7 days
  • For patients at increased risk of hypoglycemia (e.g. kidney disease, elderly), a starting dose of 2.5 mg may be appropriate
  • Do not cut, chew, or divide tablets
  • Take with first major meal of the day
Kidney disease
  • Exposure is increased. Consider a starting dose of 2.5 mg and titrate slowly.
Liver disease
  • Exposure may be increased. Consider a starting dose of 2.5 mg and titrate slowly.

Generic / Price

- YES/$

Glyburide (Micronase®)

Dosage forms

Tablet
  • 1.25 mg
  • 2.5 mg
  • 5 mg

Dosing

Type 2 diabetes
  • Starting: 2.5 - 5 mg once daily
  • Maintenance: 2.5 - 20 mg/day
  • Max: 20 mg/day
  • May be given once daily or in 2 divided doses
  • Increase dose in increments of 2.5 mg a day at weekly intervals
  • Doses > 10 mg a day may have a better response with twice daily dosing
  • For patients at increased risk of hypoglycemia (e.g. kidney disease, elderly), a starting dose of 1.25 mg may be appropriate
  • Tablets are scored and may be cut in two
  • Take with a meal
Kidney disease
  • Exposure may be increased. Use a lower starting dose and titrate slowly.
Liver disease
  • Exposure may be increased. Use a lower starting dose and titrate slowly.

Generic / Price

- YES/$

Glyburide (Diabeta®)

Dosage forms

Tablet
  • 1.25 mg
  • 2.5 mg
  • 5 mg

Dosing

Type 2 diabetes
  • Starting: 2.5 - 5 mg once daily
  • Maintenance: 2.5 - 20 mg/day
  • Max: 20 mg/day
  • May be given once daily or in 2 divided doses
  • Increase dose in increments of 2.5 mg a day at weekly intervals
  • Doses > 10 mg a day may have a better response with twice daily dosing
  • For patients at increased risk of hypoglycemia (e.g. kidney disease, elderly), a starting dose of 1.25 mg may be appropriate
  • Tablets are scored and may be cut in two
  • Take with a meal
Kidney disease
  • Exposure may be increased. Use a lower starting dose and titrate slowly.
Liver disease
  • Exposure may be increased. Use a lower starting dose and titrate slowly.

Generic / Price

- YES/?

Glyburide (Glynase® PresTab®)

Dosage forms

Tablet
  • 1.5 mg
  • 3 mg
  • 6 mg

Dosing

Type 2 diabetes
  • Starting: 1.5 - 3 mg once daily
  • Maintenance: 1.5 - 12 mg/day
  • Max: 12 mg/day
  • May be given once daily or in 2 divided doses
  • Increase dose in increments of 1.5 mg a day at weekly intervals
  • Doses > 6 mg a day may have a better response with twice daily dosing
  • For patients at increased risk of hypoglycemia (e.g. kidney disease, elderly), a starting dose of 0.75 mg may be appropriate
  • Tablets are scored and may be cut in two
  • Take with a meal
Kidney disease
  • Exposure may be increased. Use a lower starting dose and titrate slowly.
Liver disease
  • Exposure may be increased. Use a lower starting dose and titrate slowly.

Generic / Price

- YES/$

Glucovance® (glyburide + metformin)

Dosage forms

Tablet
  • Glyburide - Metformin
    • 1.25 mg - 250 mg
    • 2.5 mg - 500 mg
    • 5 mg - 500 mg

Dosing

Type 2 diabetes
  • Starting: 1.25/250 mg once or twice daily with meals
  • Max: glyburide 20 mg/day; metformin 2000 mg/day
  • Increase dose in increments of 1.25/250 mg/day at intervals of 2 weeks
  • Take with meals

Generic / Price

- YES/$

Metaglip® (glipizide + metformin)

Dosage forms

Tablet
  • Glipizide - Metformin
    • 2.5 mg - 250 mg
    • 2.5 mg - 500 mg
    • 5 mg - 500 mg

Dosing

Type 2 diabetes
  • Starting: 2.5/250 - 2.5/500 mg once or twice daily with meals
  • Max: glipizide 20 mg/day; metformin 2000 mg/day
  • Increase dose in increments of 2.5/250 mg/day at intervals of 2 weeks
  • Take with meals

Generic / Price

- YES/$

Duetact® (pioglitazone + glimepiride)

Dosage forms

Tablet
  • Pioglitazone - Glimepiride
    • 30 mg - 2 mg
    • 30 mg - 4 mg

Dosing

Type 2 diabetes
  • Starting: 30/2 - 30/4 mg once daily
  • Max: 30/4 mg once daily
  • Titrate to effect
  • Take with first main meal

Generic / Price

- YES/$$$







Pricing legend
  • $ = 0 - $50
  • $$ = $51 - $100
  • $$$ = $101 - $150
  • $$$$ = > $150
  • Pricing based on one month of therapy at standard dosing in an adult
  • Pricing based on information from GoodRX.com®
  • Pricing may vary by region and availability