Zoliflodacin and gepotidacin offer oral alternatives to injectable ceftriaxone

The issue: Gonorrhea resistance to current therapies is increasing.

Primary care relevance: Providers now have two new oral antibiotics to treat gonorrhea, potentially improving treatment access and patient convenience.

Retreatment reduces viral loads and symptoms by one day but shows no meaningful benefit on hospitalizations or deaths

The issue: Some patients experience COVID symptom rebound after completing Paxlovid; the safety and benefit of retreatment have not been studied.

Why this study matters: This study evaluated the safety and benefits of a second course of Paxlovid in patients with rebound COVID symptoms.

Primary care relevance: Provides guidance on whether to retreat COVID-19 patients experiencing rebound symptoms.

Combined oral and topical therapy in male partners significantly reduces BV recurrence in females

The issue: Bacterial vaginosis recurrence is common; the role of partner treatment has been debated.

Why this study matters: Randomized controlled trial evaluating the effects of treating male partners of women with recurrent bacterial vaginosis.

Primary care relevance: Provides evidence on the benefits of treating male partners of women with recurrent bacterial vaginosis.

New antibiotic for uncomplicated female UTIs; also shows efficacy against gonorrhea

The issue: Resistance and limited oral options complicate treatment of uncomplicated UTIs and gonorrhea.

Primary care relevance: Providers have a new oral antibiotic for female UTIs; it may also be useful for gonorrhea in appropriate settings.

Sulopenem plus probenecid (Orlynvah) approved for uncomplicated UTIs in women

The issue: Multidrug-resistant uropathogens and limited oral options make UTI treatment challenging.

Primary care relevance: A new oral option for UTIs; consider cost and resistance patterns when selecting therapy.

Review of pneumococcal vaccines including efficacy in clinical trials

The issue: Pneumococcal vaccination is widely recommended, but the evidence supporting its effectiveness is limited.

Primary care relevance: Review of pneumococcal vaccines and their efficacy in clinical trials.