ANTIBIOTIC CHART









Cefadroxil (Duricef®)

Dosage form
Capsule
  • 500 mg ($)
Tablet
  • 1000 mg ($)
Suspension
  • 250 mg/5 ml ($-$$)
  • 500 mg/5 ml ($-$$)

Dosing
Pediatric
  • Impetigo - 30 mg/kg/day (max 1000 mg/day) given once daily or divided into 2 doses (PI)
  • Skin infections - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses (PI)
  • Strep throat - 30 mg/kg once daily (max 1000 mg/day) for 10 days (IDSA)
  • Urinary tract infection - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses (PI)
Adults
  • Skin infections - 1000 mg/day given once daily or divided into 2 doses (PI)
  • Strep throat - 1000 mg/day given once daily or divided into 2 doses for 10 days (IDSA)
  • Urinary tract infection - 1000 - 2000 mg/day given once daily or divided into 2 doses for 3 - 7 days (IDSA, PI)

Other
  • Cefadroxil is a first generation cephalosporin
  • May take without regard to food
  • Kidney disease (adults)
    • CrCl < 50 ml/min: dose adjustment recommended; see cefadroxil PI

Cephalexin (Keflex®)

Dosage form
Capsule
  • 250 mg ($)
  • 500 mg ($)
  • 750 mg ($$$-$$$$)
Tablet
  • 250 mg ($-$$)
  • 500 mg ($-$$)
Suspension
  • 125 mg/5 ml ($)
  • 250 mg/5 ml ($)

Dosing
Pediatric
  • Cellulitis (non-MRSA) - 25 - 50 mg/kg/day (max 2000 mg/day) given in 4 divided doses for 5 - 10 days (IDSA)
  • Endocarditis prophylaxis - 50 mg/kg (max 2000 mg) 30 - 60 minutes before procedure (penicillin allergic without severe reaction) (AHA)
  • Impetigo - 25 – 50 mg/kg/day (max 1000 mg/day) given in 3 – 4 divided doses for 7 days (IDSA)
  • Otitis media - 75 - 100 mg/kg/day given in 4 divided doses for 5 - 10 days (PI)
  • Strep throat - 40 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 10 days (IDSA)
  • Urinary tract infection - 50 - 100 mg/kg/day (max 2000 mg/day) given in 4 divided doses for 7 - 14 days (CTE)
Adults (15 years and older)

Other
  • Cephalexin is a first generation cephalosporin
  • May take without regard to food
  • Cephalexin is a first generation cephalosporin
  • Cephalexin may increase metformin levels
  • Kidney disease - clearance is reduced. Manufacturer makes no specific recommendation.

Cefaclor (Ceclor®)

Dosage form
Capsule
  • 250 mg ($)
  • 500 mg ($)
Suspension
  • 125 mg/5 ml ($)
  • 250 mg/5 ml ($$$)
  • 375 mg/5 ml ($$-$$$)

Dosing
Pediatric
Adults

Other
  • Cefaclor is a second generation cephalosporin
  • Food slows absorption but does not affect the extent of absorption
  • Liver disease - manufacturer makes no dosage recommendation
  • Kidney disease - no dose adjustment necessary

Cefprozil (Cefzil®)

Dosage form
Tablet
  • 250 mg ($)
  • 500 mg ($)
Suspension
  • 125 mg/5 ml ($)
  • 250 mg/5 ml ($)

Dosing
Pediatric (6 months - 12 years)
  • Cellulitis - 20 mg/kg/day (max 1000 mg/day) given once daily for 10 days (PI)
  • Otitis media - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 10 days (PI)
  • Pneumonia, community-acquired - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 7 - 10 days (IDSA)
  • Sinusitis - 15 - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 10 days (PI)
  • Strep throat - 15 mg/kg/day (max 500 mg/day) given in 2 divided doses for 10 days (PI)
Adolescents and Adults (age 12 years and older)
  • Cellulitis - 250 - 500 mg twice a day or 500 mg once daily for 10 days (PI)
  • Sinusitis - 250 - 500 mg twice a day for 10 days (PI)
  • Strep throat - 500 mg once daily for 10 days (PI)

Other
  • Cefprozil is a second generation cephalosporin
  • May take without regard to food
  • Liver disease - no dose adjustment necessary
  • Kidney disease
    • CrCl ≤ 29 ml/min: - use half the standard dose

Cefuroxime (Ceftin®)

Dosage form
Tablet
  • 125 mg (?)
  • 250 mg ($)
  • 500 mg ($)
Suspension
  • 125 mg/5 ml ($$$$)
  • 250 mg/5 ml ($$$$)

Dosing
Pediatric (3 months to 12 years)
  • NOTE: Pediatric dosing is for suspension only. Suspension and tablet are not bioequivalent on a mg-to-mg basis.
  • Impetigo - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 10 days (PI)
  • Otitis media - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 5 - 10 days (AAP)
  • Pneumonia, community-acquired - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 7 - 10 days (IDSA)
  • Sinusitis - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses for a minimum of 10 days (AAP)
  • Strep throat - 20 mg/kg/day (max 500 mg/day) given in 2 divided doses for 10 days (PI)
  • Urinary tract infection - 20 - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 7 - 14 days (CTE)
Adolescents and Adults (13 years and older)

Other
  • Cefuroxime is a second generation cephalosporin
  • Suspension should be taken with food
  • Tablets may be taken without regard to food
  • Tablets and suspension are not substitutable on a mg-to-mg basis
  • Kidney disease
    • CrCl ≥ 30 ml/min - no adjustment necessary
    • CrCl 10 - 29 ml/min - give standard individual dose every 24 hours
    • CrCl < 10 ml/min - give standard individual dose every 48 hours

Cefdinir (Omnicef®)

Dosage form
Capsule
  • 300 mg ($)
Suspension
  • 125 mg/5 ml ($)
  • 250 mg/5 ml ($)

Dosing
Pediatric (6 months - 12 years)
  • Otitis media - 14 mg/kg/day (max 600 mg/day) given in 1 or 2 divided doses for 5 - 10 days (AAP)
  • Sinusitis - 14 mg/kg/day (max 600 mg/day) given in 1 or 2 divided doses for a minimum of 10 days (AAP)
  • Skin infections - 7 mg/kg/dose (max 300 mg/dose) twice a day for 10 days (PI)
  • Strep throat - 7 mg/kg/dose (max 300 mg/dose) twice a day for 5 to 10 days OR 14 mg/kg (max 600 mg/day) once daily for 10 days (PI)
Adults and Adolescents (Age 13 years and older)

Other
  • Cefdinir is a third generation cephalosporin
  • May take without regard to food
  • Iron supplements and antacids reduce cefdinir absorption. Do not take within 2 hours of each other.
  • Cefdinir and iron may cause stool to turn red
  • Liver disease - no dose adjustment necessary
  • Kidney disease
    • CrCl < 30 ml/min: adult dose is 300 mg once daily; pediatric dose is 7 mg/kg/day (max 300 mg/day) given once daily

Cefditoren (Spectracef®)

Dosage form
Tablet
  • 200 mg ($$$$)
  • 400 mg ($$$$)
  • Discontinued in U.S.

Dosing
Adults and Adolescents (Age 12 years and older)

Other
  • Cefditoren has been discontinued in the U.S.
  • Cefditoren is a third generation cephalosporin
  • Take with a meal to increase absorption
  • Drugs that reduce gastric acidity (e.g. antacids, H2 blockers, PPIs) decrease absorption
  • Liver disease
    • Child-Pugh A/B: no dose adjustment necessary
    • Child-Pugh C: has not been studied
  • Kidney disease
    • CrCl > 50 ml/min: No dose adjustment necessary
    • CrCl 30 - 49 ml/min: 200 mg twice a day
    • CrCl < 30 ml/min: 200 mg once daily

Cefixime (Suprax®)

Dosage form
Capsule
  • 400 mg ($ for 1 capsule)
Tablet, chewable
  • 100 mg ($ for 2 tablets)
  • 200 mg ($$ for 2 tablets)
Suspension
  • 100 mg/5 ml ($$ for 50 ml)
  • 200 mg/5 ml ($$$ for 50 ml)
  • 500 mg/5 ml (?)

Dosing
Pediatric (6 months - 12 years)
Adults and Adolescents (Age 12 years and older)

Other
  • Cefixime is a third generation cephalosporin
  • May take without regard to food
  • Kidney disease
    • CrCl ≥ 60 ml/min: no dose adjustment necessary
    • CrCl < 60 ml/min: dose adjustment recommended; see Suprax PI [sec 2.3] for recommendations

Cefpodoxime (Vantin®)

Dosage form
Tablet
  • 100 mg ($)
  • 200 mg ($$)
Suspension
  • 50 mg/5 ml ($)
  • 100 mg/5 ml ($$)

Dosing
Pediatric (age 2 months through 12 years)
  • Otitis media - 10 mg/kg/day (max 400 mg/day) given in 2 divided doses for 5 - 10 days (AAP)
  • Pneumonia, community-acquired - 10 mg/kg/day (max 400 mg/day) given in 2 divided doses for 7 - 10 days (IDSA)
  • Sinusitis - 10 mg/kg/day (max 400 mg/day) given in 2 divided doses for a minimum of 10 days (AAP)
  • Strep throat - 10 mg/kg/day (max 200 mg/day) given in 2 divided doses for 5 - 10 days (PI)
  • Urinary tract infection - 10 mg/kg/day (max 400 mg/day) given in 2 divided doses for 7 - 14 days (CTE)
Adolescents and Adults (age 12 years and older)

Other
  • Cefpodoxime is a third generation cephalosporin
  • Suspension may be taken without regard to food
  • Tablets should be taken with food
  • Drugs that reduce gastric acidity (e.g. antacids, H2 blockers, PPIs) decrease absorption
  • Liver disease - no dose adjustment necessary
  • Kidney disease
    • CrCl < 30 ml/min: increase dosing interval to every 24 hours

Ceftibuten (Cedax®)

Dosage form
Capsule
  • 400 mg ($$$$)
Suspension
  • 180 mg/5 ml ($$$$)

Dosing
Pediatric
  • Otitis media - 9 mg/kg/day (max 400 mg/day) given once daily for 10 days (PI)
  • Strep throat - 9 mg/kg/day (max 400 mg/day) given once daily for 10 days (PI)
Adolescents and Adults (age 12 years and older)

Other
  • Ceftibuten is a third generation cephalosporin
  • Ceftibuten should be taken at least 2 hours before or one hour after a meal. Food decreases absorption.
  • Liver disease - manufacturer makes no dosage recommendation
  • Kidney disease
    • CrCl > 50 ml/min: No dose adjustment necessary
    • CrCl 30 - 49 ml/min: 4.5 mg/kg/day or 200 mg once daily
    • CrCl 5 - 29 ml/min: 2.25 mg/kg/day or 100 mg once daily

Ceftriaxone (Rocephin®)

Dosage form
Vial
  • 250 mg ($)
  • 500 mg ($)
  • 1000 mg ($)
  • 2000 mg ($)

Dosing
Pediatric
Adult

Other
  • Ceftriaxone is a third generation cephalosporin
  • Do not give to neonates ≤ 28 days old with hyperbilirubinemia
  • Liver disease - no dose adjustment necessary
  • Kidney disease - no dose adjustment necessary
  • Kidney and liver disease (concurrent) - do not exceed 2 grams daily



First generation
  • Cefadroxil (Duricef®)
  • Cephalexin (Keflex®)
  • Cefazolin (Ancef®)
Second generation
  • Cefaclor (Ceclor®)
  • Cefoxitin (Mefoxin®)
  • Cefotetan (Cefotan®)
  • Cefprozil (Cefzil®)
  • Cefuroxime (Ceftin®)
Third generation
  • Cefdinir (Omnicef®)
  • Cefditoren (Spectracef®)
  • Cefixime (Suprax®)
  • Cefotaxime (Claforan®)
  • Cefpodoxime (Vantin®)
  • Ceftazidime (Fortaz®)
  • Ceftibuten (Cedax®)
  • Ceftriaxone (Rocephin®)
Fourth generation
  • Cefepime (Maxipime®)



Clindamycin (Cleocin®)

Dosage form
Capsule
  • 75 mg ($$$$)
  • 150 mg ($)
  • 300 mg ($)
Solution
  • 75 mg/5 ml ($$)
Vaginal cream
  • 2%, 40 gm tube ($-$$)
Vaginal suppository
  • 100 mg ($$$$)
Topical

Dosing
Pediatric
  • Cellulitis (MRSA coverage) - 30 - 40 mg/kg/day (max 1800 mg/day) given in 3 divided doses for 5 - 10 days (IDSA)
  • Endocarditis prophylaxis - 20 mg/kg (max 600 mg) 30 - 60 minutes before procedure (penicillin allergic) (AHA)
  • Impetigo - 20 mg/kg/day (max 1600 mg/day) given in 3 divided doses for 7 days (IDSA)
  • Otitis media - 30 – 40 mg/kg/day (max 1800 mg/day) given in 3 divided doses for 5 - 10 days (AAP)
  • Sinusitis - 8 - 12 mg/kg/day divided into 3 or 4 equal doses for a minimum of 10 days. Give with Cefixime (Suprax®). See AAP sinusitis recs. (AAP, PI)
  • Strep throat - 7 mg/kg/dose (max 300 mg/dose) three times daily for 10 days (IDSA)
Adults

Other
  • May take without regard to food
  • Liver disease - dose adjustment not likely necessary
  • Kidney disease - no dose adjustment necessary



Fosfomycin (Monurol®)

Dosage form
Powder
  • 3 gram packet ($$)

Dosing
Adults

Other
  • May take without regard to food
  • Mix packet with 3 - 4 ounces of water
  • Kidney disease - clearance is decreased. Manufacturer makes no specific recommendation.



Azithromycin (Zithromax®)

Dosage form
Tablet
  • 250 mg ($)
  • 500 mg ($)
  • 600 mg ($)
Suspension
  • 100 mg/5 ml ($)
  • 200 mg/5 ml ($)
Powder, one packet
  • 1000 mg ($)
Suspension, extended-release (Zmax®)
  • 2 grams/bottle ($$$)
Ophthalmic

Dosing
Pediatric (0 - 5 months)
  • Bordetella pertussis (treatment or postexposure prophylaxis)
    • < 1 month - 10 mg/kg/day given once daily for 5 days (CDC)
    • 1 - 5 months - 10 mg/kg/day given once daily for 5 days (CDC)
Pediatric (6 months to 12 years)
  • Bordetella pertussis (treatment or postexposure prophylaxis) - 10 mg/kg given as a single dose on day 1, then 5 mg/kg/day (max 500 mg) given once daily on days 2 - 5 (CDC)
  • Campylobacter - 10 mg/kg/day (max 500 mg/day) given once daily for 3 - 5 days (CTE)
  • Cat scratch disease
    • < 45 kg - 10 mg/kg (max 500 mg) on Day 1 followed by 5 mg/kg/day (max 250 mg/day) on Days 2 - 5
    • > 45 kg - 500 mg on Day 1 followed by 250 mg once daily on Days 2 - 5 (IDSA)
  • E. coli, enterotoxigenic - 10 mg/kg/day (max 500 mg/day) given once daily for 3 days (CTE)
  • Endocarditis prophylaxis -15 mg/kg (max 500 mg) 30 - 60 minutes before procedure (penicillin allergic) (AHA)
  • Pneumonia, community-acquired, atypical - 10 mg/kg (max 500 mg) on Day 1 followed by 5 mg/kg/day (max 250 mg/day) given once daily on Days 2 - 5 (IDSA)
  • Salmonella (nontyphoidal) - 20 mg/kg/day (max 500 mg/day) given once daily for 7 days (CTE)
  • Shigella - 10 mg/kg/day (max 500 mg/day) given once daily for 3 days (CTE)
  • Strep throat - 12 mg/kg/day (max 500 mg/day) given once daily for 5 days (IDSA)
  • Vibrio vulnificus - 10 mg/kg/day (max 500 mg/day) given once daily for 3 days (CTE)
Adolescents and Adults

Other
  • May take without regard to food
  • Do not take with aluminum or magnesium antacids
  • Kidney disease
    • CrCl > 10 ml/min: no dose adjustment necessary
    • CrCl < 10 ml/min: use caution

Studies

Clarithromycin (Biaxin®)

Dosage form
Tablet
  • 250 mg ($)
  • 500 mg ($)
Suspension
  • 125 mg/5 ml ($)
  • 250 mg/5 ml ($$)
Tablet, extended-release (Biaxin XL®)
  • 500 mg ($-$$)

Dosing
Pediatric (0 - 5 months)
  • Bordetella pertussis (treatment or postexposure prophylaxis)
    • < 1 month - Not recommended. Use azithromycin. (CDC)
    • 1 - 5 months - 15 mg/kg/day given in 2 divided doses for 7 days (CDC)
Pediatric (≥ 6 months and children)
  • Bordetella pertussis (treatment or postexposure prophylaxis) - 15 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 7 days (CDC)
  • Endocarditis prophylaxis - 15 mg/kg (max 500 mg) 30 - 60 minutes before procedure (penicillin allergic) (AHA)
  • H. pylori - Clarithromycin - 20 mg/kg/day (max 1000 mg/day) given in 2 divided doses +
  • H. pylori, sequential therapy - see H. pylori treatment
  • Pneumonia, community-acquired, atypical - 15 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 7 - 10 days (IDSA)
  • Strep throat - 15 mg/kg/day (max 500 mg/day) given in 2 divided doses for 10 days (IDSA)
Adults

Other
  • Standard-release tablet and suspension may be taken without regard to food. Extended-release tablets should be taken with food.
  • Clarithromycin is a Strong CYP3A4 inhibitor
  • Clarithromycin is not recommended in patients with heart disease because of a potential increased risk of heart problems or death that can occur years later
  • Clarithromycin is not recommended in pregnancy
  • Liver disease - no dose adjustment necessary
  • Kidney disease
    • CrCl < 30 ml/min: - reduce dose by 50%

Studies

Erythromycin | Eryc® | ERY-tab® | E.E.S.® | Eryped® | PCE® | Pediamycin®

Erythromycin base
Capsule, enteric coated (Eryc®)
  • 250 mg ($$$)
Tablet, enteric coated (Ery-tab®)
  • 250 mg ($$$$)
  • 333 mg ($$$$)
  • 500 mg ($$$$)
Tablet, enteric coated (PCE®)
  • 333 mg ($$$$)
  • 500 mg ($$$$)
Tablet
  • 250 mg ($$-$$$)
  • 500 mg ($$-$$$)
Ophthalmic
Topical

Erythromycin ethylsuccinate
Tablet (E.E.S.®)
  • 400 mg ($$$$)
Granule (E.E.S.®, Eryped®)
  • 200 mg/5 ml ($$$$)
  • 400 mg/5 ml ($$$$)
Suspension (E.E.S.®, Pediamycin®)
  • 200 mg/5 ml ($$$$)
  • 400 mg/5 ml ($$$$)

Erythromycin stearate
Tablet
  • 250 mg (?)

Dosing
Pediatric (0 - 5 months)
  • Bordetella pertussis (treatment or postexposure prophylaxis)
    • < 1 month: 40 - 50 mg/kg/day given in 4 divided doses for 14 days. Dosing is for erythromycin base. Azithromycin is the preferred agent in this age group. (CDC)
    • 1 - 5 months: 40 - 50 mg/kg/day given in 4 divided doses for 14 days. Dosing is for erythromycin base. (CDC)
Pediatric (≥ 6 months and children)
  • Bordetella pertussis (treatment or postexposure prophylaxis)
    • Erythromycin base: 40 - 50 mg/kg/day (max 2000 mg/day) given in 4 divided doses for 14 days (CDC)
  • Campylobacter
    • Erythromycin base - 30 mg/kg/day given in 2 - 4 divided doses for 3 - 5 days (CTE)
  • Impetigo
    • Erythromycin ethylsuccinate - 40 mg/kg/day (max 1600 mg/day) given in 3 – 4 divided doses for 7 days (IDSA)
  • Pneumonia, community-acquired, atypical
    • Erythromycin ethylsuccinate - 40 mg/kg/day (max 1600 mg/day) given in 4 divided doses for 7 - 10 days (IDSA)
Adolescents and adults
  • Acne
    • Erythromycin base: 250 - 500 mg once daily or 250 - 500mg twice a day (AAP)
  • Bordetella pertussis (treatment or postexposure prophylaxis)
    • Erythromycin base - 500 mg four times a day for 14 days (CDC)
  • Campylobacter
    • Erythromycin base - 500 mg two to four times a day for 3 - 5 days (IDSA/CTE)
  • Chlamydia
    • Erythromycin base - 500 mg four times a day for 7 days (CDC)
    • Erythromycin ethylsuccinate - 800 mg four times a day for 7 days (CDC)
  • Impetigo
    • Erythromycin base - 250 mg four times a day for 7 days (IDSA)
    • Erythromycin ethylsuccinate - 400 mg four times a day for 7 days (IDSA)
  • Pneumonia, community-acquired
    • Erythromycin base - 500 mg four times a day or 1000 mg twice a day for 7 - 14 days (IDSA, CTE) [2]
    • Erythromycin ethylsuccinate - 800 mg four times a day or 1600 mg twice a day for 7 - 14 days

Other
  • May take without regard to food
  • 400 mg of erythromycin ethylsuccinate is equivalent to 250 mg of erythromycin base or stearate
  • Erythromycin is a Moderate CYP3A4 inhibitor
  • Erythromycin is contraindicated with lovastatin and simvastatin
  • Liver disease - use caution. Manufacturer makes no specific recommendation.
  • Kidney disease - erythromycin is mostly excreted in the bile. Manufacturer makes no specific recommendation.

Studies

Fidaxomicin (Dificid®)

Dosage form
Tablet
  • 200 mg ($$$$)

Dosing
Adults

Other
  • May take without regard to food
  • Fidaxomicin undergoes minimal absorption and should not be used for systemic infections
  • Liver disease - fidaxomicin undergoes minimal absorption. Liver disease should not affect.
  • Kidney disease - no dose adjustment necessary



Nitrofurantoin | Macrobid® | Macrodantin® | Furadantin®

Dosage form
Macrobid® capsule
    Nitrofurantoin monohydrate : Nitrofurantoin macrocrystalline
    • 75 mg : 25 mg ($)
Macrodantin® capsule
    Nitrofurantoin macrocrystalline
    • 25 mg ($$)
    • 50 mg ($)
    • 100 mg ($)
Furadantin® suspension
    Nitrofurantoin
    • 25 mg/5 ml ($$$$)

Dosing
Pediatric (one month and older)
Adults
  • Urinary tract infection
    • Macrobid® - 100 mg twice a day for 5 days (IDSA)
    • Macrodantin® - 50 - 100 mg 4 times a day for 7 days (PI)
  • Urinary tract infection, prophylaxis
    • Postcoital - 50 - 100 mg one time postcoital (Macrobid® or Macrodantin®) (CTE)
    • Continuous - 50 - 100 mg once daily (Macrobid® or Macrodantin®) (CTE)

Other
  • Take with food
  • Do not take with antacids containing magnesium
  • Nitrofurantoin has been associated with rare cases of interstitial lung disease in patients who took it for ≥ 6 months
  • Kidney disease
    • CrCl < 60 ml/min: - do not use



Metronidazole | Flagyl® | Nuvessa®

Dosage form
Tablet
  • 250 mg ($)
  • 500 mg ($)
Tablet, extended-release (Flagyl® ER)
  • 750 mg ($$$$)
Capsule
  • 375 mg ($$)
Vaginal gel (Metrogel-vaginal®)
  • 0.75% gel
  • Comes in 70 g tube ($$)
Vaginal gel (Nuvessa®)
  • 1.3% gel
  • Comes in single-dose applicator ($$$$)
Topical (rosacea)

Dosing
Pediatric
Adults

Other
  • May take standard-release without regard to food. Extended-release should be taken one hour before or 2 hours after meals.
  • Potential for disulfiram-like reaction if taken with alcohol. Do not ingest alcohol during, or for 3 days after stopping metronidazole.
  • Liver disease
    • Mild to moderate (Child-Pugh A/B): no dose adjustment necessary
    • Severe (Child-Pugh C): reduce dose by 50%
  • Kidney disease - patients with end-stage renal disease may have decreased clearance. Manufacturer makes no specific recommendation.

Secnidazole (Solosec®)

Dosage form
Oral granules
  • 2 grams ($$$$)

Dosing
Adults

Other
  • May take without regard to food
  • Granules are sprinkled on applesauce, yogurt, or pudding. Mixture should be consumed within 30 minutes without chewing.
  • Granules do not dissolve and are not meant to be dissolved in liquid
  • Does not appear to interact with alcohol
  • Liver disease - manufacturer makes no specific recommendation
  • Kidney disease - manufacturer makes no specific recommendation

Tinidazole (Tindamax®)

Dosage form
Tablet
  • 250 mg ($)
  • 500 mg ($)

Dosing
Pediatric (3 years and older)
  • Entamoeba histolytica - 50 mg/kg/day (max 2000 mg/day) given once daily for 3 days (PI)
  • Giardia - 50 mg/kg (max 2000 mg) given as a one time dose (PI)
Adults

Other
  • Take with food to minimize stomach upset
  • Tinidazole is a CYP3A4 sensitive substrate
  • Potential for disulfiram-like reaction if taken with alcohol. Do not ingest alcohol during, or for 3 days after stopping tinidazole.
  • Liver disease - use caution. Manufacturer makes no specific recommendation.
  • Kidney disease - no dose adjustment necessary



Linezolid (Zyvox®)

Dosage form
Tablet
  • 600 mg ($$)
Suspension
  • 100 mg/5 ml ($$$$)

Dosing
Pediatric
  • Cellulitis (MRSA coverage)
    • < 5 years old - 10 mg/kg/dose every 8 hours for 5 - 10 days (IDSA, PI)
    • 5 - 11 years old - 10 mg/kg/dose (max 600 mg/dose) twice a day for 5 - 10 days (IDSA, PI)
  • Pneumonia, community-acquired
    • < 12 years old - 30 mg/kg/day given in 3 divided doses for 7 - 10 days (IDSA)
    • ≥ 12 years old - 20 mg/kg/day (max 1200 mg/day) given in 2 divided doses for 7 - 10 days (IDSA)
Adults (12 years and older)

Other
  • May take without regard to food
  • Linezolid is a reversible, nonselective MAO inhibitor
  • Do not take within 2 weeks of other MAO inhibitors
  • May increase pressor effect of adrenergic agents including pseudoephedrine and phenylpropanolamine. Foods containing tyramine should also be avoided in large quantities (e.g. aged cheeses, fermented or air-dried meats, sauerkraut, soy sauce, tap beers, and red wines)
  • Has been associated with serotonin syndrome. Use caution when taken with antidepressants and other serotonergic drugs.
  • Liver disease
    • Mild to moderate (Child-Pugh A/B): no dose adjustment necessary
    • Severe (Child-Pugh C): has not been evaluated
  • Kidney disease - no dose adjustment necessary

Studies



Amoxicillin (Amoxil®)

Dosage form
Capsule
  • 250 mg ($)
  • 500 mg ($)
Tablet
  • 500 mg ($)
  • 875 mg ($)
Tablet, chewable
  • 125 mg ($)
  • 250 mg ($)
Tablet, extended-release (Moxatag®)
  • 775 mg ($$$)
Suspension
  • 125 mg/5 ml ($)
  • 200 mg/5 ml ($)
  • 250 mg/5 ml ($)
  • 400 mg/5 ml ($)

Dosing
Pediatric
  • Endocarditis prophylaxis - 50 mg/kg (max 2000 mg) 30 - 60 minutes before procedure (AHA)
  • H. pylori - Amoxicillin - 50 mg/kg/day (max 2000 mg/day) given in 2 divided doses +
  • H. pylori, sequential therapy - see H. pylori treatment
  • Otitis media - 80 - 90 mg/kg/day given in 2 divided doses for 5 - 10 days (AAP)
  • Pneumonia, community-acquired - 90 mg/kg/day (max 4000 mg/day) given in 2 divided doses for 7 - 10 days (IDSA)
  • Sinusitis
    • Standard therapy - 45 mg/kg/day given in 2 divided doses for a minimum of 10 days (AAP)
    • High-dose therapy - 80 to 90 mg/kg/day (max 4000 mg/day) given in 2 divided doses for a minimum of 10 days (AAP)
  • Strep throat - 50 mg/kg/day (max 1000 mg/day) given once daily or in 2 divided doses for 10 days (IDSA)
Adults

Other
  • May take without regard to food
  • Kidney disease
    • CrCl 10 - 30 ml/min: 250 - 500 mg every 12 hours
    • CrCl < 10 ml/min: 250 - 500 mg every 24 hours

Amoxicillin - Clavulanate potassium (Augmentin®)

Dosage form
Tablet (amoxil : clav)
  • 250 mg : 125 mg ($-$$)
  • 500 mg : 125 mg ($)
  • 875 mg : 125 mg ($)
Tablet, chewable (amoxil : clav)
  • 7:1 ratio
    • 200 mg : 28.5 mg ($)
    • 400 mg : 57 mg ($-$$)
Tablet, extended-release (Augmentin XR®)
  • 1000 mg : 62.5 mg ($$-$$$$)
Suspension (amoxil:clav)
  • 4:1 ratio
    • 125 mg : 31.25 mg/5 ml ($$$$)
    • 250 mg : 62.5 mg/5 ml ($)
  • 7:1 ratio
    • 200 mg : 28.5 mg/5 ml ($)
    • 400 mg : 57 mg/5 ml ($)
  • 14:1 ratio (Augmentin ES®)
    • 600 mg : 42.9 mg/5 ml ($)

Dosing
Pediatric
  • Impetigo - 25 mg/kg/day (max 1750 mg/day) of the amoxicillin component given in 2 divided doses for 7 days (IDSA)
  • Otitis media - 90 mg/kg/day of amoxicillin, with 6.4 mg/kg/day of clavulanate [amoxicillin to clavulanate ratio, 14:1] (max 4000 mg/day) in 2 divided doses for 5 - 10 days (AAP)
  • Pneumonia, community-acquired - 90 mg/kg/day (max 4000 mg/day) given in 2 divided doses for 7 - 10 days (IDSA)
  • Sinusitis - 80 – 90 mg/kg/day of the amoxicillin component with 6.4 mg/kg/day of clavulanate [amoxicillin to clavulanate ratio, 14:1] in 2 divided doses (max 4000 mg/day) for a minimum of 10 days (AAP)
  • Urinary tract infection - 20 - 40 mg/kg/day given in 3 divided doses for 7 - 14 days (CTE)
Adults

Other
  • May take without regard to meals, although taking with food may help reduce gastrointestinal upset
  • Amoxicillin-clavulanate preparations with a 14:1 ratio of amoxicillin-clavulanate may be less likely to cause diarrhea than preparations with a lower ratio
  • Kidney disease
    • Standard tablet and suspension
      • CrCl < 30 ml/min: do not give 875 mg dose
      • CrCl 10 - 30 ml/min: 250 - 500 mg every 12 hours
      • CrCl < 10 ml/min: 250 - 500 mg every 24 hours

Dicloxacillin

Dosage form
Capsule
  • 250 mg
  • 500 mg ($)

Dosing
Pediatric
  • Cellulitis (non-MRSA) - 25 - 50 mg/kg/day (max 2000 mg/day) given in 4 divided doses for 5 - 10 days (IDSA)
Adults

Other
  • Should be taken on an empty stomach at least 1 hour before and 2 hours after a meal
  • Kidney disease - dose reduction recommended. Manufacturer makes no specific recommendation.

Penicillin G benzathine (Bicillin L-A®)

Dosage form
Disposable syringe
  • 1 ml - 600,000 units ($$)
  • 2 ml - 1,200,000 units ($$$$)
  • 4 ml - 2,400,000 units ($$$$)

Dosing
Pediatric
  • Strep throat
    • < 27 kg - 600,000 units IM single dose (IDSA)
    • ≥ 27 kg - 1,200,000 units IM single dose (IDSA)
  • Impetigo
    • ≤ 6 kg - 225 mg (300,000 units) IM given as a one time dose
    • 6.1 - 10 kg - 337.5 mg (450,000 units) IM given as a one time dose
    • 10.1 - 15 kg - 450 mg (600,000 units) IM given as a one time dose
    • 15.1 - 20 kg - 675 mg (900,000 units) IM given as a one time dose
    • > 20 kg - 900 mg (1,200,000 units) IM given as a one time dose
Adults
  • Strep throat - 1,200,000 units IM single dose
  • Syphilis
    • Primary and secondary - 2.4 million units IM single dose (CDC)
    • Early latent - 2.4 million units IM single dose (CDC)
    • Latent - 2.4 million units IM once a week for a total of 3 doses (CDC)
    • Tertiary - 2.4 million units IM once a week for a total of 3 doses (CDC)

Other
  • For intramuscular use only
  • Kidney disease - clearance is decreased. Manufacturer makes no specific recommendation.
  • Milligram-unit conversion
    • 225 mg = 300,000 units
    • 337.5 mg = 450,000 units
    • 450 mg = 600,000 units
    • 675 mg = 900,000 units
    • 900 mg = 1,200,000 units

Penicillin (Pen VK®)

Dosage form
Tablet
  • 250 mg ($)
  • 500 mg ($)
Solution
  • 125 mg/5 ml ($)
  • 250 mg/5 ml ($)

Dosing
Pediatric
  • Strep throat - 250 mg two to three times a day for 10 days (IDSA)

Adults

Other
  • May take without regard to meals
  • Kidney disease - drug clearance is decreased. Manufacturer makes no specific dosage recommendation.



Ciprofloxacin (Cipro®)

Dosage form
Tablet
  • 100 mg (?)
  • 250 mg ($)
  • 500 mg ($)
  • 750 mg ($)
Tablet, extended-release (Cipro XR®)
  • 500 mg ($-$$)
  • 1000 mg ($-$$)
Suspension
  • 250 mg/5 ml ($-$$)
  • 500 mg/5 ml ($-$$)
Ophthalmic
Otic

Dosing
Pediatric (≥ 1 year old)
Adults

Other
  • May take without regard to food
  • Do not take with tizanidine (Zanaflex®)
  • Take 2 hours before or 6 hours after magnesium or aluminum antacids
  • Ciprofloxacin is a Strong CYP1A2 inhibitor
  • May cause photosensitivity. Limit sun exposure, use sunscreen.
  • Liver disease - in studies involving patients with chronic cirrhosis, no significant changes in ciprofloxacin pharmacokinetics were observed. The effects of acute hepatic insufficiency on ciprofloxacin are unknown.
  • Kidney disease
    • Standard-release
      • CrCl > 50 ml/min: no dose adjustment necessary
      • CrCl 30 - 50 ml/min: 250 - 500 mg every 12 hours
      • CrCl 5 - 29 ml/min: 250 - 500 mg every 18 hours
    • Extended-release
      • CrCl ≤ 30 ml/min: - 500 mg once daily

Delafloxacin (Baxdela™)

Dosage form
Tablet
  • 450 mg ($$$$)

Dosing
Adults

Other
  • May take without regard to food
  • Take 2 hours before or 6 hours after chelating agents (e.g. magnesium or aluminum antacids, sucralfate, multivitamins, iron)
  • Liver disease - no dosage adjustment necessary
  • Kidney disease
    • CrCl ≥ 30 ml/min: no dose adjustment necessary
    • CrCl 15 - 29 ml/min: no dose adjustment necessary
    • CrCl < 15 ml/min: not recommended

Gemifloxacin (Factive®)

Dosage form
Tablet
  • 320 mg ($$$$)

Dosing
Adults

Other
  • May take without regard to food
  • Antacids, sucralfate, metal cations (e.g. iron), and multivitamins may reduce gemifloxacin absorption. Gemifloxacin should be taken 3 hours before or 2 hours after these medications.
  • Liver disease - no dose adjustment necessary
  • Kidney disease
    • CrCl ≤ 40 ml/min: 160 mg every 24 hours

Levofloxacin (Levaquin®)

Dosage form
Tablet
  • 250 mg ($)
  • 500 mg ($)
  • 750 mg ($)
Solution
  • 25 mg/ml ($$)
Ophthalmic

Dosing
Pediatric
  • Pneumonia, community-acquired
    • 6 months - 5 years old - 16 - 20 mg/kg/day given in 2 divided doses for 7 - 10 days (IDSA)
    • 5 - 16 years old - 8 - 10 mg/kg/day (max 750 mg/day) given once daily for 7 - 10 days (IDSA)
  • Sinusitis - 16 mg/kg/day (max 500 mg/day) given in 2 divided doses for a minimum of 10 days (AAP)
Adults
  • aDue to methicillin-susceptible Staphylococcus aureus, Streptococcus pneumoniae (including multidrug-resistant isolates [MDRSP]), Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Chlamydophila pneumoniae, Legionella pneumophila, or Mycoplasma pneumoniae
  • bDue to Streptococcus pneumoniae (excluding multi-drug-resistant isolates [MDRSP]), Haemophilus influenzae, Haemophilus parainfluenzae, Mycoplasma pneumoniae, or Chlamydophila pneumoniae
  • c due to Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis and pyelonephritis due to E. coli, including cases with concurrent bacteremia
  • d Enterococcus faecalis, Enterococcus cloacae, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa; and for pyelonephritis due to E. coli

Other
  • May take without regard to food
  • Antacids, sucralfate, metal cations (e.g. iron), and multivitamins may reduce levofloxacin absorption. Do not take within 2 hours of each other.
  • Quinolones have not been considered first-line agents in children because of the possible risk of adverse effects on developing cartilage. In studies, these effects appear to be uncommon. [1]
  • May cause photosensitivity. Limit sun exposure, use sunscreen.
  • Liver disease - no dose adjustment necessary
  • Kidney disease
    • CrCl ≤ 49 ml/min: dose adjustment recommended; see Levaquin® PI for more.

Moxifloxacin (Avelox®)

Dosage form
Tablet
  • 400 mg ($)
Ophthalmic

Dosing
Adults

Other
  • May take without regard to food
  • Antacids, sucralfate, metal cations (e.g. iron), and multivitamins may reduce moxifloxacin absorption. Moxifloxacin should be taken 4 hours before or 8 hours after these medications.
  • Liver disease - no dose adjustment necessary
  • Kidney disease - no dose adjustment necessary

Ofloxacin

Dosage form
Tablet
  • 200 mg
  • 300 mg
  • 400 mg ($$)
Ophthalmic
Otic

Dosing
Adults

Other
  • May take without regard to food
  • Antacids, sucralfate, metal cations (e.g. iron), and multivitamins may reduce ofloxacin absorption. Do not take within 2 hours of each other.
  • May cause photosensitivity. Limit sun exposure, use sunscreen.
  • Liver disease
    • Severe (Child-Pugh C): do not exceed 400 mg/day
  • Kidney disease
    • CrCl 20 - 50 ml/min: usual dose every 24 hours
    • CrCl < 20 ml/min: half the usual dose every 24 hours



Rifaximin (Xifaxan®)

Dosage form
Tablet
  • 200 mg ($$$$)
  • 550 mg ($$$$)

Dosing
Adults and children ≥ 12 years old
Adults (≥ 18 years old)
  • Hepatic encephalopathy - 550 mg two times a day (PI)
  • Irritable bowel syndrome (IBS) with diarrhea - 550 mg three times a day for 14 days. Patients with recurrence may be retreated up to two times with the same regimen. (PI)

Other
  • May take without regard to food
  • Rifaximin is not effective against diarrhea complicated by fever and/or blood in stool or diarrhea due to pathogens other than E. Coli
  • Rifaximin undergoes minimal systemic absorption and its effects are thought to be local
  • Rifaximin is a P-glycoprotein substrate. P-glycoprotein inhibitors may increase systemic exposure. The clinical significance of increased rifaximin exposure is unknown.
  • Liver disease
    • Mild to moderate (Child-Pugh A/B): Exposure is increased. No dose adjustment recommended.
    • Severe (Child-Pugh C): Exposure is increased. No dose adjustment recommended. Use caution.
  • Kidney disease - has not been studied



Sulfamethoxazole - Trimethoprim | Septra® | Bactrim®

Dosage form
Tablet (Sulfa/TMP)
  • 800/160 mg (double strength) ($)
  • 400/80 mg (single strength) ($)
Suspension (Sulfa/TMP)
  • 200 mg/40 mg/5 ml ($)

Dosing
Pediatric (≥ 2 months old)
  • NOTE: All pediatric dosing based on trimethoprim component
  • Bordetella pertussis (treatment or postexposure prophylaxis) - 8 mg/kg/day given in 2 divided doses for 14 days (CDC)
  • Cellulitis (MRSA coverage): 8 – 12 mg/kg/day given in 2 divided doses for 5 - 10 days (IDSA)
  • Cyclospora - 5 mg/kg/day (max 320 mg/day) given in 2 divided doses for 3 days (CTE)
  • Impetigo
    • Once daily - 8 mg/kg/day (max 320 mg/day) given once daily for 5 days
    • Twice daily - 8 mg/kg/day (max 320 mg/day) given in two divided doses for 3 days
  • Salmonella, nontyphoidal - 10 mg/kg/day (max 320 mg/day) given in 2 divided doses for 5 - 7 days (IDSA)
  • Shigella - 10 mg/kg/day (max 320 mg/day) given in 2 divided doses for 3 days (IDSA)
  • Urinary tract infection - 6 - 12 mg/kg/day (max 320 mg/day) given in 2 divided doses for 7 - 14 days (CTE)
  • Urinary tract infection, prophylaxis - 3 mg/kg/day (max 40 mg/day) given once daily (CTE)
Adolescents and adults

Other
  • May be taken without regard to food
  • May cause photosensitivity. Limit sun exposure, use sunscreen.
  • Trimethoprim may raise potassium levels in susceptible patients
  • Trimethoprim is a CYP2C8 inhibitor
  • Trimethoprim is an OCT2 inhibitor and substrate
  • Sulfamethoxazole is a Weak CYP2C9 inhibitor
  • Liver disease - do not use in patients with significant liver disease
  • Kidney disease
    • CrCL > 30 ml/min: no dose adjustment necessary
    • CrCl 15 - 30 ml/min: use half the usual dose
    • CrCl < 15 ml/min: do not use



Doxycycline | Acticlate® | Vibramycin® | Doryx® | Oracea®

Doxycycline monohydrate
Tablet
  • 50 mg ($)
  • 75 mg ($)
  • 100 mg ($)
  • 150 mg ($$)
Capsule
  • 50 mg ($)
  • 75 mg ($$-$$$)
  • 100 mg ($)
  • 150 mg ($$$-$$$$)
Capsule (Oracea®)
  • 40 mg ($$$$)
  • Contains 30 mg immediate release and 10 mg delayed release
Suspension
  • 25 mg/5 ml ($)
  • Comes in 60 ml bottle

Doxycycline hyclate
Capsule
  • 50 mg ($)
  • 100 mg ($)
Capsule, delayed release
  • 75 mg (?)
  • 100 mg (?)
Tablet
  • 20 mg ($)
  • 50 mg ($$$$)
  • 75 mg ($$$$)
  • 100 mg ($)
  • 150 mg ($$$$)
Tablet (Acticlate®)
  • 75 mg ($$$$)
  • 150 mg ($$$$)
Tablet, delayed release (Doryx®)
  • 50 mg ($$)
  • 75 mg ($$)
  • 100 mg ($$)
  • 150 mg ($$$)
  • 200 mg ($$$$)
Tablet, delayed release (Doryx® MPC)
  • 60 mg ($$$$)
  • 120 mg ($$$$)
  • Doryx® MPC 120 mg is equivalent to 100 mg of standard doxycycline, and 60 mg = 50 mg

Dosing
Pediatric (≥ 8 years old)
Adolescents and adults

Other
  • May be taken without regard to food (except Oracea®)
  • Take with full glass of water to reduce risk of esophageal irritation
  • Dairy products do not affect doxycycline absorption
  • Tetracyclines are contraindicated in pregnancy
  • Concomitant use of tetracyclines and isotretinoin has been associated with pseudotumor cerebri. Concurrent use should be avoided.
  • May cause photosensitivity. Limit sun exposure, use sunscreen.
  • Antacids may decrease bioavailability of doxycycline. Do not take within 4 hours of each other.
  • Doxycycline should not be used in children < 8 years old because of possible tooth discoloration
  • Kidney disease - no dose adjustment necessary

Minocycline | Minocin® | Dynacin® | Solodyn® | Ximino™

Dosage form
Capsule
  • 50 mg ($)
  • 75 mg ($)
  • 100 mg ($)
Tablet
  • 50 mg ($$)
  • 75 mg ($$-$$$)
  • 100 mg ($$$)
Tablet, extended-release (Solodyn®)
  • 45 mg ($$$$)
  • 65 mg ($$$$)
  • 90 mg ($$$$)
  • 115 mg ($$$$)
  • 135 mg ($$$$)
Capsule, extended-release (Ximino™)
  • 45 mg ($$$$)
  • 90 mg ($$$$)
  • 135 mg ($$$$)

Dosing
Adolescents and adults - standard-release
Adolescents and adults - extended-release tablets (Solodyn®)
  • Acne ∼ 1 mg/kg/day (max 135 mg/day) given once daily (PI)
Adolescents and adults - extended-release capsules (Ximino™)
  • Acne ∼ 1 mg/kg/day (max 135 mg/day) given once daily (PI)

Other
  • May be taken without regard to food
  • Dairy products do not affect minocycline absorption
  • Take with full glass of water to reduce risk of esophageal irritation
  • Tetracyclines are contraindicated in pregnancy
  • Antacids may decrease bioavailability of minocycline. Do not take within 4 hours of each other.
  • May cause photosensitivity. Limit sun exposure, use sunscreen.
  • Concomitant use of tetracyclines and isotretinoin has been associated with pseudotumor cerebri. Concurrent use should be avoided.
  • May cause hyperpigmentation around scars, shins, and mucous membranes with prolonged use
  • Minocycline should not be used in children < 8 years old because of possible tooth discoloration
  • Liver disease - use caution. Manufacturer makes no specific recommendation.
  • Kidney disease - has not been studied. Manufacturer makes no specific recommendation.

Sarecycline (Seysara™)

Dosage form
Tablet
  • 60 mg ($$$$)
  • 100 mg ($$$$)
  • 150 mg ($$$$)

Dosing
Children ≥ 9 years old and adults
  • Acne
    • 33 - 54 kg: 60 mg once daily
    • 55 - 84 kg: 100 mg once daily
    • 85 - 136 kg: 150 mg once daily (PI)

Other
  • May take without regard to food
  • Take with full glass of water to reduce risk of esophageal irritation
  • Tetracyclines are contraindicated in pregnancy
  • May cause photosensitivity. Limit sun exposure, use sunscreen.
  • Antacids may decrease bioavailability of sarecycline. Do not take within 4 hours of each other.
  • Concomitant use of tetracyclines and isotretinoin has been associated with pseudotumor cerebri. Concurrent use should be avoided.
  • Sarecycline is a P-glycoprotein inhibitor
  • Liver disease
    • Child-Pugh A/B: no dose adjustment necessary
    • Child-Pugh C: has not been studied
  • Kidney disease - manufacturer states that "renal impairment" has no clinically significant effect on pharmacokinetics, but it has not been studied in end-stage renal disease

Tetracycline (Achromycin V®)

Dosage form
Capsule
  • 250 mg ($$$)
  • 500 mg ($$$$)

Dosing
Adolescents and adults

Other
  • Take at least 1 hour before food or two hours after
  • Dairy products taken at the same time as tetracycline may decrease absorption
  • Take with full glass of water to reduce risk of esophageal irritation
  • Tetracyclines are contraindicated in pregnancy
  • Antacids may decrease bioavailability of tetracycline. Do not take within 4 hours of each other.
  • May cause photosensitivity. Limit sun exposure, use sunscreen.
  • Concomitant use of tetracyclines and isotretinoin has been associated with pseudotumor cerebri. Concurrent use should be avoided.
  • Tetracycline should not be used in children < 8 years old because of possible tooth discoloration
  • Liver disease - manufacturer makes no specific recommendation
  • Kidney disease - dose reduction recommended. Manufacturer makes no specific recommendation.



Pricing legend
  • $ = 0 - $50
  • $$ = $51 - $100
  • $$$ = $101 - $150
  • $$$$ = > $151
  • ? = Pricing not found. Availability may be limited.
  • Pricing based on one month of therapy at standard dosing in an adult
  • Pricing based on information from GoodRX.com®
  • Pricing may vary by region and availability