BMJ guidelines contradict another professional organization on spinal injections for chronic back pain

The issue: Spinal injections and procedures for chronic back pain are common; evidence supporting their effectiveness is weak.

Primary care relevance: Provides recommendations on spinal injections and procedures for chronic back pain based on evidence from clinical trials.

FDA-approved suzetrigine selectively inhibits NaV1.8 sodium channels in peripheral sensory neurons

The issue: Chronic pain often requires multiple options; novel mechanisms may help patients with inadequate response or tolerability.

Primary care relevance: New drug class now available to treat pain

Menaquinone-7 significantly reduced frequency of nocturnal leg cramps in adults 65+

The issue: Nocturnal leg cramps are common in older adults; effective, low-risk treatments are limited.

Why this study matters: Evaluates the effects of vitamin K2 (menaquinone-7) on nocturnal leg cramps in adults aged 65 and older.

Primary care relevance: Vitamin K2 may be a low-risk option to try for nocturnal leg cramps; larger trials would strengthen the evidence.

New study compares hip replacement surgery to physical therapy for severe hip osteoarthritis

The issue: Patients with severe hip osteoarthritis face a choice between surgery and non-surgical management; comparative evidence is valuable.

Why this study matters: Compares hip replacement surgery to physical therapy for the treatment of severe hip osteoarthritis.

Primary care relevance: Provides evidence on the benefits of hip replacement surgery vs physical therapy for severe hip osteoarthritis.