APPETITE SUPPRESSANT DOSING

Drug	Dosage form	Dosing	Generic/Price	Food / Other
Benzphetamine Didrex®	Tablet 50 mg	Weight loss Starting: 25 - 50 mg once daily Maintenance: 25 - 50 mg one to three times a day Max: 150 mg/day See precautions for dosing in kidney and liver disease	YES/$$	FOOD Take midmorning OTHER DEA Schedule III Tablets are scored so they may be cut in two

Drug	Dosage form	Dosing	Generic/Price	Food / Other
Diethylpropion immediate-release Tenuate®	Tablet 25 mg	Weight loss Dosing: 25 mg three times a day Max: 100 mg/day A midevening dose may be added to overcome night hunger See precautions for dosing in kidney and liver disease	YES/$	FOOD Take one hour before meals OTHER DEA Schedule IV Usual starting dose is 25 mg three times a day before meals May take a fourth dose midevening to overcome night hunger

Drug	Dosage form	Dosing	Generic/Price	Food / Other
Diethylpropion extended-release Tenuate Dospan®	Tablet, extended-release 75 mg	Weight loss Dosing: 75 mg once daily Max: 75 mg once daily See precautions for dosing in kidney and liver disease	YES/$	FOOD Take midmorning OTHER DEA Schedule IV Do not cut, chew, or crush tablet

Drug	Dosage form	Dosing	Generic/Price	Food / Other
Phendimetrazine immediate-release Bontril® PDM	Tablet 35 mg	Weight loss Dosing: 35 mg two to three times a day Max: 210 mg/day (2 tablets 3 times a day) See precautions for dosing in kidney and liver disease	YES/$	FOOD Take one hour before meals OTHER DEA Schedule III In some cases, half a tablet (17.5 mg) per dose may be adequate Tablets are scored so they may be cut in two

Drug	Dosage form	Dosing	Generic/Price	Food / Other
Phendimetrazine extended-release Bontril®	Capsule, extended-release 105 mg	Weight loss Dosing: 105 mg once daily Max: 105 mg once daily See precautions for dosing in kidney and liver disease	YES/$	FOOD Take 30 - 60 minutes before morning meal OTHER DEA Schedule III

Drug	Dosage form	Dosing	Generic/Price	Food / Other
Phentermine immediate-release Adipex-P®	Tablet 37.5 mg Capsule 15 mg 30 mg 37.5 mg	Weight loss Dosing: 37.5 mg once daily Max: 37.5 mg once daily Tablet can be split and given twice a day See precautions for dosing in kidney and liver disease	YES/$	FOOD May take before breakfast or 1-2 hours after breakfast OTHER DEA Schedule IV For some patients, half tablet (18.75 mg) daily may be adequate In some cases, it may be desirable to give half tablets (18.75 mg) two times a day Tablets are scored so that they may be cut in two

Drug	Dosage form	Dosing	Generic/Price	Food / Other
Phentermine immediate-release Lomaira™	Tablet 8 mg Table is scored so it may be halved	Weight loss Dosing: 1 tablet three times a day 30 minutes before meals Max: 8 mg three times a day Tablet may be halved for 4 mg dose See precautions for dosing in kidney and liver disease	NO/$	FOOD Take 30 minutes before meals OTHER DEA Schedule IV Tablets are scored so that they may be halved

Drug	Dosage form	Dosing	Generic/Price	Food / Other
Phentermine orally-disintegrating tablet Suprenza™	Tablet, orally-disintegrating 15 mg 30 mg 37.5 mg	Weight loss Dosing: 15 - 37.5 mg once daily Max: 37.5 mg once daily See precautions for dosing in kidney and liver disease	NO/$$$$	FOOD May be taken without regard to food OTHER DEA Schedule IV Place tablet on tongue where it will dissolve, then swallow with or without water

• COMBINATION PRODUCT WITH TOPIRAMATE

Drug	Dosage form	Dosing	Generic/Price	Food/Other
Qsymia® Phentermine + Topiramate	Capsule phentermine/topiramate 3.75/23 mg 7.5/46 mg 11.25/69 mg 15/92 mg	Weight loss Starting: 3.75/23 mg once daily for 14 days Maintenance: 7.5/46 mg once daily Max: 15/92 mg once daily Evaluate weight loss after 12 weeks on 7.5/46 mg dose. If patient has not lost ≥ 3% of baseline body weight, discontinue or increase to next highest dose by giving 11.25/69 mg for 14 days, then 15/92 mg once daily. If patients has not lost ≥ 5% of baseline body weight after 12 weeks on 15/92 mg dose, then discontinue When discontinuing 15/92 mg dose, take every other day for 1 week to avoid precipitating seizure 3.75/23 mg and 11.25/69 mg doses are for titration purposes only	NO/$$$$	FOOD May be taken without regard to food. Take in morning. OTHER DEA Schedule IV Topiramate is a seizure medication. See topiramate for more Providers and pharmacies must register in the Qsymia REMS program in order to prescribe