THIAZIDE DIURETIC DOSING









Chlorothiazide (Diuril®)

Dosage forms

Tablet
  • 250 mg
  • 500 mg
Suspension
  • 250 mg/5 ml
  • Comes in 237 ml bottle

Dosing - Adults

Hypertension
  • Starting: 500 - 1000 mg/day
  • Maintenance: 500 - 1500 mg/day
  • Max: 2000 mg/day
  • May be given in one or two divided doses
  • May take without regard to food
Edema
  • 500 - 1000 mg given 1 - 2 times a day
  • Max: 2000 mg/day
  • May take without regard to food

Dosing - Pediatric

Hypertension and diuresis (< 2 years)
  • Dosing: 10 - 20 mg/kg/day (max 375 mg/day)
  • May be given once daily or in two divided doses
  • In infants < 6 months of age, doses up to 30 mg/kg/day in two divided doses may be required
  • May take without regard to food
Hypertension and diuresis (2 - 12 years)
  • Dosing: 10 - 20 mg/kg/day (max 1000 mg/day)
  • May be given once daily or in two divided doses
  • May take without regard to food

Generic / Price

  • Tablet - YES/$
  • Suspension - NO/$$

Other

  • Store suspension at room temperature

Chlorthalidone (Thalitone®)

Dosage forms

Tablet
  • 15 mg
  • 25 mg
  • 50 mg

Dosing - Adults

Hypertension
  • Starting: 12.5 - 25 mg once daily
  • Maintenance: 12.5 - 100 mg once daily
  • Max: 100 mg/day
  • Take with food
Edema
  • Starting: 50 - 100 mg once daily or every other day
  • Max: 200 mg/day
  • Take with food

Dosing - Pediatric

Hypertension
  • Starting: 0.3 mg/kg once daily
  • Max: 2 mg/kg (max 50 mg) once daily
  • AAP recommended dosing [2]
  • Take with food

Generic / Price

- YES/$

Other

  • In hypertension trials, doses of 12.5 - 25 mg/day were typically used
  • In general, a 12.5mg dose of chlorthalidone is equivalent to 25mg of hydrochlorothiazide. See HCTZ vs Chlorthalidone for more.
  • Doses above 50mg/day are rarely used and may lead to significant hypokalemia

Hydrochlorothiazide (HCTZ)

Dosage forms

Tablet
  • 12.5 mg
  • 25 mg
  • 50 mg
Capsule
  • 12.5 mg

Dosing - Adults

Hypertension
  • Starting: 25 mg/day (monotherapy)
  • Maintenance: 25 - 50 mg/day
  • Max: 50 mg/day
  • May be given in one or two divided doses
  • May take without regard to food
Edema
  • Maintenance: 25 - 100 mg/day
  • Max: 100 mg/day
  • May be given in one or two divided doses
  • May take without regard to food

Dosing - Pediatric

Hypertension and diuresis (< 2 years)
  • Dosing: 1 - 2 mg/kg/day (max 37.5 mg/day)
  • May be given once daily or in two divided doses
  • In infants < 6 months of age, doses up to 3 mg/kg/day in two divided doses may be required
  • May take without regard to food
Hypertension and diuresis (2 - 12 years)
  • Dosing: 1 - 2 mg/kg/day (max 100 mg/day)
  • May be given once daily or in two divided doses
  • May take without regard to food

Generic / Price

- YES/$

Other

  • A starting dose of 12.5 mg may be appropriate when adding to other medications (ex. ACE inhibitors, ARBs etc.)
  • Doses above 50 mg/day are rarely used

Indapamide (Lozol®)

Dosage forms

Tablet
  • 1.25 mg
  • 2.5 mg

Dosing

Hypertension
  • Starting: 1.25 mg once daily
  • Maintenance: 1.25 - 5 mg once daily
  • Max: 5 mg/day
  • May take without regard to food
Edema
  • Starting: 2.5 mg once daily
  • Maintenance: 2.5 - 5 mg once daily
  • Max: 5 mg/day
  • May take without regard to food

Generic / Price

- YES/$

Metolazone (Zaroxolyn®)

Dosage forms

Tablet
  • 2.5 mg
  • 5 mg
  • 10 mg

Dosing

Hypertension
  • Typical range: 2.5 - 5 mg once daily
  • Max: 20 mg/day
  • May take without regard to food
Edema
  • Typical range: 5 - 20 mg once daily
  • Max: 20 mg/day
  • May take without regard to food

Generic / Price

- YES/$

Other




Accuretic® (quinapril + HCTZ)

Dosage forms

Tablet
  • Quinapril - HCTZ
    • 10 mg - 12.5 mg
    • 20 mg - 12.5 mg
    • 20 mg - 25 mg

Dosing

Hypertension
  • Dosing: 10/12.5 mg - 40/25 mg once daily
  • Max: 40/25 mg once daily
  • Increase dose at intervals of 2 - 3 weeks
  • May take without regard to food

Generic / Price

- YES/$

Capozide® (captopril + HCTZ)

Dosage forms

Tablet
  • Captopril - HCTZ
    • 25 mg - 15 mg
    • 25 mg - 25 mg
    • 50 mg - 15 mg
    • 50 mg - 25 mg

Dosing

Hypertension
  • Dosing: HCTZ 25 - 50 mg/day; Captopril 25 - 150 mg/day
  • May be given once daily or in divided doses
  • Take one hour before meals

Generic / Price

- YES/$

Lotensin HCT® (benazepril + HCTZ)

Dosage forms

Tablet
  • Benazepril - HCTZ
    • 5 mg - 6.25 mg
    • 10 mg - 12.5 mg
    • 20 mg - 12.5 mg
    • 20 mg - 25 mg

Dosing

Hypertension
  • Starting: 10/12.5 mg once daily
  • Maintenance: 5/6.25 - 20/25 mg once daily
  • Max: 20/25 mg once daily
  • Increase dose at intervals of every 2 - 3 weeks
  • May take without regard to food

Generic / Price

- YES/$

Monopril HCT® (fosinopril + HCTZ)

Dosage forms

Tablet
  • Fosinopril - HCTZ
    • 10 mg - 12.5 mg
    • 20 mg - 12.5 mg

Dosing

Hypertension
  • Dosing: HCTZ 12.5 - 50 mg once daily; Fosinopril 10 - 80 mg once daily
  • In trials, the maximum dose used was 40/37.5 mg once daily
  • May take without regard to food

Generic / Price

- YES/$

Other

  • On average, the effect of the combination of 10 mg of fosinopril with 12.5 mg of HCTZ was similar to the effect seen with monotherapy using either 40 mg of fosinopril or 37.5 mg of HCTZ

Uniretic® (moexipril + HCTZ)

Dosage forms

Tablet
  • Moexipril - HCTZ
    • 7.5 mg - 12.5 mg
    • 15 mg - 12.5 mg
    • 15 mg - 25 mg

Dosing

Hypertension
  • Dosing: HCTZ 12.5 - 50 mg/day; Moexipril 7.5 - 30 mg/day
  • May be given once daily or in divided doses
  • Take one hour before a meal

Generic / Price

- YES/$

Vaseretic® (enalapril + HCTZ)

Dosage forms

Tablet
  • Enalapril - HCTZ
    • 5 mg - 12.5 mg
    • 10 mg - 25 mg

Dosing

Hypertension
  • Starting: 10/25 mg/day given once daily or in two divided doses
  • Max: 20/50 mg/day
  • Increase dose at intervals of 2 - 3 weeks
  • May take without regard to food

Generic / Price

- YES/$

Zestoretic® | Prinzide® (lisinopril + HCTZ)

Dosage forms

Tablet
  • Lisinopril - HCTZ
    • 10 mg - 12.5 mg
    • 20 mg - 12.5 mg
    • 20 mg - 25 mg

Dosing

Hypertension
  • Dosing: HCTZ 6.25 - 50 mg/day | Lisinopril 10 - 80 mg/day
  • Typically dosed once daily
  • Increase dose at intervals of 2 - 3 weeks
  • May take without regard to food

Generic / Price

- YES/$



Atacand HCT® (candesartan + HCTZ)

Dosage forms

Tablet
  • Candesartan - HCTZ
    • 16 mg - 12.5 mg
    • 32 mg - 12.5 mg
    • 32 mg - 25 mg

Dosing

Hypertension
  • Dosing: HCTZ 12.5 - 50 mg/day | Candesartan 8 - 32 mg/day
  • May be given once daily or divided into two doses
  • May take without regard to food

Generic / Price

- YES/$-$$

Other

  • Maximal effect seen within 4 weeks

Avalide® (irbesartan + HCTZ)

Dosage forms

Tablet
  • Irbesartan - HCTZ
    • 150 mg - 12.5 mg
    • 300 mg - 12.5 mg

Dosing

Hypertension
  • Starting: 150/12.5 mg once daily
  • Max: 300/25 mg once daily
  • Titrate dose at intervals of 1 - 2 weeks
  • May take without regard to food

Generic / Price

- YES/$

Benicar HCT® (olmesartan + HCTZ)

Dosage forms

Tablet
  • Olmesartan - HCTZ
    • 20 mg - 12.5 mg
    • 40 mg - 12.5 mg
    • 40 mg - 25 mg

Dosing

Hypertension
  • Starting: 20/12.5 - 40/12.5 mg once daily
  • Max: 40/25 mg once daily
  • May take without regard to food

Generic / Price

- YES/$

Diovan HCT® (valsartan + HCTZ)

Dosage forms

Tablet
  • Valsartan - HCTZ
    • 80 mg - 12.5 mg
    • 160 mg - 12.5 mg
    • 160 mg - 25 mg
    • 320 mg - 12.5 mg
    • 320 mg - 25 mg

Dosing

Hypertension
  • Starting: 160/12.5 mg once daily
  • Max: 320/25 mg once daily
  • Titrate dose at intervals of 1 - 2 weeks
  • May take without regard to food

Generic / Price

- YES/$

Other

  • Maximum effect seen within 2 - 4 weeks

Edarbyclor® (azilsartan + chlorthalidone)

Dosage forms

Tablet
  • Azilsartan - Chlorthalidone
    • 40 mg - 12.5 mg
    • 40 mg - 25 mg

Dosing

Hypertension
  • Starting: 40/12.5 mg once daily
  • Max: 40/25 mg once daily
  • Increase dose if needed after 2 - 4 weeks
  • May take without regard to food

Generic / Price

- NO/$$$$

Other

  • Most of the antihypertensive effect is seen within 1 - 2 weeks

Hyzaar® (losartan + HCTZ)

Dosage forms

Tablet
  • Losartan - HCTZ
    • 50 mg - 12.5 mg
    • 100 mg - 12.5 mg
    • 100 mg - 25 mg

Dosing

Hypertension
  • Starting: 50/12.5 mg once daily
  • Max: 100/25 mg once daily
  • Increase dose at intervals of 3 weeks
  • May take without regard to food
Hypertension with LVH to reduce the risk of stroke
  • Starting: 50/12.5 mg once daily
  • Max: 100/25 mg once daily
  • May take without regard to food

Generic / Price

- YES/$

Micardis HCT® (telmisartan + HCTZ)

Dosage forms

Tablet
  • Telmisartan - HCTZ
    • 40 mg - 12.5 mg
    • 80 mg - 12.5 mg
    • 80 mg - 25 mg
    • Comes in sealed blister pack of 30 tablets

Dosing

Hypertension
  • Starting: 80/12.5 mg once daily
  • Max: 160/25 mg once daily
  • Titrate dose at intervals of 2 - 4 weeks
  • May take without regard to food

Generic / Price

- YES/$

Other

  • Do not remove tablet from blister pack until ready to take



Corzide® (nadolol + Bendroflumethiazide)

Dosage forms

Tablet
  • Nadolol - Bendroflumethiazide
    • 40 mg - 5 mg
    • 80 mg - 5 mg

Dosing

Hypertension
  • Starting: 40/5 mg once daily
  • Maintenance: 40/5 - 80/5 mg once daily
  • May take without regard to food

Generic / Price

- YES/$$

Dutoprol® (metoprolol succinate ER + HCTZ)

Dosage forms

Tablet
  • Metoprolol - HCTZ
    • 25 mg - 12.5 mg
    • 50 mg - 12.5 mg
    • 100 mg - 12.5 mg

Dosing

Hypertension
  • Starting: 25 mg/12.5 mg once daily
  • Maintenance: 25 mg/12.5 mg - 200 mg/25 mg once daily
  • Max: 200 mg/25 mg once daily
  • Increase dose at intervals of 2 weeks
  • May take without regard to food

Generic / Price

- NO/$$$$

Inderide® (propranolol IR + HCTZ)

Dosage forms

Tablet
  • Propranolol - HCTZ
    • 40 mg - 25 mg
    • 80 mg - 25 mg

Dosing

Hypertension
  • Starting: 40 mg/25 mg twice a day
  • Maintenance: 40 mg/25 mg - 80 mg/25 mg twice a day
  • Max: 80 mg/25 mg twice a day
  • May take without regard to food

Generic / Price

- YES/$

Lopressor HCT® (metoprolol tartrate IR + HCTZ)

Dosage forms

Tablet
  • Metoprolol - HCTZ
    • 50 mg - 25 mg
    • 100 mg - 25 mg
    • 100 mg - 50 mg

Dosing

Hypertension
  • Dosing: Metoprolol may be dosed up to 200 mg/day. HCTZ may be dosed up to 50 mg/day. Daily dose may be given once daily or divided and given twice a day.
  • Metoprolol doses of ≤ 100 mg/day may be more effective if given in divided doses
  • Take with or immediately following a meal

Generic / Price

- YES/$

Tenoretic® (atenolol + chlorthalidone)

Dosage forms

Tablet
  • Atenolol - Chlorthalidone
    • 50 mg - 25 mg
    • 100 mg - 25 mg

Dosing

Hypertension
  • Starting: 50 mg/25 mg once daily
  • Maintenance: 50 mg/25 mg - 100 mg/25 mg once daily
  • May take without regard to food

Generic / Price

- YES/$

Ziac® (bisoprolol + HCTZ)

Dosage forms

Tablet
  • Bisoprolol - HCTZ
    • 2.5 mg - 6.25 mg
    • 5 mg - 6.25 mg
    • 10 mg - 6.25 mg

Dosing

Hypertension
  • Starting: 2.5 mg/6.25 mg once daily
  • Maintenance: 2.5 mg/6.25 mg - 20 mg/12.5 mg once daily
  • Max: 20 mg/12.5 mg once daily
  • Titrate dose at intervals of 14 days
  • May take without regard to food

Generic / Price

- YES/$



Dyazide® (HCTZ + triamterene)

Dosage forms

Capsule
  • HCTZ - Triamterene
    • 25 mg - 37.5 mg

Dosing

Hypertension or Edema
  • Dosing: 25/37.5 - 50/75 mg once daily
  • Max: 50/75 mg once daily
  • May take without regard to food

Generic / Price

- YES/$

Other

  • Triamterene helps prevent potassium loss from HCTZ but has no significant effect on blood pressure
  • See ENaC inhibitors for more

Maxzide® (HCTZ + triamterene)

Dosage forms

Tablet
  • HCTZ - Triamterene
    • 25 mg - 37.5 mg
    • 50 mg - 75 mg

Dosing

Hypertension or Edema
  • Dosing: 25/37.5 - 50/75 mg once daily
  • Max: 50/75 mg once daily
  • May take without regard to food

Generic / Price

- YES/$

Other

  • Triamterene helps prevent potassium loss from HCTZ but has no significant effect on blood pressure
  • See ENaC inhibitors for more

Moduretic® (HCTZ + amiloride)

Dosage forms

Tablet
  • Amiloride - HCTZ
    • 5 mg - 50 mg

Dosing

Hypertension or Edema
  • Dosing: 5/50 mg - 10/100 mg/day
  • May be given once daily or in divided doses
  • Take with food

Generic / Price

- YES/$

Other

  • Amiloride helps prevent potassium loss from HCTZ but has no significant effect on blood pressure
  • See ENaC inhibitors for more



Aldactazide® (HCTZ + spironolactone)

Dosage forms

Tablet
  • HCTZ - Spironolactone
    • 25 mg - 25 mg
    • 50 mg - 50 mg

Dosing

Hypertension
  • Dosing: 25/25 mg - 100/100 mg/day
  • May be given once daily or in divided doses
  • Food may increase the absorption of spironolactone. Manufacturer makes no specific recommendation.
Edema
  • Dosing: 25/25 mg - 200/200 mg/day
  • May be given once daily or in divided doses
  • Food may increase the absorption of spironolactone. Manufacturer makes no specific recommendation.

Generic / Price

  • 25/25 mg dose - YES/$
  • 50/50 mg dose - NO/$$$$



Aldoril® (methyldopa + HCTZ)

Dosage forms

Tablet
  • Methyldopa - HCTZ
    • 250 mg - 15 mg
    • 250 mg - 25 mg

Dosing

Hypertension
  • Starting: 250/15 mg two to three times a day OR 250/25 mg twice a day
  • Max: Methyldopa - 3000 mg/day; HCTZ 50 mg/day
  • May take without regard to food

Generic / Price

- YES/$$

Clorpres® (clonidine + chlorthalidone)

Dosage forms

Tablet
  • Clonidine - Chlorthalidone
    • 0.1 mg - 15 mg
    • 0.2 mg - 15 mg
    • 0.3 mg - 15 mg

Dosing

Hypertension
  • Dosing: 0.1/15 - 0.6/30 mg/day
  • Max: 0.6/30 mg/day
  • May be given once daily or in 2 divided doses
  • Chlorthalidone should be taken with food

Generic / Price

- NO/$$$



Tekturna HCT® (aliskiren + HCTZ)

Dosage forms

Tablet
  • Aliskiren - HCTZ
    • 150 mg - 12.5 mg
    • 150 mg - 25 mg
    • 300 mg - 12.5 mg
    • 300 mg - 25 mg

Dosing

Hypertension
  • Starting: 150/12.5 mg once daily
  • Maintenance: 150/12.5 - 300/25 mg once daily
  • Max: 300/25 mg once daily
  • The antihypertensive effect is largely manifested within 1 week with maximal effect seen within 4 weeks
  • Patients should establish a routine pattern for taking Tekturna HCT with regard to meals. High-fat meals decrease absorption substantially.

Generic / Price

- NO/$$$$



Exforge HCT® (amlodipine + valsartan + HCTZ)

Dosage forms

Tablet
  • Amlodipine - Valsartan - HCTZ
    • 5 mg - 160 mg - 12.5 mg
    • 5 mg - 160 mg - 25 mg
    • 10 mg - 160 mg - 12.5 mg
    • 10 mg - 160 mg - 25 mg
    • 10 mg - 320 mg - 25 mg

Dosing

Hypertension
  • Starting: 5/160/12.5 once daily
  • Maintenance: 5/160/12.5 mg - 10/320/25 mg once daily
  • Max: 10/320/25 mg once daily
  • Titrate dose at intervals of 2 weeks
  • Full antihypertensive effect is seen after 2 weeks
  • May take without regard to food

Generic / Price

- YES/$-$$

Tribenzor® (amlodipine + olmesartan + HCTZ)

Dosage forms

Tablet
  • Amlodipine - Olmesartan - HCTZ
    • 5 mg - 20 mg - 12.5 mg
    • 5 mg - 40 mg - 12.5 mg
    • 5 mg - 40 mg - 25 mg
    • 10 mg - 40 mg - 12.5 mg
    • 10 mg - 40 mg - 25 mg

Dosing

Hypertension
  • Starting: 5/20/12.5 mg once daily
  • Maintenance: 5/20/12.5 mg - 10/40/25 mg once daily
  • Max: 10/40/25 mg once daily
  • Titrate dose at intervals of 2 weeks
  • May take without regard to food

Generic / Price

- YES/$$










Pricing legend
  • $ = 0 - $50
  • $$ = $51 - $100
  • $$$ = $101 - $150
  • $$$$ = > $151
  • Pricing based on one month of therapy at standard dosing in an adult
  • Pricing based on information from GoodRX.com®
  • Pricing may vary by region and availability